Pyridines and derivatives
3-Bromo-5-phenylpyridine 98.0+%, TCI America™
CAS: 142137-17-5 Molecular Formula: C11H8BrN Molecular Weight (g/mol): 234.096 MDL Number: MFCD04114223 InChI Key: AWCQJXPOCRXHNK-UHFFFAOYSA-N PubChem CID: 2762904 IUPAC Name: 3-bromo-5-phenylpyridine SMILES: C1=CC=C(C=C1)C2=CC(=CN=C2)Br
2,3-Dibromo-5-chloropyridine 98.0+%, TCI America™
CAS: 137628-17-2 Molecular Formula: C5H2Br2ClN Molecular Weight (g/mol): 271.34 MDL Number: MFCD08687254 InChI Key: GDUFWKJMOOVEMX-UHFFFAOYSA-N Synonym: 2,3 dibromo-5-chloro pyridine,5-chloro-2,3-dibromopyridine,2,3-dibromo-5-chloro-pyridine,pyridine, 2,3-dibromo-5-chloro,pubchem5397,acmc-209cej,ksc494o0p,2,3-dibromo-5-chloro pyridine,2,3-dibromo-5-dichloropyridine,abbypharma ap-30-4531 PubChem CID: 11000162 IUPAC Name: 2,3-dibromo-5-chloropyridine SMILES: ClC1=CC(Br)=C(Br)N=C1
2-Bromo-3-methylpyridine 97.0+%, TCI America™
CAS: 3430-17-9 Molecular Formula: C6H6BrN Molecular Weight (g/mol): 172.03 MDL Number: MFCD00239380 InChI Key: PZSISEFPCYMBDL-UHFFFAOYSA-N Synonym: 2-bromo-3-picoline,2-bromo-3-methylpyridin,2-bromo-3-methyl pyridine,2-bromo-3-methyl-pyridine,3-methyl-2-bromopyridine,pyridine, 2-bromo-3-methyl,2-brom-3-methylpyridin,pubchem9208,2-bromo-3-mehtylpyridine PubChem CID: 220832 IUPAC Name: 2-bromo-3-methylpyridine SMILES: CC1=CC=CN=C1Br
3-Bromo-2-chloro-5-nitropyridine 98.0+%, TCI America™
CAS: 5470-17-7 Molecular Formula: C5H2BrClN2O2 Molecular Weight (g/mol): 237.437 MDL Number: MFCD00233989 InChI Key: PTTQIUHVDDBART-UHFFFAOYSA-N PubChem CID: 230889 IUPAC Name: 3-bromo-2-chloro-5-nitropyridine SMILES: C1=C(C=NC(=C1Br)Cl)[N+](=O)[O-]
3,6-Dichloro-2-pyridinecarboxylic Acid 98.0+%, TCI America™
CAS: 1702-17-6 Molecular Formula: C6H3Cl2NO2 Molecular Weight (g/mol): 192.00 MDL Number: MFCD00078655 InChI Key: HUBANNPOLNYSAD-UHFFFAOYSA-N Synonym: clopyralid,3,6-dichloropicolinic acid,3,6-dichloro-2-pyridinecarboxylic acid,lontrel,2-pyridinecarboxylic acid, 3,6-dichloro,clopyralide,benzalox,cirtoxin,matrigon,transline PubChem CID: 15553 ChEBI: CHEBI:62961 IUPAC Name: 3,6-dichloropyridine-2-carboxylic acid SMILES: OC(=O)C1=NC(Cl)=CC=C1Cl
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98.0+%, TCI America™
CAS: 72537-17-8 Molecular Formula: C6H2ClF4N Molecular Weight (g/mol): 199.53 MDL Number: MFCD00191918 InChI Key: GDSROTVTTLUHCO-UHFFFAOYSA-N Synonym: 3-chloro-2-fluoro-5-trifluoromethyl pyridine,2-fluoro-3-chloro-5-trifluoromethyl pyridine,2-fluoro-3-chloro-5-trifluoromethylpyridine,pyridine, 3-chloro-2-fluoro-5-trifluoromethyl,acmc-20aied,librarion l939,3-chloro-2-fluoro-5 trifluoromethyl pyridine,3-chloro-2-fluoro-5-trifluoromethyl-pyridine PubChem CID: 1268075 IUPAC Name: 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine SMILES: FC1=C(Cl)C=C(C=N1)C(F)(F)F
1-(3-Sulfopropyl)pyridinium Hydroxide Inner Salt 98.0+%, TCI America™
CAS: 15471-17-7 Molecular Formula: C8H11NO3S Molecular Weight (g/mol): 201.24 MDL Number: MFCD00064468 InChI Key: REEBJQTUIJTGAL-UHFFFAOYSA-N Synonym: 3-pyridin-1-ium-1-yl propane-1-sulfonate,ndsb-201,1-3-sulphonatopropyl pyridinium,unii-qn4i6ai9ek,3-1-pyridinio-1-propanesulfonate,1-pyridiniumpropane-3-sulfonate,qn4i6ai9ek,1-3-sulfopropyl pyridinium hydroxide, inner salt,pyridinium, 1-3-sulfopropyl-, inner salt,1-3-sulfonatopropyl pyridin-1-ium PubChem CID: 84929 IUPAC Name: 1-(3-sulfonatopropyl)pyridin-1-ium SMILES: [O-]S(=O)(=O)CCC[N+]1=CC=CC=C1
