Quinolines and derivatives

TARGETMOL CHEMICALS INC Rosiglitazone 200MG

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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Rosiglitazone (BRL49653) is a PPARgamma agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. Purity 99.87%

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Medchemexpress LLC Ag490 (Tyrphostin AG490) | 133550-30-8 | 99.9% | 200 MG

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AG490 (Tyrphostin AG490) is a small-molecule tyrosine kinase inhibitor that targets JAK2, JAK3, and EGFR, blocking downstream STAT activation. It is supplied for research use and is available as a solid and as DMSO solution for in vitro biochemical and cell-based assays.

• Inhibits JAK2/3 and EGFR-mediated STAT signaling.
• Suitable for in vitro kinase inhibition and cell signaling studies.
• High analytical purity reported at 99.86%.
• Available as a solid and as a DMSO solution for assay preparation.
• CAS number 133550-30-8 supports unambiguous identification.

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Apexbio Technology LLC Apixaban 503612-47-3 200mg

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Apixaban (CAS 503612-47-3) is a highly selective reversible inhibitor of coagulation Factor Xa with Ki values of 0 08 nM and 0 17 nM for human and rabbit enzymes respectively By targeting Factor Xa a central serine protease in the coagulation cascade apixaban effectively impedes thrombin generation and subsequent clot formation In vitro apixaban prolongs coagulation parameters in human plasma at submicromolar concentrations and demonstrates potent antithrombotic activity across multiple animal models With favorable pharmacokinetics including high oral bioavailability and low clearance in preclinical studies apixaban serves as a valuable tool for investigating coagulation mechanisms and evaluating anticoagulant strategies

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TARGETMOL CHEMICALS INC Zorifertinib 200MG

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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor. The IC50 values were 0.2, 0.3 and 0.2 nM for EGFR L858R mutant, TK wild-type, and Exon 19Del enzymes, respectively. Purity 99.36%

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Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG

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Apilimod is a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is also described as a potent and highly selective PIKfyve inhibitor.

• Potent IL-12/IL-23 inhibitor
• Strongly inhibits IL-12 with IC50s of 1 nM and 2 nM
• Potent and highly selective PIKfyve inhibitor
• Inhibits IFN-γ production in human PBMCs
• Reduces severity of experimental autoimmune uveoretinitis (EAU)
• Lowers level of IL-12 p40 in serum without altering body weight in EAU mice
• Effective in Th1 model, with 51%±8% inhibition

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Apexbio Technology LLC Tideglusib 865854-05-3 200mg

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Tideglusib is a potent selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) functioning through irreversible and ATP-noncompetitive inhibition with reported IC50 of 60 nM Mechanistically Tideglusib binds in a manner independent of ATP leading to sustained enzyme inactivation Preclinical studies utilizing animal models demonstrate Tideglusib s ability to attenuate hyperphosphorylation of Tau protein reduce amyloid plaque accumulation prevent neuronal loss and enhance cognitive performance Currently undergoing clinical investigation Tideglusib has advanced through Phase II studies for Alzheimer s disease (AD) and progressive supranuclear palsy (PSP) exploring therapeutic applicability related to its GSK-3 inhibition activity

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Medchemexpress LLC Zorifertinib | 1626387-80-1 | 99.4% | 459.90 | 200MG

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Zorifertinib (AZD3759) is a potent, orally active, and BBB-penetrant EGFR inhibitor. Its IC50s are 0.3, 0.2, and 0.2 nM for EGFR wt, EGFR L858R, and EGFR exon 19Del, respectively, at Km ATP concentrations. This compound induces cancer cell apoptosis and exhibits antitumor activity, making it suitable for research in NSCLC, HCC, and similar conditions.

• Potent EGFR inhibitor
• Orally active
• BBB-penetrant
• Induces cancer cell apoptosis
• Exhibits antitumor activity
• Applicable for NSCLC, HCC, and other research areas

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Apexbio Technology LLC Kobe0065 436133-68-5 200mg

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Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms

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Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.47% | 257.30 | 100 MG

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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• Utilized in the synthesis of PROTACs
• Contains two distinct ligands connected by a linker
• Exploits intracellular ubiquitin-proteasome system
• Selectively degrades target proteins