Quinolines and derivatives
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Filtered Search Results
eMolecules 58794-09-5 | 7-Bromoisoquinoline | Ambeed | MFCD07368661 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2ccncc2c1 | 10g | 525052807
7-Bromoisoquinoline | Ambeed | 58794-09-5 | MFCD07368661 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2ccncc2c1 | 10g | 525052807
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Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | MFCD00017694 | 1 ML
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from *Glycyrrhiza uralensis*. It acts as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound can consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production.
- Inhibits MUC5AC gene expression
- Reduces mucus production and secretion
- Regulates NF-κB, STAT6, and HDAC2 pathways
- Decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with an IC50 value of 1.4 μM
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Medchemexpress LLC Amentoflavone 7,4',7'',4'''-tetramethyl ether | 3778-25-4 | 1 MG
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Amentoflavone 7,4',7'',4'''-tetramethyl ether is a biflavone, a natural product that can be isolated from Selaginella moellendorffii. It is intended for research use only.
- Molecular weight: 594.56
- Formula: C34H26O10
- Appearance: Solid
- Color: Off-white to yellow
- Purity: 97.0%
- Structure classification: Flavonoids, biflavones
- Initial source: Plants (Selaginella moellendorffii Hieron.)
- Natural product with potential selective cytotoxicity
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Medchemexpress LLC Dihydroergocristine (mesylate) | 24730-10-7 | 5 MG
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Dihydroergocristine mesylate (DHEC mesylate) is a γ-secretase (GSI) inhibitor. It is known for its ability to reduce the production of Alzheimer's disease amyloid-β peptides by binding directly to γ-secretase and Nicastrin.
- Inhibits γ-secretase (GSI)
- Reduces production of amyloid-β peptides
- Binds directly to γ-secretase and Nicastrin with Kd values of 25.7 nM and 9.8 μM, respectively
- Exhibits an IC50 value of 25 μM for inhibiting γ-secretase activity in T100 cells without affecting cell viability
- Inhibits cellular Aβ production
- Causes dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293
- Decreases γ-secretase activity in fibroblast cells
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Medchemexpress LLC Dihydralazine (sulfate) | 7327-87-9 | 25 MG
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Dihydralazine sulfate is a vasodilator and an antihypertensive agent. In vivo studies have shown that it inhibits haemorrhagic hypotension in rats with renal hypertension (RHR) and spontaneous hypertension (SHR) without causing a concomitant fall in cerebral blood flow (CBF) when administered intravenously at single doses ranging from 0.1 to 2 mg/kg.
- Acts as a vasodilator
- Functions as an antihypertensive agent
- Inhibits haemorrhagic hypotension in hypertensive rats without reducing cerebral blood flow
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Medchemexpress LLC 7,4'-Di-O-methylapigenin | 5128-44-9 | 25 MG
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7,4'-Di-O-methylapigenin is a flavonoid found in Lethedon tannaensis. It exhibits cytotoxicity against human nasopharyngeal carcinoma cells. This product is for research use only and not intended for human use. It appears as a solid with a light brown to yellow color.
- Flavonoid present in Lethedon tannaensis
- Exhibits cytotoxicity against human nasopharyngeal carcinoma cells
- Inhibits the growth of human nasopharyngeal carcinoma (KB) cells with an IC50 value of 55 μM
- For research use only
- Appears as a light brown to yellow solid
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Medchemexpress LLC 31-Norlanostenol | 16910-39-7 | 25 MG
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31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. It acts as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor.
- Molecular weight: 414.71
- Formula: C29H50O
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, triterpenes
- Initial source: Plants, Euphorbiaceae, Euphorbia boetica
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Medchemexpress LLC Exendin-3/4 (59-86) Pedin-3/4 (59-86 | 1263874-37-8 | 98.2% | 3055.42 | 5 MG
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Exendin-3/4 (59-86) is a derivative of Exendin-4 peptide. Exendin-4 itself is a pure GLP-1 receptor agonist. Exendin-4 peptide derivatives are structurally derived from Exendin-4 and may be related to dual GLP-1/glucagon receptor agonists.
- Peptide derivative.
- Structurally derived from Exendin-4.
- May relate to dual GLP-1/glucagon receptor agonists.