1-(3-Sulfopropyl)pyridinium Hydroxide Inner Salt 98.0+%, TCI America™
CAS: 15471-17-7 Molecular Formula: C8H11NO3S Molecular Weight (g/mol): 201.24 MDL Number: MFCD00064468 InChI Key: REEBJQTUIJTGAL-UHFFFAOYSA-N Synonym: 3-pyridin-1-ium-1-yl propane-1-sulfonate,ndsb-201,1-3-sulphonatopropyl pyridinium,unii-qn4i6ai9ek,3-1-pyridinio-1-propanesulfonate,1-pyridiniumpropane-3-sulfonate,qn4i6ai9ek,1-3-sulfopropyl pyridinium hydroxide, inner salt,pyridinium, 1-3-sulfopropyl-, inner salt,1-3-sulfonatopropyl pyridin-1-ium PubChem CID: 84929 IUPAC Name: 1-(3-sulfonatopropyl)pyridin-1-ium SMILES: [O-]S(=O)(=O)CCC[N+]1=CC=CC=C1
Apexbio Technology LLC THZ531 1702809-17-3 25mg
THZ531 (CAS 1702809-17-3) is a covalent inhibitor of cyclin-dependent kinase 12 (CDK12) and CDK13 These kinases in complex with cyclin K mediate transcription elongation and RNA processing through phosphorylation of RNA polymerase II (Pol II) THZ531 irreversibly binds to CDK12 and CDK13 exhibiting inhibitory potency (IC50) of 158 nM and 69 nM respectively while showing substantially lower affinity ( 50-fold) toward related CDK7 and CDK9 In Jurkat cells THZ531 induces apoptosis and impairs proliferation (IC50 50 nM) reducing Pol II Ser2 phosphorylation and inhibiting transcription of certain super-enhancer-linked and DNA damage response genes THZ531 serves as a research tool to investigate transcriptional regulation and associated oncogenic pathways
Apexbio Technology LLC Calcifediol 19356-17-3 100mg
Calcifediol also termed calcidiol is a hydroxylated vitamin D3 metabolite and the primary circulating form of vitamin D3 in humans Functioning as a prehormone it undergoes further hydroxylation to calcitriol which activates vitamin D receptor (VDR) signaling pathways In vitro assays indicate that calcifediol induces CYP24A1 expression (EC50 70 nM) and thrombomodulin expression at concentrations between 10-100 nM Calcifediol dose-dependently promotes nuclear translocation of VDR at concentrations from 0 1 to 10 M in cultured cells In vivo experiments demonstrated that calcifediol administration influences calcium binding protein expression and calcium transport Clinically calcifediol administration rapidly elevates circulating 25(OH)D3 concentrations facilitating precise modulation of vitamin D status Therefore calcifediol is utilized in biomedical research related to vitamin D metabolism calcium homeostasis and VDR-associated pathways
Apexbio Technology LLC Calcifediol 19356-17-3 500mg
Calcifediol also termed calcidiol is a hydroxylated vitamin D3 metabolite and the primary circulating form of vitamin D3 in humans Functioning as a prehormone it undergoes further hydroxylation to calcitriol which activates vitamin D receptor (VDR) signaling pathways In vitro assays indicate that calcifediol induces CYP24A1 expression (EC50 70 nM) and thrombomodulin expression at concentrations between 10-100 nM Calcifediol dose-dependently promotes nuclear translocation of VDR at concentrations from 0 1 to 10 M in cultured cells In vivo experiments demonstrated that calcifediol administration influences calcium binding protein expression and calcium transport Clinically calcifediol administration rapidly elevates circulating 25(OH)D3 concentrations facilitating precise modulation of vitamin D status Therefore calcifediol is utilized in biomedical research related to vitamin D metabolism calcium homeostasis and VDR-associated pathways
