Piperidines
Medchemexpress LLC GDC-0276 10mg | 1494581-70-2 | 10 MG
GDC-0276 is a small-molecule NaV1.7 (voltage-gated sodium channel 1.7) inhibitor supplied as a solid white to off-white powder for research use only. It is provided with supporting documentation including a datasheet, COA, and SDS.
- High purity 99.69%
- Molecular formula C24H31FN2O4S
- Molecular weight 462.58
- Physical form solid, white to off-white
- Supplied as a 10 mg vial
- For research use only; not for human or diagnostic use
Apexbio Technology LLC SB 747651A dihydrochloride 10mg
SB 747651A dihydrochloride is a small-molecule inhibitor targeting mitogen- and stress-activated protein kinase 1 (MSK1) It is designed to selectively inhibit MSK1 activity thereby interfering with phosphorylation-mediated signal transduction pathways downstream of MSK1 SB 747651A dihydrochloride exerts its biological activity primarily through competitive inhibition of MSK1 kinase disrupting phosphorylation of the transcription factor CREB and histone H3 Based on these pharmacological properties SB 747651A dihydrochloride holds research potential in inflammation pathways stress-responsive gene regulation cellular proliferation and differentiation and neuronal plasticity
![eMolecules 71989-35-0 | (2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]butanoic acid | Synthonix - Stock397.471 | C23H27NO5 | 95.000 | C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 100g | 507877972](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000170304.jpg-250.jpg)
eMolecules 71989-35-0 | (2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]butanoic acid | Synthonix - Stock397.471 | C23H27NO5 | 95.000 | C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 100g | 507877972
(2S,3R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]butanoic acid | Synthonix - Stock | 71989-35-0397.471 | C23H27NO5 | 95.000 | C[C@@H](OC(C)(C)C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 100g | 507877972
Apexbio Technology LLC GYKI 47261 dihydrochloride 220445-20-5 50mg
GYKI 47261 dihydrochloride is a non-competitive antagonist of AMPA receptors a class of ionotropic glutamate receptors mediating excitatory neurotransmission By blocking AMPA-induced currents in a concentration-dependent manner it regulates glutamatergic signaling In research it has been used to evaluate neuroprotection in ischemic models study motor dysfunction and dyskinesias from dopaminergic therapy assess tremor suppression and probe AMPA receptor roles in neurological disorders Additionally it modulates CYP2E1 enzyme activity in human and rodent hepatocytes These properties support its application in studies of neuroprotection movement disorders tremor regulation neurological pathology and metabolism
eMolecules 913548-29-5 | Medchem Express | AR-9281 | 5mg | 475641492 | HY-111151 | 319.449 | C18H29N3O2
Medchem Express | AR-9281 | 5mg | 475641492 | HY-111151 | 913548-29-5 | 319.449 | C18H29N3O2
Selleck Chemical LLC Crenolanib S2730-50mg
Crenolanib is a potent and selective inhibitor of PDGFR / with Kd of 2 1 nM/3 2 nM in CHO cells also potently inhibits FLT3 sensitive to D842V mutation not V561D mutation 100-fold more selective for PDGFR than c-Kit VEGFR-2 TIE-2 FGFR-2 EGFR erbB2 and Src Crenolanib helps to induce mitophagy
Chem-Impex International, Inc. 4-Amino-1-methylpiperidine | 41838-46-4 | MFCD01570549 | 5G
4-Amino-1-methylpiperidine, 41838-46-4, MFCD01570549, 5G
![eMolecules 406216-02-2 | (R)-3-Aminopiperidin-2-one hydrochloride | Ambeed | MFCD09752974 | 150.610 | C5H11ClN2O | 95.000 | Cl.N[C@@H]1CCCNC1=O | 1g | 525037357](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000159618.jpg-250.jpg)
eMolecules 406216-02-2 | (R)-3-Aminopiperidin-2-one hydrochloride | Ambeed | MFCD09752974 | 150.610 | C5H11ClN2O | 95.000 | Cl.N[C@@H]1CCCNC1=O | 1g | 525037357
(R)-3-Aminopiperidin-2-one hydrochloride | Ambeed | 406216-02-2 | MFCD09752974 | 150.610 | C5H11ClN2O | 95.000 | Cl.N[C@@H]1CCCNC1=O | 1g | 525037357
Apexbio Technology LLC LDN 209929 dihydrochloride 50mg
LDN 209929 dihydrochloride is a small-molecule inhibitor targeting haspin kinase a serine/threonine kinase It is designed to inhibit haspin kinase activity thereby regulating chromosomal alignment and mitotic progression LDN 209929 dihydrochloride exerts its biological activity primarily through selective inhibition of haspin kinase It demonstrates an IC50 of approximately 55 nM and exhibits around 180-fold selectivity over DYRK2 kinase Based on these pharmacological properties LDN 209929 dihydrochloride holds research potential in oncology studies related to aberrant mitotic control and tumor cell proliferation
![eMolecules 550999-75-2 | ENCENICLINE | AstaTech | MFCD23381267 | 320.840 | C16H17ClN2OS | 95.000 | Clc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2 | 0.1g | 721956328](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502468529.JPG-250.jpg)
eMolecules 550999-75-2 | ENCENICLINE | AstaTech | MFCD23381267 | 320.840 | C16H17ClN2OS | 95.000 | Clc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2 | 0.1g | 721956328
ENCENICLINE | AstaTech | 550999-75-2 | MFCD23381267 | 320.840 | C16H17ClN2OS | 95.000 | Clc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2 | 0.1g | 721956328
Apexbio Technology LLC CHIR-124 405168-58-3 5mg
CHIR-124 (CAS 405168-58-3) is a selective small-molecule inhibitor of checkpoint kinase 1 (Chk1) with an IC50 of 0 3 nM demonstrating over 2 000-fold selectivity versus Chk2 (IC50 0 7 M) It also inhibits PDGFR and FLT3 with nanomolar potency CHIR-124 abrogates DNA damage-induced S and G2-M cell cycle checkpoints and enhances mitotic cell death particularly in p53-deficient tumor cells In preclinical studies CHIR-124 potentiates the cytotoxicity of topoisomerase I poisons such as camptothecin and irinotecan and increases radiosensitivity in various p53-mutant human tumor models This compound is widely used to investigate DNA damage response mechanisms and potential combination strategies in cancer therapy research