Piperidines
Biotium Involucrin(IVRN/827), CF647 conjugate, 0.1mg/mL
This antibody recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like
Biotium Testosterone(4E1G2), CF568 conjugate, 0.1mg/mL
This MAb is highly specific to testosterone. Its affinity constant for testosterone is ~1010 M-1. In competitive binding immunoassay, it reacts with testosterone 100%, 11-beta-hydroxy testosterone 3.3%, 17-alpha-methyl testosterone <0.1%, 5-alpha DHT 0.8%, estradiol <0.1% and progesterone <0.1%. Testosterone, a steroid hormone from the androgen group, is derived from cholesterol. Testosterone is primarily secreted in the testes, but the ovaries and adrenal glands also produce smaller amounts. It is the principal male sex hormone and is responsible for the maturation of sex organs and the development of male secondary sex characteristics. The hormone is also involved in the growth of muscle mass and increases bone density and maturation. It functions by activating the androgen receptor and converting to estradiol and activation of estrogen receptors. Testosterone has been employed therapeutically to treat many conditions including infertility, lack of libido, osteopor
Medchemexpress LLC Apixaban-¹³C,d₃ | 1261393-15-0 | 99.5% | C2413CH22D3N5O4 | 5 MG
Apixaban-13C,d3 is a deuterium and 13C labeled Apixaban, a highly selective, reversible inhibitor of Factor Xa. It is suitable for use as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. This product is for research use only and not sold to patients. Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules as tracers for quantitation during drug development, and deuteration may affect pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes for quantitation in drug development
- Deuteration may affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC HY-B0750 5mg Medchemexpress, Dolasetron CAS:115956-12-2 Purity:>98%
Medchemexpress, HY-B0750 5mg Dolasetron CAS:115956-12-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Biotium Thyroglobulin(6E1.), CF568 conjugate, 0.1mg/mL
Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a
Biotium Thyroglobulin(6E1.), CF594 conjugate, 0.1mg/mL
Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a
Medchemexpress LLC Lenalidomide-propargyl-C2-NH2 (hydrochloride) | 2489242-23-9 | 98.0% | 50 MG
Lenalidomide-propargyl-C2-NH2 hydrochloride is a compound that incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. It can be used to design PROTAC MD-224 (HY-114312). This compound is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase.
- Contains a linker.
- Can be used to design PROTACs.
- Functions as a click chemistry reagent.
- Contains an alkyne group for reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups.
Medchemexpress LLC Pomalidomide 4'-alkylC5-acid | 2225940-49-6 | 98.8% | 50 MG
Pomalidomide 4'-alkylC5-acid is an E3 ligase ligand-linker conjugate. It contains a Pomalidomide-based cereblon (CRBN) ligand and a linker. This product can be utilized in the synthesis of PROTAC.
- Serves as an E3 ligase ligand-linker conjugate for the synthesis of PROTACs.
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC Pomalidomide-C12-NH2 hydrochloride | 2862774-02-3 | 97.1% | C25H37ClN4O4 | 10MG
Pomalidomide-C12-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that serves as the Cereblon-binding component in PROTAC constructs targeting KRAS G12C. Supplied as the hydrochloride salt, it is provided as a solid for use in targeted protein degradation research and biochemical assay development.
- E3 ligase ligand-linker conjugate suitable for Cereblon-based PROTAC design.
- Hydrochloride salt form; solid, light yellow to green yellow appearance.
- High purity (97.1%).
- Molecular formula C25H37ClN4O4; molecular weight 493.04 g·mol⁻1.
- Recommended storage at -20°C; protect from light.
- Available in small research sizes (5-500 mg).
Medchemexpress LLC HY-114406 5mg Medchemexpress, TD-106 CAS:2250288-69-6 Purity:>98%
Medchemexpress, HY-114406 5mg TD-106 CAS:2250288-69-6 TD-106 is a cereblon ( CRBN ) modulator, which can be used for targeted protein degradation. BRD4 PROTAC s with TD-106 induce BRD4 degradation [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Lenalidomide-propargyl-C2-NH2 hydrochloride | 2489242-23-9 | 98.01% | 100 MG
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. It is also a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Incorporates cereblon (CRBN) ligand
- E3 ubiquitin ligase ligand
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Can be used to design PROTAC MD-224
Revvity Health Sciences Inc HTRF Human and Mouse Total Cereblon Detection Kit, 50,000 Assay Points
HTRF Human and Mouse Total Cereblon Detection Kit, 50,000 Assay Points
Medchemexpress LLC Lenalidomide-propargyl-C2-NH2 hydrochloride | 2489242-23-9 | 98.0% | C18H20ClN3O3 | 10MG
Lenalidomide-propargyl-C2-NH2 hydrochloride is a lenalidomide-derived cereblon (CRBN) ligand provided as the hydrochloride salt and intended as a building block for targeted protein degradation research and click-chemistry conjugation in PROTAC development.
- Lenalidomide-derived CRBN ligand for E3 ligase recruitment.
- Contains a propargyl (alkyne) handle for click chemistry conjugation.
- Supplied as the hydrochloride salt for improved handling and stability.
- High purity (98.0%).
- Chemical formula C18H20ClN3O3; molecular weight 361.82.
- Suitable for chemical biology and PROTAC design applications.