- Potential medical use in treating disorders of the metabolic syndrome, including diabetes and obesity.
- May help with the reduction of excess food intake.
- Shows reduced activity on the GIP receptor, which may lower the risk of hypoglycemia.
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Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.0% | 929.06 | 10 MG
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HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide, immunogenic in cervical carcinomas. It is for research use only. Precursor T cells specific for the peptide are able to differentiate into HPV-specific effector cells. Peptide-loaded autologous dendritic cells can stimulate a specific cytotoxic CD8+ T-cell response.
- Specific T cells are expandable upon in vitro stimulation with peptide-pulsed dendritic cells.
- Response against K562 cells pulsed with the peptide was significantly blocked by anti-HLA class I Ab w6/32.
- Peptide in IVS culture shows specific T cell expansion.
- The peptide can induce cytotoxic T lymphocyte (CTL) responses if loaded on antigen presenting HLA class I molecules.
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Medchemexpress LLC Tertiapin-Q | 910044-56-3 | 99.8% | 2452.00 | 1 MG
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Tertiapin-Q is a highly selective blocker of G protein-coupled inwardly rectifying potassium (GIRK1/4) heterodimer and renal outer medullary potassium channel (ROMK1/Kir1.1). It also potently and selectively blocks Kir3.1-Kir3.4 channels and calcium activated large conductance potassium channels. Tertiapin-Q significantly prolongs the atrial effective refractory period in control and rapid atrial pacing rabbits, with a greater effect in the latter. Additionally, it acts as a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker.
- Highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1)
- Potently blocks Kir3.1-Kir3.4 channels and calcium activated large conductance potassium channels
- Prolongs atrial effective refractory period
- Acts as a muscarinic acetylcholine receptor-operated K+ current blocker
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Medchemexpress LLC HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG
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HPV16 E7 (86-93) (TFA) | 98.01% | 929.06 | 5 MG
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Medchemexpress LLC Insulin (human) | 11061-68-0 | 99.9% | 5807.57 | 200 MG
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Insulin (human) is a polypeptide hormone vital for regulating glucose levels in the body, primarily used in the treatment of diabetes mellitus. This product is a recombinant human insulin, a synthetic version of the hormone, and appears as a white to off-white solid. The human insulin gene contains specific intervening sequences, one within the 5'-untranslated segment of the mRNA and another interrupting the C-peptide encoding region, which are important for its biological function.
- Regulates glucose levels
- Used for diabetes mellitus treatment
- Recombinant human insulin
- White to off-white solid appearance
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Medchemexpress LLC SAAP 148 (TFA) | 99.55% | 3267.06 (free base) | 5 MG
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SAAP 148 TFA is a potent antimicrobial and antibiofilm agent designed for research applications. This compound demonstrates inhibitory efficacy against antibiotic-resistant pathogens. Its mechanism of action targets both planktonic bacteria and established biofilms.
- Antimicrobial action: Effectively combats a range of antibiotic-resistant bacteria.
- Antibiofilm properties: Inhibits the formation and disrupts existing bacterial biofilms.
- High purity: Exhibited at 99.55% purity, ensuring reliable experimental results.
- Research grade: Suitable for various in vitro and in vivo studies (for research use only).
- Broad spectrum efficacy: Active against a variety of pathogens with LC50 values ranging from 0.8 to 12.8 μM.
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Medchemexpress LLC Glucagon-like peptide-1 (GLP-1)(7-36), amide | 107444-51-9 | 99.9% | 3297.68 | 1 MG
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Glucagon-like peptide-1 (GLP-1)(7-36), amide is a physiological incretin hormone that stimulates insulin secretion. This peptide has a molecular weight of 3297.68 and appears as a white to off-white solid.
- Stimulates insulin secretion.
- Potent insulin-releasing peptide.
- Product of tissue-specific post-translational processing.
- Released postprandially from intestinal endocrine L cells.
- Normalizes fasting plasma glucose concentrations in Type 2 diabetic subjects (exogenous).
- Soluble in H2O at 100 mg/mL (30.32 mM; requires ultrasonic).
- For research use only.
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Medchemexpress LLC CINCHONIDINE 50G
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CINCHONIDINE 50G
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