Pyridines and derivatives
Medchemexpress LLC Tolrestat | 82964-04-3 | 99.4% | 357.35 | 1 ML
Tolrestat is a potent, orally active aldose reductase inhibitor. It is supplied as a 10 mM solution in 1 mL of DMSO, ready for reconstitution.
- Potent and orally active aldose reductase inhibitor
- Has an IC50 of 35 nM
- Supplied as a 10 mM solution in 1 mL of DMSO
- Normalizes RBC sorbitol levels in diabetic rats in in vivo studies
- Inhibits tissue AR activity without affecting plasma lipoprotein levels or body weight
Medchemexpress LLC Tolrestat | 82964-04-3 | 99.4% | 357.35 | 50 MG
Tolrestat is a potent, orally active aldose reductase inhibitor with an IC50 of 35 nM.
- Potent, orally active aldose reductase inhibitor with IC50 of 35 nM.
- Causes a reversal to normal RBC sorbitol levels in diabetic rats at 1.8 mg/kg per day.
- Inhibits tissue AR activity without significantly affecting plasma lipoprotein levels or body weight in mice.
Medchemexpress LLC Tolrestat | 82964-04-3 | 99.4% | 357.35 | 25 MG
Tolrestat is a potent, orally active aldose reductase inhibitor with an IC50 of 35 nM. It is intended for research use only.
- Potent, orally active aldose reductase inhibitor.
- IC50: 35 nM (Aldose Reductase).
- Causes a reversal to normal RBC sorbitol levels in diabetic rats.
- Inhibits tissue AR activity without significantly affecting plasma lipoprotein levels, body weight, or general health in mice.
![Medchemexpress LLC N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine | 82964-04-3 | 99.4% | 357.35 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000394210.png-250.jpg)
Medchemexpress LLC N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine | 82964-04-3 | 99.4% | 357.35 | 100 MG
Tolrestat is a potent, orally active aldose reductase inhibitor with an IC50 of 35 nM. It has been shown to reverse elevated red blood cell sorbitol levels in diabetic rats. Studies in diabetic rats have also indicated its inhibitory effect on tissue aldose reductase activity in the sciatic nerve and lenses. Tolrestat does not significantly affect plasma lipoprotein levels, body weight, or general health in mice.
- Potent and orally active aldose reductase inhibitor.
- Exhibits an IC50 of 35 nM.
- Reverses high red blood cell sorbitol levels in diabetic rats.
- Inhibits aldose reductase activity in sciatic nerve and lenses.
- Does not significantly impact plasma lipoprotein levels.
Medchemexpress LLC N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methylglycine | 82964-04-3 | ≥98.0% | 357.35 g/mol | C16H14F3NO3S | 10 MG
Tolrestat is a potent, orally active aldose reductase inhibitor (IC50 = 35 nM) supplied as a purified research standard for biochemical and pharmacological studies. The compound has formula C16H14F3NO3S, molecular weight 357.35 g/mol, and CAS 82964-04-3. Solubility: DMSO 50 mg/mL; aqueous formulations ≥ 2.5 mg/mL with appropriate solubilizers. Storage: powder at -20°C (up to 3 years); solutions at -80°C (up to 2 years).
- Potent aldose reductase inhibition (IC50 = 35 nM).
- Suitable as an analytical standard for in vitro assays.
- Good solubility in DMSO and formulatable for aqueous use.
- Long-term stability when stored under recommended conditions.
- Defined chemical identity and molecular properties for reproducible results.
2,3-Dihydroxypyridine 99.0+%, TCI America™
CAS: 16867-04-2 Molecular Formula: C5H5NO2 Molecular Weight (g/mol): 111.1 MDL Number: MFCD00006271 InChI Key: GGOZGYRTNQBSSA-UHFFFAOYSA-N Synonym: 2,3-dihydroxypyridine,2,3-pyridinediol,pyridine-2,3-diol,3-hydroxy-2-pyridone,2 1h-pyridinone, 3-hydroxy,3-hydroxy-2 1h-pyridinone,3-hydroxypyridin-2 1h-one,2 1h-pyridone, 3-hydroxy,hydroxypyridone,unii-7hy4bcj130 PubChem CID: 28115 IUPAC Name: 3-hydroxy-1H-pyridin-2-one SMILES: C1=CNC(=O)C(=C1)O
2-Amino-3-chloropyridine 98.0+%, TCI America™
CAS: 39620-04-7 Molecular Formula: C5H5ClN2 Molecular Weight (g/mol): 128.559 MDL Number: MFCD03541052 InChI Key: RZJPBQGRCNJYBU-UHFFFAOYSA-N Synonym: 2-amino-3-chloropyridine,3-chloro-pyridin-2-ylamine,2-amino-3-chloro pyridine,3-chloro-2-pyridinamine,3-chloro-2-pyridinylamine,2-pyridinamine, 3-chloro,3-chloro-2-pyridylamine,2-amino-3-chloro-pyridine,3-chloranylpyridin-2-amine,o-aminochloropyridine PubChem CID: 693267 IUPAC Name: 3-chloropyridin-2-amine SMILES: C1=CC(=C(N=C1)N)Cl
