Pyridines and derivatives
4-Bromopyridine Hydrobromide 98.0+%, TCI America™
CAS: 74129-11-6 Molecular Formula: C5H5Br2N Molecular Weight (g/mol): 238.91 MDL Number: MFCD00060195 InChI Key: SMSVBXDZZQOTGB-UHFFFAOYSA-N PubChem CID: 44630127 IUPAC Name: 4-bromopyridine hydrobromide SMILES: Br.BrC1=CC=NC=C1
3,4-Pyridinedicarboxylic Acid 98.0+%, TCI America™
CAS: 490-11-9 Molecular Formula: C7H5NO4 Molecular Weight (g/mol): 167.12 MDL Number: MFCD00006392 InChI Key: MUYSADWCWFFZKR-UHFFFAOYSA-N Synonym: 3,4-pyridinedicarboxylic acid,cinchomeronic acid,chinchomeronic acid,3,4-pyridinedicarboxylicacid,pyridine-3,4-dicarboxylicacid,unii-7389uzw5dy,3,4-pyridindicarbons,cinchomeronsaure,pubchem2419,3,4-dicarboxypyridine PubChem CID: 10273 ChEBI: CHEBI:46860 IUPAC Name: pyridine-3,4-dicarboxylic acid SMILES: OC(=O)C1=CC=NC=C1C(O)=O
2-Methylisonicotinic Acid 98.0+%, TCI America™
CAS: 4021-11-8 Molecular Formula: C7H7NO2 Molecular Weight (g/mol): 137.14 MDL Number: MFCD00513435 InChI Key: PMDHIMMPXRSDML-UHFFFAOYSA-N Synonym: 2-methylisonicotinic acid,2-methyl-4-pyridinecarboxylic acid,2-methyl-isonicotinic acid,4-pyridinecarboxylic acid, 2-methyl,4-carboxy-2-methylpyridine,methylisonicotinic acid 2-,2-methylisonicotinicacid,acmc-20a0jw,2-methylisonicotinic aicd,6-methylpyridine-4-carboxylic acid PubChem CID: 2762821 IUPAC Name: 2-methylpyridine-4-carboxylic acid SMILES: CC1=NC=CC(=C1)C(=O)O
Citrazinic Acid 96.0+%, TCI America™
CAS: 99-11-6 Molecular Formula: C6H5NO4 Molecular Weight (g/mol): 155.11 MDL Number: MFCD00006274 InChI Key: CSGQJHQYWJLPKY-UHFFFAOYSA-N Synonym: citrazinic acid,2,6-dihydroxyisonicotinic acid,2,6-dihydroxypyridine-4-carboxylic acid,2,6-dihydroxy-4-carboxypyridine,2,6-dihydroxy-4-pyridinecarboxylic acid,kyselina citrazinova,2,6-dihydroxyisonicotinate,4-pyridinecarboxylic acid, 2,6-dihydroxy,citrazinicacid,4-pyridinecarboxylic acid, 1,2-dihydro-6-hydroxy-2-oxo PubChem CID: 7425 IUPAC Name: 6-hydroxy-2-oxo-1,2-dihydropyridine-4-carboxylic acid SMILES: OC(=O)C1=CC(=O)NC(O)=C1
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 98.0+%, TCI America™
CAS: 30652-11-0 Molecular Formula: C7H9NO2 Molecular Weight (g/mol): 139.154 MDL Number: MFCD00134497 InChI Key: TZXKOCQBRNJULO-UHFFFAOYSA-N Synonym: deferiprone,ferriprox,3-hydroxy-1,2-dimethyl-4 1h-pyridone,3-hydroxy-1,2-dimethylpyridin-4 1h-one,1,2-dimethyl-3-hydroxy-4-pyridone,1,2-dimethyl-3-hydroxypyrid-4-one,1,2-dimethyl-3-hydroxypyridine-4-one,cp20 chelating agent,unii-2bty8kh53l,ferriprox tn PubChem CID: 2972 ChEBI: CHEBI:68554 IUPAC Name: 3-hydroxy-1,2-dimethylpyridin-4-one SMILES: CC1=C(C(=O)C=CN1C)O
Methyl 2-Chloroisonicotinate 98.0+%, TCI America™
CAS: 58481-11-1 Molecular Formula: C7H6ClNO2 Molecular Weight (g/mol): 171.58 MDL Number: MFCD01765409 InChI Key: KKOUHTMLFUAAGG-UHFFFAOYSA-N Synonym: 2-Chloroisonicotinic Acid Methyl Ester, Methyl 2-Chloro-4-pyridinecarboxylate, 2-Chloro-4-pyridinecarboxylic Acid Methyl Ester PubChem CID: 2736842 IUPAC Name: methyl 2-chloropyridine-4-carboxylate SMILES: COC(=O)C1=CC(=NC=C1)Cl
Methyl 6-Methylpyridine-2-carboxylate 98.0+%, TCI America™
CAS: 13602-11-4 Molecular Formula: C8H9NO2 Molecular Weight (g/mol): 151.17 MDL Number: MFCD06203670 InChI Key: CYWIZMOZBTXFIL-UHFFFAOYSA-N Synonym: methyl 6-methylpicolinate,6-methylpyridine-2-carboxylic acid methyl ester,methyl 6-methyl-2-pyridinecarboxylate,6-methyl-pyridine-2-carboxylic acid methyl ester,6-methylpicolinic acid methyl ester,2-pyridinecarboxylic acid, 6-methyl-, methyl ester,pubchem20955,methyl-6-methylpicolinate,ksc495e0b,aronis24547 PubChem CID: 73022 IUPAC Name: methyl 6-methylpyridine-2-carboxylate SMILES: COC(=O)C1=CC=CC(C)=N1
PD 173074 95.0+%, TCI America™
CAS: 219580-11-7 Molecular Formula: C28H41N7O3 Molecular Weight (g/mol): 523.682 MDL Number: MFCD08705327 InChI Key: DXCUKNQANPLTEJ-UHFFFAOYSA-N Synonym: 1-tert-butyl-3-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea,unii-a4tll8634y,3-tert-butyl-1-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea,fgf/vegf receptor tyrosine kinase inhibitor, pd173074,1-tert-butyl-3-2-4-diethylamino butylamino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea,2fgi,1-t-butyl-3-6-3,5-dimethoxyphenyl-2-4-diethylaminobutylamino-pyrido 2,3-d pyrimidin-7-yl urea,1-tert-butyl-3-6-3,5-dimethoxy-phenyl-2-4-diethylamino-butylamino-pyrido 2,3-d pyrimidin-7-yl-urea PubChem CID: 1401 ChEBI: CHEBI:63448 IUPAC Name: 1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea SMILES: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
