Pyrazines
Medchemexpress LLC Br-C3-methyl ester | 4897-84-1 | 181.03 | 100 G
Br-C3-methyl ester is an Alkyl/ether-based PROTAC linker used in the synthesis of PROTAC PD-1/PD-L1 degrader-1. It functions by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether-based PROTAC linker
- Purity: 99.1%
- Molecular weight: 181.03
- Formula: C5H9BrO2
- Appearance: Liquid
- Color: Colorless to light yellow
Medchemexpress LLC Methyl methanesulfonate (Standard) | 66-27-3 | 110.13 | 100 G
Methyl methanesulfonate is an alkylating agent that transfers methyl groups and induces DNA damage. It is a biochemical reagent used as a biological material or organic compound for life science-related research. This product is for research use only and not sold to patients.
- Transfers methyl groups
- Induces DNA damage
- Used as a biochemical reagent
- Suitable for life science-related research
TARGETMOL CHEMICALS INC JAK-IN-11 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK has the potential for the skin disorders treatment. purity: 99%
Medchemexpress LLC Methyl vanillate | 3943-74-6 | 99.88% | C9H10O4 | 100 G
Methyl vanillate, found in Oryza sativa Linn., acts as a Wnt/β-catenin pathway activator. This benzoate ester, a methyl ester of vanillic acid, also functions as an antioxidant and a plant metabolite.
- Acts as a Wnt/β-catenin pathway activator
- Functions as an antioxidant
- Functions as a plant metabolite
- Increases expression and nuclear translocation of β-catenin in calvarial osteoblasts
- Elevates ALP activity in calvarial osteoblasts
- Solid form storage: 4°C under nitrogen
- Solution storage: -80°C for 6 months or -20°C for 1 month under nitrogen
Medchemexpress LLC Pyrazine | 290-37-9 | 99.97% | 80.09 | 500 G
Pyrazine is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, known for its electron-deficient property. It serves as a key pharmacophore in various drugs and acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic, and anti-inflammatory activities.
- Undergoes Chichibabin reaction with sodamide to form 2-aminopyrazine.
- Reacts with 30% H2O2/CH3COOH at 70-80 °C to form mono and dioxide products.
- Can be synthesized via catalytic dehydrogenation of ethanolamine or via double condensation of a 1,2-dicarbonyl compound with equimolar 1,2-diamine followed by oxidation.
- It is a monobasic compound with a pKa of 0.65, protonated at N-1, and only undergoes N,N-diprotonation in very strong acidic media.
Medchemexpress LLC 5-Hydroxypyrazine-2-Carboxylic Acid | 34604-60-9 | 99.99% | C5H4N2O3 | 5 G
5-Hydroxypyrazine-2-Carboxylic Acid is a metabolite of the anti-tuberculosis drug pyrazinamide (PZA). It is intended for research use only and has a high purity of 99.99%.
- Metabolite of anti-tuberculosis drug pyrazinamide (PZA)
- For research use only
- High purity of 99.99%
- Solid appearance
- Molecular weight: 140.10
- Molecular formula: C5H4N2O3
- CAS number: 34604-60-9
- Off-white to light brown in color
- Consistent 1H NMR spectrum
- Soluble in DMSO and water
Medchemexpress LLC 5,6-Diamino-1,10-phenanthroline | 168646-54-6 | 210.23 | 500 MG
5,6-Diamino-1,10-phenanthroline can be used as ligands for metal ions for drug synthesis. It is intended for research use only, and not sold to patients.
- Used as ligands for metal ions for drug synthesis
- Appearance: solid
- Color: yellow to orange
- Solid storage: 4°C, protected from light, stored under nitrogen
- Solvent storage: -80°C for 6 months, or -20°C for 1 month (protected from light, stored under nitrogen)
Apexbio Technology LLC SCR7 pyrazine 14892-97-8 5mg
SCR7 pyrazine (CAS 14892-97-8) is a small-molecule inhibitor of DNA ligase IV a critical enzyme in the nonhomologous end-joining (NHEJ) pathway responsible for repairing DNA double-strand breaks (DSBs) By disrupting the DNA binding activity of ligase IV SCR7 impedes the NHEJ-mediated repair process leading to reduced cell viability and increased apoptosis In cellular assays SCR7 demonstrated dose-dependent inhibition of proliferation in various cancer cell lines with reported IC50 values ranging from 8 5 to 120 M Additionally in mouse models SCR7 administration suppressed tumor growth and enhanced sensitivity to DSB-inducing therapies highlighting its utility for studying DNA repair mechanisms and potential as an adjunct in cancer research
eMolecules 2417-73-4 | Methyl 2-bromomethylbenzoate | Ambeed | MFCD03425900 | 229.073 | C9H9BrO2 | 95.000 | COC(=O)c1ccccc1CBr | 100g | 490552203
Methyl 2-bromomethylbenzoate | Ambeed | 2417-73-4 | MFCD03425900 | 229.073 | C9H9BrO2 | 95.000 | COC(=O)c1ccccc1CBr | 100g | 490552203