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Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.
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2

Apexbio Technology LLC Calcipotriol monohydrate 147657-22-5 100mg
SDP

Calcipotriol monohydrate (CAS 147657-22-5) is a synthetic analog of vitamin D3 designed to modulate keratinocyte activity It acts by binding to the vitamin D receptor leading to inhibition of keratinocyte proliferation and induction of their physiological differentiation These effects collectively reduce abnormal epidermal growth and the formation of scaling plaques Calcipotriol monohydrate is widely utilized in biomedical research to investigate the regulation of epidermal differentiation vitamin D receptor-mediated signaling and the pathophysiology of disorders such as psoriasis

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3

Medchemexpress LLC Picoxystrobin | 117428-22-5 | 99.8% | 367.32 | 250 MG
SDP

Picoxystrobin is a strobilurin fungicide that controls plant diseases by inhibiting mitochondrial respiration. It has been shown to be highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity. This product is for research use only.

  • Controls plant diseases by inhibiting mitochondrial respiration
  • Can cause developmental abnormalities, oxidative stress, and immunotoxicity in zebrafish embryos
  • For research use only

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4

eMolecules​ 2-Methyl-4,6-dihydroxypyrimidine | 1194-22-5 | MFCD00006104 | 25g

Oakwood Chemical | 2-Methyl-4,6-dihydroxypyrimidine | 25g | 537687442 | 036424 | | 1194-22-5 | MFCD00006104 | 126.115 | C5H6N2O2

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5

Medchemexpress LLC Moschamine | 193224-22-5 | 98.1% | 352.38 g/mol | C20H20N2O4 | 250 MG
SDP

Moschamine is an endogenous metabolite supplied for research use that inhibits excessive mitochondrial superoxide production. It is provided as a solid for in vitro research applications and is not for human or clinical use.

  • Inhibits excessive mitochondrial superoxide production.
  • High reported purity of 98.1%.
  • Molecular weight 352.38 g/mol and formula C20H20N2O4.
  • Soluble in DMSO at approximately 100 mg/mL; ultrasonic assistance may be required.
  • Stable as a solid at room temperature (3 years); in solvent: -80°C (2 years), -20°C (1 year).
  • Available in multiple pack sizes, including a 250 mg vial for convenient handling.

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6

eMolecules​ ChemScene / Ethyl [22-bipyrimidine]-5-carboxylate / 100mg / 714287512 / CS-0438504 / 0.000 / 1068977-22-9 / MFCD25542251 / 230.227 / C11H10N4O2

ChemScene / Ethyl [22-bipyrimidine]-5-carboxylate / 100mg / 714287512 / CS-0438504 / 0.000 / 1068977-22-9 / MFCD25542251 / 230.227 / C11H10N4O2

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7

Medchemexpress LLC 5-methyl-2-(pyrimidin-2-yl)benzoic acid | 1088994-22-2 | MFCD14706695 | 214.22 | 50 G
SDP

5-methyl-2-(pyrimidin-2-yl)benzoic acid is a chemical intermediate primarily utilized in the synthesis of anticancer drugs. This compound is typically found as a white to off-white solid.

  • White to off-white solid appearance
  • Molecular formula C12H10N2O2
  • Molecular weight 214.22
  • Boiling point 316 °C
  • Density 1.260
  • Flash point 145 °C
  • Heavy atoms count: 16
  • Rotatable bond count: 2
  • Number of rings: 2
  • Polar surface area: 63 Å2
  • Hydrogen bond acceptors count: 4
  • Hydrogen bond donors count: 1

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8

Medchemexpress LLC Pki 14-22 amide,myristoylated | 201422-03-9 | 99.65% | 1209.49 | 5 MG
SDP

Pki 14-22 amide,myristoylated | 201422-03-9 | 99.65% | 1209.49 | 5 MG

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9

eMolecules​ Uracil-5-boronic acid | Combi-Blocks | 70523-22-7 | MFCD01318983 | 155.900 | C4H5BN2O4 | 96.000 | OB(O)c1c[nH]c(=O)[nH]c1=O | 250mg | 482933537

Uracil-5-boronic acid | Combi-Blocks | 70523-22-7 | MFCD01318983 | 155.900 | C4H5BN2O4 | 96.000 | OB(O)c1c[nH]c(=O)[nH]c1=O | 250mg | 482933537

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10

Medchemexpress LLC HY-101563 10mg Medchemexpress, GSK3326595 CAS:1616392-22-3 Purity:>98%
SDP

Medchemexpress, HY-101563 10mg GSK3326595 CAS:1616392-22-3 GSK3326595 (EPZ015938) is a potent, selective, reversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 6.2 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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11

Apexbio Technology LLC AZ20 1233339-22-4 5mg
SDP

AZ20 (CAS 1233339-22-4) is a potent and selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) protein kinase In biochemical assays AZ20 inhibits ATR with an IC50 of 5 nM in HeLa nuclear extracts and suppresses ATR-mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma cells with an IC50 of 50 nM The compound displays high selectivity for ATR over related kinases such as PI3K isoforms ATM and DNA-PK and minimal activity against mTOR In preclinical models AZ20 demonstrates significant inhibition of tumor growth in LoVo colorectal cancer xenografts following oral administration AZ20 serves as a valuable chemical probe for studying ATR function and the therapeutic potential of ATR inhibition in cancer research

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