Pyrimidines And Derivatives
Medchemexpress LLC Flumethasone | 2135-17-3 | 99.8% | 250 MG
Flumethasone (Flumetasone) is an orally active, highly selective and potent glucocorticoid receptor (GR) agonist. It activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10). It also regulates metabolic enzyme activity, such as tyrosine aminotransferase induction. Flumethasone shows promise for research into inflammatory diseases, cancer, and endocrine regulation.
- Orally active
- High selective and potent glucocorticoid receptor (GR) agonist
- Inhibits NF-κB-mediated pro-inflammatory cytokine production (TNF-α, IL-1β)
- Promotes anti-inflammatory gene expression (IL-10)
- Regulates metabolic enzyme activity (tyrosine aminotransferase induction)
- Promising for research of inflammatory diseases, cancer, and endocrine regulation
Medchemexpress LLC BAM 15 | 210302-17-3 | 99.8% | 340.29 | 250 MG
BAM 15 is a mitochondrial protonophore uncoupler and an oxidative phosphorylation (OXPHOS) uncoupler. It offers several benefits for research applications.
- Increases O2 consumption without increasing reactive oxygen species.
- Maintains uncoupled respiration at high rates across a broad concentration range.
- Fully increases mitochondrial respiration in the presence of oligomycin.
- Induces mitochondrial swelling.
- Treated cells are more viable than FCCP-treated cells across a broad dosing range.
- Protects from kidney injury in vivo, reducing tubular necrosis and immune cell infiltration.
Medchemexpress LLC 9-Hydroxyphenanthrene | 484-17-3 | 98.6% | 194.23 | 250 MG
9-Phenanthrol (9-Hydroxyphenanthrene) is a selective TRPM4 inhibitor with an IC50 of 17 μM. It demonstrates no inhibitory activity on TRPM5, TRPC6, and CFTR. This compound can be utilized for research into ischemia-reperfusion injury, with studies showing it can reduce myocardial dysfunction in isolated rat hearts subjected to ischemia and reperfusion.
- Selective TRPM4 inhibitor with an IC50 of 17 μM.
- Shows no inhibitory activity on TRPM5, TRPC6, and CFTR.
- Useful for research into ischemia-reperfusion injury.
- Can reduce myocardial dysfunction in isolated rat hearts.
- Leads to significant improvement in heart function.
- Reduces infarct size in affected hearts.
Medchemexpress LLC N-succinimidyl 3-(2-pyridyldithio)propionate | 68181-17-9 | MFCD00009636 | 99.1% | 312.37 g/mol | C12H12N2O4S2 | 250 MG
SPDP is a short-chain, heterobifunctional crosslinker (N-succinimidyl 3-(2-pyridyldithio)propionate) that contains an NHS ester and a pyridyldithiol group. It enables formation of a cleavable disulfide linkage between primary amines and sulfhydryls, making it suitable for reversible bioconjugation, protein labeling, and linker applications requiring reduction-sensitive release.
- Enables amine-to-sulfhydryl conjugation via NHS ester and pyridyldithiol.
- Forms cleavable disulfide bonds reducible by intracellular glutathione.
- Short spacer arm minimizes steric interference in conjugates.
- Suitable for antibody-drug conjugates and reversible protein labeling.
- Provided as a high-purity solid for biochemical reactions.
eMolecules Chemodex Ltd N-Succinimidyl 3-(2-pyridyldithio)propionate 25mg 849672892 S0019 97 000 68181-17-9 MFCD00009636 312 360 C12H12N2O4S2
Chemodex Ltd N-Succinimidyl 3-(2-pyridyldithio)propionate 25mg 849672892 S0019 97 000 68181-17-9 MFCD00009636 312 360 C12H12N2O4S2
Selleck Chemical LLC Ethyl Vanillate S3993-25mg
Ethyl vanillin (Bourbonal Ethylprotal) a vanillin analog is a flavouring agent and a fungicidal agent that exhibits strong antioxidant activity Ethyl Vanillate inhibits 17 -HSD2 with an IC50 1 3 M
Research Products International Corp Imipenem Monohydrate 100 MG
- CAS Number: 74431-23-5
- Molecular Formula: C12H17N3O4S • H2O
- Molecular Weight: 317.36
Medchemexpress LLC 17-hydroxyheptadecanoic acid | 13099-34-8 | MFCD00506157 | 99.7% | 286.45 g/mol | C17H34O3 | 250MG
17-hydroxyheptadecanoic acid is a 17-carbon ω-hydroxy fatty acid supplied as a white to off-white solid intended for research use in lipid metabolism studies and analytical workflows. The material is accompanied by a batch certificate of analysis reporting 99.70% purity (HPLC), and includes molecular formula C17H34O3 and molecular weight 286.45 g/mol. Recommended storage: room temperature for the solid (up to 3 years); in solvent store at -80°C (2 years) or -20°C (1 year).
- High purity suitable for analytical and research applications.
- Batch certificate of analysis available for traceable quality.
- Solid form is convenient for weighing and storage.
- Storage conditions specified for solid and solvent forms.
- Molecular formula and molecular weight provided for method development.
- CAS number 13099-34-8 enables precise identification.
Cayman Chemical ThIobarbIturIc AcId asy Rea 1g
A multi-kinase inhibitor inhibits FLT3 CSF1R c-Kit FGFR1 FGFR3 VEGFR1 -2 and -3 PDFGRa and PDGFRB (IC50s 1 36 2 8 9 10 13 8 27 and 210 nM respectively) inhibits the proliferation of human multiple myeloma cell lines expressing mutant but not wild-type FGFR3 (IC50s 90-550 and >2500 nM respectively) decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM inhibits bFGF-induced angiogenesis in a Matrigel™ plUG assay in mice at 3-300 mg/kg for 8 days reduces tumor growth in KM12L4A DU145 and MV4-11 mouse xenograft models (ED50s 17 23 and 3 mg/kg per day respectively)