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Filtered Search Results
Apexbio Technology LLC Rofecoxib 162011-90-7 250mg
Rofecoxib (CAS 162011-90-7) is a selective inhibitor of cyclooxygenase-2 (COX-2) designed to provide anti-inflammatory effects with improved gastrointestinal tolerance compared to non-selective NSAIDs It demonstrates potent inhibition of COX-2 in cell-based assays with IC50 values ranging from 18 to 46 nM In osteosarcoma cells Rofecoxib suppresses prostaglandin E2 (PGE2) synthesis (IC50 26 nM) and inhibits recombinant human COX-2 in stably transfected CHO cells (IC50 18 nM) In biochemical assays using purified human COX-2 the IC50 is 0 34 M In vivo Rofecoxib reduces carrageenan-induced edema and hyperalgesia in rats (ID50 1 1 5 mg/kg) It is widely used in studies investigating COX-2-mediated inflammatory pathways and analgesia
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Apexbio Technology LLC kobe2602 454453-49-7 250mg
Kobe2602 (CAS 454453-49-7) is a small molecule inhibitor identified through computational screening as a modulator of Ras signaling Kobe2602 impedes the interaction between mutant Ras proteins (H-RasG12V) and c-Raf-1 in NIH 3T3 cells with an IC50 of 10 M and exhibits a Ki of 149 M for Ras inhibition At concentrations of 20 M kobe2602 suppresses the phosphorylation of downstream kinases MEK and ERK In NIH 3T3 cells expressing H-rasG12V it inhibits colony formation with an IC50 of 1 4 M The compound demonstrates growth-inhibitory effects across multiple cancer cell lines harboring activated Ras and in mouse xenograft models administration of 80 mg/kg results in 40 50% tumor growth inhibition Kobe2602 serves as a valuable tool for studying Ras-dependent signaling and oncogenesis
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Medchemexpress LLC Glutathione ethyl ester | 92614-59-0 | MFCD00156117 | 95.8% | 335.38 g·mol⁻¹ | C12H21N3O6S | 5 MG
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Glutathione ethyl ester is a cell-permeable glutathione (GSH) donor used to raise intracellular GSH levels and enhance antioxidative defenses in cell culture and reproductive biology applications.
- Cell-permeable glutathione donor
- Increases intracellular GSH levels
- Enhances antioxidative defense in cultured cells and oocytes
- Supports in vitro embryo and oocyte culture applications
- Supplied as a solid powder for dissolution into media
- Purity 95.8% as listed
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Medchemexpress LLC PROPOFOL IMPURITY 1 250MG
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5000204519 PROPOFOL IMPURITY 1 250MG
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Medchemexpress LLC 3 -TBDMS-ibu-rG Phos 250mg
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3 -TBDMS-ibu-rG Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides
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![eMolecules 271-70-5 | 7H-Pyrrolo[2,3-d]pyrimidine | Ambeed | MFCD08234403 | 119.127 | C6H5N3 | 98.000 | c1cc2cncnc2[nH]1 | 100g | 515726195](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000280422.jpg-250.jpg)
eMolecules 271-70-5 | 7H-Pyrrolo[2,3-d]pyrimidine | Ambeed | MFCD08234403 | 119.127 | C6H5N3 | 98.000 | c1cc2cncnc2[nH]1 | 100g | 515726195
7H-Pyrrolo[2,3-d]pyrimidine | Ambeed | 271-70-5 | MFCD08234403 | 119.127 | C6H5N3 | 98.000 | c1cc2cncnc2[nH]1 | 100g | 515726195
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Medchemexpress LLC MORINIDAZOLE 250 mg
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MORINIDAZOLE 250MG
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Selleck Chemical LLC Thiamine nitrate
Thiamine (Vitamin B1) nitrate is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives
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Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 10mM (in 1mL DMSO)
Regorafenib monohydrate (CAS 1019206-88-2) is a multitargeted tyrosine kinase inhibitor that suppresses numerous intracellular and membrane receptor tyrosine kinases (RTKs) including VEGFR (types 1-3) PDGFR- FGFR-1 RET TIE2 c-KIT Raf-1 and BRAF (wild-type and V600E mutant) It inhibits angiogenic RTKs such as VEGFR-2 with IC50 values ranging from approximately 4 2 to 46 nM and oncogenic RTKs like c-KIT and RET with IC50 values around 1 5 to 28 nM Regorafenib demonstrates antiproliferative activity in vitro (mean IC50 1 M) and reduces tumor progression in xenograft animal models supporting its use in cancer research involving breast colorectal thyroid pancreatic cancers melanoma and gastrointestinal stromal tumors
