Pyrroles
Enzo Life Sciences ET B receptor antagonist. sodium salt (1mg). CAS: 156161-89-6
Highly potent and selective ETB-receptor antagonist. Alternative name: BQ-788 . Na. Formula: C34H50N5O7Na. MW: 663.7. Purity: ≥95% (HPLC). Formulation: Lyophilized from 0.1M sodium bicarbonate. Solubility: Soluble in methanol (0.5mg/ml), DMSO (4mg/ml), 0.1M sodium bicarbonate (3mg/ml) or 100% ethanol (4mg/ml); insoluble in water. Long Term Storage: -20°C.
Cayman Chemical Losartn CarboxylIc AcId 50mg
An AT1b receptor antagonist and active metabolite of losartan; an antagonist of AT1b (Kis = 0.67 nM in COS-7 cells expressing the human receptor); selective for AT1b over AT2 (Ki = >10,000 nM in COS-7 cells expressing the human receptor); reduces U-44619-induced aggregation of platelets in isolated human platelet-rich plasma at 50 µM; reduces MAP in water-deprived rats at 1 mg/kg
Enzo Life Sciences ET B receptor antagonist. sodium salt (0.5mg). CAS: 156161-89-6
Highly potent and selective ETB-receptor antagonist. Alternative name: BQ-788 . Na. Formula: C34H50N5O7Na. MW: 663.7. Purity: ≥95% (HPLC). Appearance: White to off-white powder. Formulation: Lyophilized from 0.1M sodium bicarbonate. Peptide content: 75-95%. Solubility: Soluble in methanol (0.5mg/ml), DMSO (4mg/ml), 0.1M sodium bicarbonate (3mg/ml) or 100% ethanol (4mg/ml); insoluble in water. Long Term Storage: -20°C.
AdipoGen Sunitinib . malate (500 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
AdipoGen Sunitinib . malate (25 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
AdipoGen Sunitinib . malate (5 mg)
Chemical. CAS: 341031-54-7. Formula: C22H27FN4O2 . C4H6O5. MW: 398.5 . 134.1. Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
AdipoGen L-Homoserine lactone HCl
Chemical. CAS 2185-03-7. Formula C4H7NO2 . HCl. MW 137.56. L-Homoserine lactone is a synthetic building block or intermediate used in the synthesis of organoselenium chemistry intermediates and analogs of bacterial quorum-sensing signaling molecules.
Medchemexpress LLC UNC2025 hydrochloride | 2070015-17-5 | MFCD28963885 | 100.0% | 513.12 g/mol | C28H41ClN6O | 5MG
UNC2025 hydrochloride is a small-molecule, ATP-competitive inhibitor of Mer and FLT3 kinases with low-nanomolar potency and favorable pharmacokinetic properties; it is provided for research use in studies of Mer/FLT3 signaling and leukemia models.
- Potent Mer/FLT3 inhibitor with IC50 values in the sub-nanomolar to low-nanomolar range.
- Demonstrates selectivity for MERTK relative to Axl.
- High reported purity suitable for research applications.
- Solid, light yellow to yellow physical form for easy handling and storage.
- Manufacturer-reported solubility in DMSO, water, and PBS for formulation flexibility.
- Storage recommendations provided for stability in solution and solid state.
Medchemexpress LLC Hlcl-61 hydrochloride | 1158279-20-9 | 99.9% | 380.91 | C23H25ClN2O | 5 MG
HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) used for research to probe PRMT5-mediated methylation and cellular responses. It reduces cell growth in a dose-dependent manner across multiple leukemia cell lines and inhibits symmetric arginine dimethylation of histones H3 and H4, supporting studies of epigenetic regulation and oncology research.
- Targets PRMT5 to inhibit arginine methylation.
- Reduces cell proliferation in leukemia cell lines; IC50s reported by manufacturer.
- High purity suitable for research applications.
- Soluble in DMSO (50 mg/mL); insoluble in water.
- Solid, white to off-white appearance; store sealed away from moisture under recommended conditions.
Medchemexpress LLC 1H-Pyrrole-2-carboxylic acid | 634-97-9 | MFCD00005219 | 111.10 | 10 G
Pyrrole-2-carboxylic acid is a natural alkaloid derived from the marine bacterium *Pelomonas puraquae sp. Nov*. It represents a biological form of pyrrole commonly found in natural compounds. This substance serves as a precursor in biosynthetic processes for various pyrrole derivatives, including clorobiocin, coumermycin A1, pyoluteorin, leupyrrins, and undecylprodigiosin.
- Store powder at -20°C for up to 3 years or at 4°C for up to 2 years.
- Store in solvent at -80°C for up to 6 months or at -20°C for up to 1 month.
- For solutions in water, dilute to working solution, then filter and sterilize with a 0.22 μm filter prior to use.
- For *in vivo* experiments, prepare working solutions freshly and use them on the same day.
- Exercise caution in protocol selection if the continuous dosing period extends beyond half a month.