Apexbio Technology LLC Esmolol HCl 81161-17-3 50mg
Esmolol HCl (CAS 81161-17-3) is a cardioselective -adrenergic receptor antagonist that attenuates sympathetic stimulation of cardiac tissue By competitively inhibiting -adrenergic receptors it reduces heart rate and myocardial contractility without significant activity at -receptors Esmolol HCl is frequently employed in research to study cardiac electrophysiology autonomic regulation and pharmacological modulation of arrhythmias Its rapid onset and short duration of action make it suitable for experimental models investigating acute cardiovascular responses or -adrenergic signaling pathways
Apexbio Technology LLC SGC 0946 1561178-17-3 5mg
SGC 0946 (CAS 1561178-17-3) is a small molecule inhibitor targeting DOT1L a histone methyltransferase responsible for methylation of lysine 79 on histone H3 (H3K79) By selectively inhibiting DOT1L catalytic activity SGC 0946 disrupts H3K79 methylation showing potent inhibitory potency (IC50 0 3 nM) In cellular assays SGC 0946 reduces H3K79 methylation in MCF10A and A431 cell lines with IC50 values of 8 8 nM and 2 65 nM respectively Structurally related to EPZ004777 but as a brominated analog SGC 0946 has improved cellular permeability and prolonged target residence time facilitating research in epigenetic regulation
Apexbio Technology LLC 9-Phenanthrol 484-17-3 50mg
9-Phenanthrol (CAS 484-17-3) is a selective inhibitor of the human TRPM4 ion channel exhibiting an IC50 of approximately 20 M By specifically blocking TRPM4-mediated cation currents 9-Phenanthrol modulates calcium-dependent ionic fluxes in various cell types This compound is frequently utilized to investigate the role of TRPM4 in the regulation of ionic homeostasis and excitability in cardiomyocytes Its application enables studies on the involvement of TRPM4 in cardiac ischemia-reperfusion injury and facilitates the exploration of cardiac protective mechanisms at the cellular and molecular levels in cardiovascular research
Apexbio Technology LLC GW3965 HCl 405911-17-3 10mg
GW3965 HCl is a selective non-steroidal agonist targeting liver X receptors (LXR and LXR ) nuclear transcription factors involved in cholesterol and lipid metabolism Activation of LXRs modulates cholesterol homeostasis by enhancing cholesterol efflux from macrophages stimulating hepatic bile acid synthesis and reducing intestinal cholesterol absorption GW3965 recruits steroid receptor coactivator-1 (SRC-1) to human LXRR in vitro and functions as a full agonist on cellular assays for both LXR and LXR receptors In animal studies oral administration elevated plasma HDL cholesterol levels and increased expression of the cholesterol transporter ABCA1 in macrophages GW3965 is useful in research investigating cholesterol metabolism atherosclerosis and vascular responses mediated by Angiotensin II signaling