Quinolines and derivatives
Cambridge Isotope Laboratories 1 2 3 9-TetraCDD (unlabeled) 25 ng/mL in nonane 0 2 mL
1 2 3 9-TetraCDD (unlabeled) 25 ng/mL in nonane 0 2 mL
Apexbio Technology LLC Regorafenib 755037-03-7 200mg
Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research
Apexbio Technology LLC LY2940680 1258861-20-9 200mg
LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations
Apexbio Technology LLC Resiquimod (R-848) 144875-48-9 10mM (in 1mL DMSO)
Resiquimod (R-848) is an immunomodulatory small molecule structurally related to imiquimod It functions primarily by activating immune responses via inducing cytokine release In vitro studies with human peripheral blood mononuclear cells (PBMC) indicate that Resiquimod promotes dose-dependent production of cytokines including interferon-alpha (IFN- ) tumor necrosis factor (TNF) interleukin-1 (IL-1 ) and interleukin-6 (IL-6) Mechanistically Resiquimod increases intracellular IL-1 levels and both monocytes and B-cells respond by secreting IFN upon stimulation In addition it elevates mRNA expression of IFN- TNF and IL-8 in treated PBMC relative to untreated controls Resiquimod demonstrates antiviral and antitumor activities in preclinical animal models frequently utilized as an immune response potentiator and Toll-like receptor (TLR) agonist in biomedical investigations (IC50 values typically range in low micromolar)
Apexbio Technology LLC GDC-0941 957054-30-7 200mg
GDC-0941 (CAS 957054-30-7) is a selective small-molecule inhibitor of class I phosphoinositide 3-kinase (PI3K) a critical component involved in the PI3K/Akt signaling pathway frequently dysregulated in cancer By competitively binding to the ATP-binding site of PI3K GDC-0941 inhibits generation of the downstream signaling molecule phosphatidylinositol-3 4 5-trisphosphate (PIP3) Exhibiting high selectivity against p110 / (IC50 approx 3 nM) and moderate selectivity for p110 (33 nM) and p110 (75 nM) GDC-0941 has demonstrated antiproliferative activity across diverse tumor cell lines in vitro (e g A2780 PC3 U87MG) and tumor growth inhibition in xenograft cancer models supporting its utility in cancer research
Apexbio Technology LLC Tetracycline(Synonyms: Achromycin, Sumycin, Tetracyn, Tetrex, Panmycin, Robitet, Polycycline, Cyclopar), 200mg, CAS: 60-54-8.
Tetracycline (CAS 60-54-8) is a broad-spectrum polyketide antibiotic originally isolated from Streptomyces species It functions primarily through reversible binding to the bacterial 30S ribosomal subunit disrupting the interaction of aminoacyl-tRNA with the ribosomal acceptor site and thereby inhibiting bacterial protein synthesis Additionally tetracycline interacts partially with the 50S ribosomal subunit and may compromise bacterial membrane integrity causing leakage of intracellular components Tetracycline remains widely employed in microbiological research as an antibiotic selection marker and a tool for investigating ribosomal functions
Apexbio Technology LLC Q-VD(OMe)-OPh 10mg
Q-VD(OMe)-OPh is a pan-caspase inhibitor structurally identified as quinolyl-valyl-O-methylaspartyl-[2 6-difluorophenoxy]-methyl ketone As a broad-spectrum inhibitor Q-VD(OMe)-OPh reversibly targets multiple caspases involved in apoptotic signaling including initiator caspases (such as caspases 8 9 10 and 12) and executioner caspases (such as caspase 3) thereby blocking intrinsic extrinsic and endoplasmic reticulum-mediated apoptotic pathways In recombinant enzyme assays this inhibitor displays nanomolar-range IC values against caspases 1 3 8 and 9 Due to minimal cytotoxicity at tested concentrations Q-VD(OMe)-OPh serves as a tool compound in apoptosis-related biomedical research applied broadly for dissecting caspase-dependent apoptotic mechanisms and evaluating cytoprotective strategies
Apexbio Technology LLC BMH-21(Synonyms: BMH21, BMH 21, CID 46835406, RNA polymerase I inhibitor BMH-21, RNA Pol I inhibitor BMH-21), 200mg, CAS: 896705-16-1.
BMH-21 (CAS 896705-16-1) is a planar heterocyclic small molecule DNA intercalator that selectively inhibits RNA polymerase I (Pol I)-mediated transcription It preferentially inserts into GC-rich double-stranded DNA regions leading to Pol I blockade and subsequent degradation of its catalytic subunit RPA194 BMH-21 exhibits cytotoxic activity across various human cancer cell lines independently of the p53 status disrupting nucleolar integrity and RNA synthesis Furthermore BMH-21 promotes p53 expression in epithelial compartments of human prostate tissues demonstrating tissue permeability and highlighting its applicability in anticancer research
Apexbio Technology LLC Batimastat (BB-94)(Synonyms: BB-94, Batimastat, MMP inhibitor BB-94), 25mg, CAS: 130370-60-4.
Batimastat (BB-94 CAS 130370-60-4) is a synthetic small-molecule inhibitor targeting matrix metalloproteinases (MMPs) Structurally a polypeptide-like analogue of collagen substrates batimastat contains a peptidic backbone and a hydroxamate moiety that binds the catalytic zinc atom of MMPs It inhibits several MMP subtypes markedly including MMP-1 MMP-2 MMP-3 MMP-7 and MMP-9 with reported IC50 values of 3 4 20 6 and 4 nM respectively In preclinical studies batimastat demonstrates inhibitory effects on tumor growth and angiogenesis across various tumor models including ovarian and colon carcinoma xenografts making it relevant for cancer research and therapeutic development
Chemscene ChemScene | 8-Bromo-5-nitroquinoline | 5G | CS-0035507 | 0.98 | 139366-35-1| MFCD00509069 | 253.055
ChemScene | 8-Bromo-5-nitroquinoline | 5G | CS-0035507 | 0.98 | 139366-35-1| MFCD00509069 | 253.055
Selleck Chemical LLC SH-4-54
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5 respectively
Selleck Chemical LLC SH-4-54
SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5 respectively
Apexbio Technology LLC Difloxacin HCl 91296-86-5 1g
Difloxacin HCl (CAS 91296-86-5) is a small-molecule inhibitor targeting DNA gyrase and topoisomerase IV It is designed to interfere with DNA gyrase-mediated DNA synthesis thereby inhibiting bacterial DNA replication and cell division Difloxacin HCl exerts its biological activity primarily through inhibition of DNA gyrase and topoisomerase IV In cultured human neuroblastoma cells exhibiting multidrug resistance associated protein (MRP)-mediated chemoresistance difloxacin HCl (50 g/ml) increases cell sensitivity to MRP substrates including doxorubicin vincristine daunorubicin and potassium antimony tartrate indicating reversal of the drug-resistance phenotype Based on these pharmacological properties difloxacin HCl holds research potential in antimicrobial susceptibility testing and studies of multidrug resistance reversal
Selleck Chemical LLC Chelerythrine Chloride (NSC 646662) S1292-5mg
Chelerythrine Chloride (NSC 646662 Broussonpapyrine) is a potent selective antagonist of PKC with IC50 of 0 66 M