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Filtered Search Results
Medchemexpress LLC 2,8-Quinolinediol | 15450-76-7 | MFCD00216696 | 99.89% | 161.16 | 5 G
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8-Hydroxy-2(1H)-quinolinone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
- It functions as a biochemical reagent.
- Can be utilized as a biological material for life science research.
- Can be utilized as an organic compound for life science research.
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Cayman Chemical 4-HydroxyquInolIn 25g
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A quinoline alkaloid; is a core component of alkyl-4-hydroxyquinoline quorum sensing molecules; has been used as a precursor in the synthesis of compounds with antibacterial activity; has been used as a fluorescent detection reagent for iron(III) in bovine liver samples
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000403372 ENDO CNTINH-03 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000771329 4-PIPERIDYL N-2-BIP 10G
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Apexbio Technology LLC RO4929097(Synonyms: RO-4929097, RO 4929097, Gamma-Secretase Inhibitor RO4929097, RO4929097 γ-secretase inhibitor), 200mg, CAS: 847925-91-1.
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RO4929097 (CAS 847925-91-1) is a potent selective small-molecule inhibitor of -secretase an essential protease in the Notch signaling pathway It inhibits -secretase with high specificity (IC50 4 nM EC50 5 nM) showing minimal inhibitory activity against closely related proteases and over 100-fold selectivity versus a broad spectrum of other proteases By preventing Notch receptor cleavage and subsequent signaling activation RO4929097 suppresses proliferation and tumorigenesis across various tumor models including melanoma breast colorectal pancreatic and lung cancers Clinical studies have assessed RO4929097 alone or combined with other anticancer agents for advanced solid tumors
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Apexbio Technology LLC Ganetespib (STA-9090)(Synonyms: STA-9090, Ganetespib, STA9090, STA 9090), 200mg, CAS: 888216-25-9.
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Ganetespib (STA-9090 CAS 888216-25-9) is a small-molecule inhibitor targeting heat shock protein 90 (Hsp90) It binds competitively to the ATP-binding pocket located at the N-terminal region of Hsp90 disrupting its chaperone activity and subsequently causing degradation of client proteins involved in tumor growth and survival Structurally distinct from geldanamycin-derived inhibitors Ganetespib features a triazolone moiety Preclinical studies have demonstrated antitumor activity across various cancer cell types including lung prostate colon breast cancers melanoma and leukemia highlighting its therapeutic potential for cancer research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000771391 2 5 -DIMETHOXY-1 1 1G
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Apexbio Technology LLC ML385(Synonyms: ML-385, NRF2 inhibitor ML385, ML385 NRF2 inhibitor, ML385 inhibitor, NRF2-IN-1, NRF2-IN1), 200mg, CAS: 846557-71-9.
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ML385 (CAS 846557-71-9) is a selective inhibitor of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) displaying an IC50 of 1 9 M NRF2 regulates cellular antioxidant responses detoxification pathways and multidrug transporters and its activation is frequently implicated in therapeutic resistance of non-small cell lung cancer (NSCLC) In A549 cells ML385 treatment reduces expression of NRF2-dependent genes dose- and time-dependently Additionally in NSCLC mouse models ML385 treatment diminished tumor growth and metastasis especially when combined with carboplatin underscoring its utility in cancer research and potential therapeutic exploration
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=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 10mg | 552750157](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000493285.jpg-250.jpg)
eMolecules 103476-89-7 | Leupeptin hemisulfate | Ambeed | MFCD00037012 | 951.200 | C40H78N12O12S | 97.000 | OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 10mg | 552750157
Leupeptin hemisulfate | Ambeed | 103476-89-7 | MFCD00037012 | 951.200 | C40H78N12O12S | 97.000 | OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 10mg | 552750157
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=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 50mg | 552750159](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000493283.jpg-250.jpg)
eMolecules 103476-89-7 | Leupeptin hemisulfate | Ambeed | MFCD00037012 | 951.200 | C40H78N12O12S | 97.000 | OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 50mg | 552750159
Leupeptin hemisulfate | Ambeed | 103476-89-7 | MFCD00037012 | 951.200 | C40H78N12O12S | 97.000 | OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 50mg | 552750159
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![Medchemexpress LLC Naphtho[1,2-d]thiazol-2-ylamine | 40172-65-4 | MFCD00051329 | 99.7% | 200.27 | C11H8N2S | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000264707.png-250.jpg)
Medchemexpress LLC Naphtho[1,2-d]thiazol-2-ylamine | 40172-65-4 | MFCD00051329 | 99.7% | 200.27 | C11H8N2S | 5 MG
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SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine, CAS 40172-65-4) is a research-grade small-molecule activator of calcium-activated potassium channels (KCa2/KCa3.1), used to probe ion channel function and endothelial or neuronal hyperpolarization in vitro and in vivo studies.
- Potent channel activator with KCa3.1 EC50 ~260 nM and KCa2 subtype EC50s in the low micromolar range.
- High purity for research use (≈99.7%).
- Small molecular weight and defined composition: 200.27 g/mol; formula C11H8N2S.
- Soluble in DMSO (≈125 mg/mL) and formulatable for in vivo dosing.
- Supplied as a solid powder suitable for biochemical and cellular assays.
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Apexbio Technology LLC LY2886721 1262036-50-9 200mg
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LY2886721 (CAS 1262036-50-9) is an orally bioavailable inhibitor of -site amyloid precursor protein cleaving enzyme 1 (BACE1) an aspartyl protease integral to amyloid precursor protein (APP) cleavage and amyloid- (A ) generation LY2886721 inhibits BACE1 activity with an IC50 of approximately 20 3 nM effectively reducing soluble APP and elevating soluble APP in human cell models (HEK293Swe) and neuronal cultures (PDAPP) at IC50 values of 18 7 nM and 10 7 nM respectively In animal models such as PDAPP mice oral LY2886721 administration dose-dependently reduces cerebral A C99 and sAPP levels Due to its BACE1 inhibitory action LY2886721 serves as a valuable tool in Alzheimer s disease research and therapeutic development
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Apexbio Technology LLC Bepotastine Besilate 190786-44-8 200mg
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Bepotastine Besilate (CAS number 190786-44-8) is a small molecule antagonist targeting the histamine H1 receptor By binding selectively to this receptor subtype Bepotastine attenuates histamine-induced cellular responses decreasing symptoms associated with allergic reactions In experimental settings it serves as a pharmacological tool to investigate histamine-related inflammatory pathways and receptor signaling mechanisms Its utility extends to studies of allergic responses inflammation modulation and histamine receptor pharmacodynamics in biomedical research
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Apexbio Technology LLC Mefloquine hydrochloride 51773-92-3 10mM (in 1mL DMSO)
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Mefloquine hydrochloride is a quinoline-based antimalarial compound structurally related to quinidine with demonstrated inhibitory effects on Plasmodium falciparum It functions primarily through modulation of potassium ion channels displaying an IC50 around 1 M against KvLQT1/minK channel currents and approximately 5 6 M against HERG channel currents Research indicates that mefloquine induces cellular oxidative stress modulating intracellular signaling pathways including Akt phosphorylation ERK JNK and AMPK in vitro Current studies also explore its potential cytotoxic activity toward cancer cell lines and evaluate effectiveness against urinary schistosomiasis in phase 2 clinical trials
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000569650 S-INDOXIMOD-200MG
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