Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC LM11A-31 25mg | 102562-74-3 | 243.35 g/mol | C12H25N3O2 | 25 MG
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LM11A-31 a non-peptide p75NTR (neurotrophin receptor p75) modulator is an orally active and potent proNGF (nerve growth factor) antagonist LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer s disease mouse models with mid- to late-stage disease progression[1][2]
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Cayman Chemical PropIdIum IodIde 50mg
A fluorescent probe commonly used to identify dead cells; excitation at 488-535 nm and emission maximum of 617 nm
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Chemscene ChemScene | 7-Aminoquinoline-2-carboxylic acid | 250MG | CS-0376828 | 0.98 | 106139-28-0| MFCD18816931 | 188.19
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ChemScene | 7-Aminoquinoline-2-carboxylic acid | 250MG | CS-0376828 | 0.98 | 106139-28-0| MFCD18816931 | 188.19
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Apexbio Technology LLC Quinine HCl Dihydrate 6119-47-7 10mM (in 1mL DMSO)
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Quinine HCl Dihydrate is a quinoline alkaloid hydrochloride salt presented as a dihydrate form It exerts its biological activity primarily through interference with heme detoxification mechanisms within Plasmodium species disrupting parasite-mediated heme metabolism and inducing cytotoxic free heme accumulation At the molecular level quinoline derivatives may inhibit nucleic acid synthesis affecting DNA replication and transcription events during erythrocytic lifecycle stages Researchers frequently utilize Quinine HCl Dihydrate for studies on antimalarial drug mechanisms parasite resistance pathways and as a reference standard in pharmacological and pharmacokinetic assessments
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Apexbio Technology LLC Carboxine 5234-68-4 200mg
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Carboxine (5234-68-4) is a small-molecule inhibitor targeting mitochondrial succinate dehydrogenase (SDH) It is designed to inhibit SDH activity thereby interfering with fungal cellular respiration pathways Carboxine exerts its biological activity primarily through inhibition of mitochondrial SDH In in vitro studies Carboxine demonstrates inhibitory efficacy with IC50 values typically in a micromolar range depending on fungal species and assay conditions Based on these pharmacological properties Carboxine holds research potential in studying mitochondrial metabolism energy production pathways fungicidal resistance mechanisms and assessment of biochemical impacts of SDH inhibition within fungal cells
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Apexbio Technology LLC Artemisinine 63968-64-9 200mg
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Artemisinine (CAS 63968-64-9) is a sesquiterpene lactone designed to modulate parasite cell integrity and cancer cell viability Artemisinine exerts its biological activity primarily through interaction with parasite-derived heme groups leading to the formation of reactive oxygen species that disrupt cell integrity and by inducing oxidative stress and apoptotic pathways in tumor cells In in vitro studies Artemisinine demonstrates cytotoxicity toward cancer cells and antimalarial activity with reported IC50 values ranging from 5 to 20 M depending on experimental conditions cell or parasite lines utilized Based on these pharmacological properties Artemisinine holds research potential in antimalarial and antitumor applications
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Medchemexpress LLC Imiquimod Maleate 10Mmx1Ml Sol | HY-B0180B-10MMX1ML
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Imiquimod Maleate 10Mmx1Ml Sol
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eMolecules Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 250mg 272386941 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 250mg 272386941 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
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Apexbio Technology LLC Mycophenolate Mofetil 128794-94-5 200mg
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Mycophenolate Mofetil (128794-94-5) is a small-molecule inhibitor targeting inosine monophosphate dehydrogenase (IMPDH) isoforms I and II It is designed to selectively and reversibly inhibit IMPDH thereby disrupting de novo guanosine nucleotide biosynthesis Mycophenolate Mofetil exerts its biological activity primarily through non-competitive inhibition of IMPDH blocking the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) In in vitro studies Mycophenolate Mofetil demonstrates inhibitory activity with IC50 values of 39 nM and 27 nM for IMPDH I and II respectively Based on these pharmacological properties Mycophenolate Mofetil holds research potential in studies on immunology purine metabolism regulation cell proliferation transplant rejection and autoimmune disease models
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Medchemexpress LLC Navitoclax (ABT-263) | 923564-51-6 | MFCD12756219 | ≥98.0% | 974.61 g·mol⁻¹ | C47H55ClF3N5O6S3 | 200 MG
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Navitoclax (ABT-263) is a potent, orally active small-molecule inhibitor of anti-apoptotic Bcl-2 family proteins used in preclinical apoptosis and oncology research. Supplied as a powder, it is used for both in vitro assays and in vivo models, with documented solubility and recommended storage for stability.
- Potent Bcl-2 family inhibitor for apoptosis research.
- Orally active small molecule suitable for in vivo studies.
- High solubility in DMSO for convenient stock solutions.
- Available in multiple quantities for dosing flexibility.
- Recommended storage conditions to preserve stability.
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Medchemexpress LLC Mebendazole-amine 5mg | 52329-60-9 | 237.26 g/mol | C14H11N3O | 5 MG
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Mebendazole-amine is a research metabolite of mebendazole supplied as a high-purity solid for analytical and metabolic studies. Store protected from light and follow solvent storage recommendations for long-term stability.
- Research metabolite of mebendazole.
- High purity: 98.35%.
- Molecular weight 237.26 g/mol; formula C14H11N3O.
- Supplied in small vials suitable for analytical work (e.g., 5 mg).
- Appearance: solid, white to off-white.
- Storage: 4°C, protect from light; in solvent, -80°C up to 6 months or -20°C up to 1 month.
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TARGETMOL CHEMICALS INC Aprepitant 200MG
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Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Aprepitant is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer. Purity 99.9%
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TARGETMOL CHEMICALS INC Monocrotaline 200MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Monocrotaline (Crotaline) is a pyrrolizidine alkaloid extracted from the seeds of the Crotalaria plant. Monocrotaline has certain cellular activity against HepG2 cells and can induce pulmonary hypertension in rodents. Purity 99.59%
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TARGETMOL CHEMICALS INC L-Sodium lactate 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (L)-Sodium lactate (Sodium L-Lactate) is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids. Purity 99.17%
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TARGETMOL CHEMICALS INC Isomaltose 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Isomaltose (D-Isomaltose) is a reducing disaccharide, similar to maltose, but with an alpha-(1-6)-linkage instead of the alpha-(1-4)-linkage. Purity 98.27%
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