2-Chloro-3-fluoropyridine 98.0+%, TCI America™
CAS: 17282-04-1 Molecular Formula: C5H3ClFN Molecular Weight (g/mol): 131.534 MDL Number: MFCD03095302 InChI Key: SVAZIMBLBHOVIR-UHFFFAOYSA-N Synonym: 3-fluoro-2-chloropyridine,2-chloro-3-fluoro pyridine,pyridine, 2-chloro-3-fluoro,2-chloro-3-fluoro-pyridine,pubchem2532,acmc-1cc0d,ksc174s3h,2-chloro-3-fluoropyridine,2-chloro-3-fluoropyridine 1g PubChem CID: 2782791 IUPAC Name: 2-chloro-3-fluoropyridine SMILES: C1=CC(=C(N=C1)Cl)F
5-Bromonicotinic Acid 99.0+%, TCI America™
CAS: 20826-04-4 Molecular Formula: C6H4BrNO2 Molecular Weight (g/mol): 202.01 MDL Number: MFCD00009783 InChI Key: FQIUCPGDKPXSLL-UHFFFAOYSA-N Synonym: 5-bromonicotinic acid,5-bromo nicotinic acid,5-bromo-3-pyridinecarboxylic acid,3-pyridinecarboxylic acid, 5-bromo,nicotinic acid, 5-bromo,5-bromo-nicotinic acid,3-bromo-5-pyridine carboxylic acid,3-bromo pyridine-5-carboxylic acid,pubchem1211,acmc-209fev PubChem CID: 88707 IUPAC Name: 5-bromopyridine-3-carboxylic acid SMILES: OC(=O)C1=CN=CC(Br)=C1
Apexbio Technology LLC SAR191801 1234708-04-3 50mg
SAR191801 (CAS 1234708-04-3) is a selective inhibitor of human hematopoietic prostaglandin D synthase (hPGDS) By targeting and suppressing hPGDS enzymatic activity SAR191801 effectively reduces the synthesis of prostaglandin D (PGD ) In fluorescence polarization and enzyme immunoassay experiments it demonstrated an IC value of 12 nM for hPGDS inhibition SAR191801 serves as a valuable tool for studying physiological processes and pathologies mediated by PGD including allergic reactions inflammatory responses and sleep-wake regulation mechanisms
Apexbio Technology LLC SAR191801 1234708-04-3 10mg
SAR191801 (CAS 1234708-04-3) is a selective inhibitor of human hematopoietic prostaglandin D synthase (hPGDS) By targeting and suppressing hPGDS enzymatic activity SAR191801 effectively reduces the synthesis of prostaglandin D (PGD ) In fluorescence polarization and enzyme immunoassay experiments it demonstrated an IC value of 12 nM for hPGDS inhibition SAR191801 serves as a valuable tool for studying physiological processes and pathologies mediated by PGD including allergic reactions inflammatory responses and sleep-wake regulation mechanisms
Apexbio Technology LLC SAR191801 1234708-04-3 5mg
SAR191801 (CAS 1234708-04-3) is a selective inhibitor of human hematopoietic prostaglandin D synthase (hPGDS) By targeting and suppressing hPGDS enzymatic activity SAR191801 effectively reduces the synthesis of prostaglandin D (PGD ) In fluorescence polarization and enzyme immunoassay experiments it demonstrated an IC value of 12 nM for hPGDS inhibition SAR191801 serves as a valuable tool for studying physiological processes and pathologies mediated by PGD including allergic reactions inflammatory responses and sleep-wake regulation mechanisms
Apexbio Technology LLC Temsirolimus 162635-04-3 50mg
Temsirolimus (CCI-779) is an ester analog of rapamycin functioning as an inhibitor of the mammalian target of rapamycin (mTOR) The compound suppresses mTOR signaling pathways thus inhibiting cellular proliferation and growth In preclinical studies on breast cancer cell lines Temsirolimus displayed inhibitory activities with reported IC50 values of 0 6 nM in BT-474 cells 0 7 nM in MDA-MB-468 and SKBR-3 cells and 50 nM in MCF-7 cells It has been examined in xenograft models of tumors with PTEN mutations and multiple myeloma for investigating pathways related to cell-cycle progression and proliferation regulated by mTOR
Apexbio Technology LLC Temsirolimus 162635-04-3 25mg
Temsirolimus (CCI-779) is an ester analog of rapamycin functioning as an inhibitor of the mammalian target of rapamycin (mTOR) The compound suppresses mTOR signaling pathways thus inhibiting cellular proliferation and growth In preclinical studies on breast cancer cell lines Temsirolimus displayed inhibitory activities with reported IC50 values of 0 6 nM in BT-474 cells 0 7 nM in MDA-MB-468 and SKBR-3 cells and 50 nM in MCF-7 cells It has been examined in xenograft models of tumors with PTEN mutations and multiple myeloma for investigating pathways related to cell-cycle progression and proliferation regulated by mTOR