Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC EMD638683 1181770-72-8 200mg
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EMD638683 (CAS 1181770-72-8) is a selective inhibitor of serum- and glucocorticoid-inducible kinases (SGKs) including isoforms SGK1 SGK2 and SGK3 SGK1 regulates key cellular processes such as ion transport survival proliferation and responses to steroid hormones EMD638683 shows inhibitory activity against SGK1 SGK2 and SGK3 (IC50 3 M) significantly reducing SGK-dependent phosphorylation of NDRG1 in vitro It demonstrates limited off-target interactions inhibiting only MSK1 and PRK2 at 1 M while sparing numerous other kinases In cell models EMD638683 influences mitochondrial polarization and caspase activity exhibiting antitumor effects in colorectal tumor cells and antihypertensive activity in vivo
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eMolecules 1255942-06-3 | DBCO-amine | Ambeed | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 50mg | 682930030
DBCO-amine | Ambeed | 1255942-06-3 | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 50mg | 682930030
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Medchemexpress LLC Leb-03-146 | 2858812-91-4 | 98.1% | C46H57N11O8 | 1 MG
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LEB-03-146 is a deubiquitinase-targeting chimera (DUBTAC) that links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a PEG2 linker. This compound is intended for research use only.
- Demonstrates significant WEE1 stabilization in HEP3B hepatoma cancer cells.
- Functions as a deubiquitinase-targeting chimera (DUBTAC).
- Links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000697392 77PD-Q 1MG
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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 1g
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Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials
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Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 98.97% | C37H48N6O10S3 | 50 MG
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Sulfo-Cy5 azide | 1782950-80-4 | 98.97% | C37H48N6O10S3 | 50 MG
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Cayman Chemical 4-HydroxyquInolIn 5g
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A quinoline alkaloid; is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules; has been used as a precursor in the synthesis of compounds with antibacterial activity; has been used as a fluorescent detection reagent for iron(III) in bovine liver samples
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Medchemexpress LLC 3,6,9,12,15,18-Hexaoxanonadecan-1-amine | 184357-46-8 | ≥97.0% | 10 G
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m-PEG6-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, while ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
- PEG-based PROTAC linker
- Cleavable ADC linker
- Used in the synthesis of PROTACs
- Used in the synthesis of antibody-drug conjugates (ADCs)
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Medchemexpress LLC m-PEG9-Amine | 211859-73-3 | >97.0% | 5 G
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m-PEG9-Amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs, and also functions as a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). It facilitates the construction of compounds that either selectively degrade target proteins via the ubiquitin-proteasome system or enable targeted delivery of cytotoxic drugs.
- Functions as a PEG-based PROTAC linker
- Suitable for the synthesis of PROTACs
- Acts as a cleavable ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Supports targeted protein degradation via the ubiquitin-proteasome system
- Enables targeted delivery of cytotoxic drugs
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TARGETMOL CHEMICALS INC Quinine dihydrochloride 500MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae). It is also an antimalarial and muscle relaxant (skeletal). Purity 99.45%
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TARGETMOL CHEMICALS INC Crisaborole 200MG
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Also available in 1 mL, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Crisaborole (AN-2728) is a phosphodiesterase 4 inhibitor. Purity 99.91%
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TARGETMOL CHEMICALS INC Insulin human 200MG
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients. Purity 99.99%
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TARGETMOL CHEMICALS INC Amikacin 200MG
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Also available in 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin. Purity 99.34%
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000770984 DBCO-AMINE TFA 10MG
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Medchemexpress LLC (S,R,S)-AHPC-CO-C9-acid (VH032-NH-CO-C9-acid) | 2172819-78-0 | 95.0% | 628.82 | 25 MG
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(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs. This product is for research use only and not validated for medical applications.
- E3 ligase ligand-linker conjugate
- Connects to ligand for protein to form PROTACs
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light and under nitrogen
- In solvent, store at -80°C for 6 months, or -20°C for 1 month, protected from light and under nitrogen
- Soluble in DMSO
- Soluble in various in vivo protocols
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