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Medchemexpress LLC Ethyl cellulose 1kg
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Ethyl cellulose is a derivative of cellulose Ethyl cellulose is a non-toxic biodegradable polymer Ethyl cellulose has unique properties such as oil gel formation active ingredient delivery and film formation Ethyl cellulose can be used as a pharmaceutical excipient such as a coating agent flavoring agent tablet filler etc Ethyl cellulose can be used to prepare nanoparticles for active compound delivery[1][2][3][4]
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![eMolecules 3680-69-1 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | ChemScene | MFCD01686865 | 153.570 | C6H4ClN3 | 98.000 | Clc1ncnc2[nH]ccc12 | 5g | 346740829](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000224382.jpg-250.jpg)
eMolecules 3680-69-1 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | ChemScene | MFCD01686865 | 153.570 | C6H4ClN3 | 98.000 | Clc1ncnc2[nH]ccc12 | 5g | 346740829
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | ChemScene | 3680-69-1 | MFCD01686865 | 153.570 | C6H4ClN3 | 98.000 | Clc1ncnc2[nH]ccc12 | 5g | 346740829
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![Medchemexpress LLC 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine | 251647-50-4 | MFCD03428520 | 95.0% | 713.78 | C38H43N5O9 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000284398.png-250.jpg)
Medchemexpress LLC 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine | 251647-50-4 | MFCD03428520 | 95.0% | 713.78 | C38H43N5O9 | 5 G
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5'-O-DMT-N2-Ibu-2'-OMe-G is a protected guanosine nucleoside intermediate used in the chemical synthesis of modified oligonucleotides and nucleic acid research. It contains a 5'-O-DMT protecting group, an N2-isobutyryl modification, and a 2'-O-methoxyethyl substitution. Supplied as a purified solid (formula C38H43N5O9; molecular weight 713.78; purity 95.0% by NMR).
- Protected guanosine intermediate for oligonucleotide synthesis.
- Contains 5'-O-DMT, N2-isobutyryl, and 2'-O-methoxyethyl groups.
- High reported purity suitable for research applications.
- Intended for use as a building block in modified oligonucleotide assembly.
- Offered in laboratory-friendly premeasured quantities.
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Medchemexpress LLC Ethyl 2-chloroacetoacetate | 609-15-4 | MFCD00009141 | 164.59 | C6H9ClO3 | 100g
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Ethyl 2-chloroacetoacetate (A 21960) is a Tn3 resolvase inhibitor and inhibit synapse formation between resolvase and two directly repeated res sites[1]
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Medchemexpress LLC 5-Cholanic acid 500mg
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5 -Cholanic acid is a hydrophobic modifier used to modify polymer carriers 5 -Cholanic acid can improve the acid stability cell penetration efficiency and drug sustained release ability of nanocarriers and optimize the oral effectiveness of delivered molecules 5 -Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells) 5 -Cholanic acid can be used in the development of drug delivery systems[1][2]
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Medchemexpress LLC Ethyl 2-Hydroxybutyr 10g
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Ethyl 2-Hydroxybutyrate has a sweet fruity odor and is commonly used as a flavoring agent in the food and beverage industry In addition it can be used as an intermediate in the synthesis of various organic compounds including fragrances pharmaceuticals and agrochemicals Its unique chemical properties make it an important ingredient in a variety of industrial processes notably in the production of cosmetics personal care products and cleaning agents
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