Pyrazines
TARGETMOL CHEMICALS INC RSV604 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RSV604 ((S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-23-dihydro-1H-benzo[e][14]diazepin-3-yl)urea) is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 uM)purity: 98%
TARGETMOL CHEMICALS INC ORM-10103 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ORM-10103 is a novel potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nM at -80 and 20 mV respectively and reduced early and delayed postdepolarization in canine hearts. purity: 98%
TARGETMOL CHEMICALS INC NAVTEMADLIN 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Navtemadlin (AMG232) is a potent selective and orally available inhibitor of p53-MDM2 interaction (IC50 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM. purity: 98%
TARGETMOL CHEMICALS INC EHOP-016 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 uM for Rac1 in MDA-MB-231 and MDA-MB-435 cells equally effective inhibition for Rac3. purity: 99%
TARGETMOL CHEMICALS INC PLANTAGOSIDE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Plantagoside is a specific non-competitive inhibitor for jack bean alpha-mannosidase (IC50 5 uM). It also is a potent inhibitor of the Maillard reaction. purity: 99%
TARGETMOL CHEMICALS INC G36 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. G36 is a cell-permeable non-steroidal antagonist of GPER. G36 inhibits activation by either 17(beta)-estradiol or the GPER-selective agonist G-1 (IC50 = 112 and 165 nM respectively). G36 has no detectable binding activity to either ER(alpha) or ER(beta). G36 blocks the activation of PI3K or calcium mobilization triggered by estrogen through GPER and it suppresses ERK activation by estrogen or G-1 but not by EGF. G-36 can be used in combination with GPER-selective agonists like G-1 to distinguish the roles of GPER from those of ER(alpha) and ER(beta) in complex biological systems. purity: 99%
TARGETMOL CHEMICALS INC LIPOFERMATA 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Lipofermata is a fatty acid transport protein (FATP) inhibitor that prevents lipid transport to melanoma cells and reduces melanoma growth and invasion. purity: 99%
TARGETMOL CHEMICALS INC EN523 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1. purity: 98%
Chemscene ChemScene | (5-Methoxypyrazin-2-yl)methanol | 1G | CS-0043604 | 0.98 | 72788-88-6| MFCD22398583 | 140.14
ChemScene | (5-Methoxypyrazin-2-yl)methanol | 1G | CS-0043604 | 0.98 | 72788-88-6| MFCD22398583 | 140.14
TARGETMOL CHEMICALS INC MMRI62 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MMRi62 (7-[(23-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53 also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12. purity: 99%