Apexbio Technology LLC Tetramethylpyrazine 1124-11-4 20mg
Tetramethylpyrazine (CAS 1124-11-4) a bioactive alkaloid primarily isolated from Ligusticum chuanxiong Hort exhibits multiple biological activities relevant to biomedical research Mechanistically it has been reported to modulate vascular smooth muscle contraction inhibit platelet aggregation and attenuate oxidative stress by scavenging reactive oxygen species These properties underlie its widespread application in studies of cardiovascular cerebrovascular and neurodegenerative diseases Tetramethylpyrazine can be solubilized in hot water or petroleum ether and should be stored in sealed cool and dry conditions to maintain stability during experimental use
Apexbio Technology LLC TAK-242 243984-11-4 100mg
TAK-242 (CAS 243984-11-4) also known as resatorvid is a cyclohexene derivative that functions as a selective inhibitor of Toll-like receptor 4 (TLR4) signaling Mechanistically TAK-242 binds specifically to the intracellular domain of TLR4 disrupting its interaction with downstream adaptor proteins and thus suppressing activation of inflammatory signal pathways triggered by lipopolysaccharide (LPS) In vitro TAK-242 inhibits LPS-induced production of nitric oxide TNF- and interleukin-6 in macrophages (IC50 1 1 11 nM) Preclinical animal models indicate its potential usefulness in mitigating inflammatory responses associated with neuropsychiatric conditions triggered by stress
Apexbio Technology LLC GNF 2 778270-11-4 25mg
GNF 2 (CAS 778270-11-4) is a small-molecule inhibitor targeting Bcr-Abl kinase It is designed to suppress Bcr-Abl-mediated signaling thereby regulating leukemic cell proliferation GNF 2 exerts its biological activity primarily through non-ATP competitive allosteric inhibition at the myristate-binding pocket of Abl In cell-based studies GNF 2 demonstrates inhibitory activity with an IC50 of approximately 138 nM in Ba/F3 p210 cells expressing wild-type Bcr-Abl It also inhibits mutant Bcr-Abl forms (E255V Y253H) and proliferation of K562 and SUP-B15 human leukemia cell lines with IC50 values of 194 273 nM Based on these pharmacological properties GNF 2 holds research potential in chronic myeloid leukemia (CML) pathogenesis and therapeutic response studies involving Bcr-Abl fusion proteins
Medchemexpress LLC 27-Hydroxycholesterol | 20380-11-4 | 50 MG
27-Hydroxycholesterol | 20380-11-4 | 50 MG
Medchemexpress LLC 27-Hydroxycholesterol | 20380-11-4 | 5 MG
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor. It is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. This product is intended for research use only.
- Acts as an endogenous selective estrogen receptor modulator.
- Displays significant partial agonist activity in cellular models of estrogen receptor action.
- Positively regulates gene transcription and cell proliferation in breast cancer models.
- Triggers deleterious effects in prostate cancer cell lines, increasing cell proliferation.
- Can increase breast cancer growth and metastasis.
- Levels can be modulated by statins or direct inhibition of CYP27A1 to attenuate pro-tumorigenic activities.
- 27-hydroxylation of cholesterol is a key pathway for LXR activation in response to cholesterol overload.
Medchemexpress LLC 27-Hydroxycholesterol | 20380-11-4 | 25 MG
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor. It is an endogenous oxysterol that regulates intracellular cholesterol homeostasis and is intended for research use only.
- Acts as an endogenous selective estrogen receptor modulator
- Functions as an agonist of the liver X receptor
- Positively regulates gene transcription and cell proliferation in breast cancer models
- Increases cell proliferation in LNCaP and PC3 cells
- Produced from cholesterol by monooxygenase CYP27A1
- Levels can be modulated by statins or CYP27A1 inhibition
- Important for LXR activation in response to cholesterol overload