Quinolines and derivatives
Medchemexpress LLC Deferoxamine mesylate (Standard) | 138-14-7 | 99.47% | 100 MG
Deferoxamine mesylate (Standard) is the analytical standard for Deferoxamine mesylate, intended for research and analytical applications. It is an iron chelator, binding to Fe(III) and other metal cations, and is widely used to reduce iron accumulation and deposition in tissues. It also upregulates HIF-1α levels with good antioxidant activity, shows anti-proliferative activity, and can induce apoptosis and autophagy in cancer cells. This compound can be used in studies related to diabetes, neurodegenerative diseases, anti-cancer research, and anti-COVID-19 research.
- The compound is an analytical standard, serving as a reference standard for assays.
- Commonly employed in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
Medchemexpress LLC 8-Hydroxyquinoline (8-Quinolinol) | 148-24-3 | 100.0% | 500 MG
8-Hydroxyquinoline (8-Quinolinol) | 148-24-3 | 100.0% | 500 MG
Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | MFCD00012656 | 99.9% | 500 MG
Trifluoperazine dihydrochloride is an antipsychotic agent that functions by blocking central dopamine receptors. It is also a potent α1-adrenergic receptor antagonist and a potent NUPR1 inhibitor, exhibiting anticancer activity. Additionally, it acts as a calmodulin inhibitor and inhibits P-glycoprotein. This compound can be used in schizophrenia research and is a reversible inhibitor of influenza virus morphogenesis.
- Antipsychotic agent
- Blocks central dopamine receptors
- Potent α1-adrenergic receptor antagonist
- Potent NUPR1 inhibitor
- Exerts anticancer activity
- Calmodulin inhibitor
- Inhibits P-glycoprotein
- Used for schizophrenia research
- Reversible inhibitor of influenza virus morphogenesis
Medchemexpress LLC Ranolazine | 95635-55-5 | 99.8% | 200 MG
Ranolazine (CVT 303) is an anti-angina drug that inhibits the late phase of inward sodium current (INa and IKr) and acts as an antianginal agent. It is also a partial fatty acid oxidation (FAO) inhibitor. This product is for research use only and not sold to patients.
- Inhibits late phase of inward sodium current (INa and IKr)
- Acts as an antianginal agent
- Partial fatty acid oxidation (FAO) inhibitor
- Does not affect heart rate or blood pressure
Medchemexpress LLC Trifluoperazine dihydrochloride | 440-17-5 | 99.9% | 100 MG
Trifluoperazine dihydrochloride is a potent antipsychotic agent that functions by blocking central dopamine receptors. This compound also acts as a strong α1-adrenergic receptor antagonist and a NUPR1 inhibitor, demonstrating anticancer activity. Additionally, it is a calmodulin inhibitor and can inhibit P-glycoprotein. Trifluoperazine dihydrochloride is suitable for research related to schizophrenia and has been shown to be a reversible inhibitor of influenza virus morphogenesis.
- Potent antipsychotic agent
- Blocks central dopamine receptors
- Strong α1-adrenergic receptor antagonist
- NUPR1 inhibitor with anticancer activity
- Calmodulin inhibitor
- Inhibits P-glycoprotein
- Suitable for schizophrenia research
- Reversible inhibitor of influenza virus morphogenesis
- IC50 of 16 μM for cytotoxicity in HL-60 cells by MTT assay
Apexbio Technology LLC Carboplatin 41575-94-4 200mg
Carboplatin (CAS 41575-94-4) is a small molecule inhibitor of DNA synthesis It exerts its antiproliferative activity by binding to DNA thereby hindering DNA synthesis and impairing DNA repair pathways In cell proliferation assays carboplatin inhibits growth of human ovarian carcinoma cell lines A2780 SKOV-3 IGROV-1 and HX62 with IC50 values of 6 2 12 4 2 2 and 116 M respectively Carboplatin shows antiproliferative effects on lung cancer cell lines UMC-11 H727 and H835 and demonstrates antitumor activity in xenograft mouse models Carboplatin is commonly used in preclinical oncology research
Medchemexpress LLC Argatroban monohydrate | 141396-28-3 | MFCD23102419 | 99.6% | 1 ML
Argatroban monohydrate is a direct, selective thrombin inhibitor. It may also have a complementary effect for preventing thrombus formation without aggravating bleeding tendency due to its monotarget specificity to thrombin.
- Administration (0.5 to 2 micrograms/kg/min) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries.
- Appears to enhance reperfusion with TPA in patients with AMI, particularly in those with delayed presentation, and was associated with lower incidences of major bleeding and adverse clinical outcomes compared to heparin.
- Suitable for creating animal models for thrombolysis.
Medchemexpress LLC Imiquimod maleate | 896106-16-4 | 99.9% | 100 MG
Imiquimod maleate is an immune response modifier and a selective toll-like receptor 7 (TLR7) agonist. It demonstrates antiviral and antitumor effects in vivo and is used in research for external genital and perianal warts, cancer, and COVID-19. It appears as a white to off-white solid.
- Molecular weight: 356.38
- Formula: C18H20N4O4
- Ships at room temperature in continental US
- Store at 4°C, sealed, away from moisture
- When in solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO (25 mg/mL) and H2O (2 mg/mL)
- Targets TLR7 and HSV-1
- Used to induce psoriasis models
![Apexbio Technology LLC [Ser25] Protein Kinase C (19-31) 136795-05-6 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000063814.png-250.jpg)
Apexbio Technology LLC [Ser25] Protein Kinase C (19-31) 136795-05-6 5mg
[Ser25] Protein Kinase C (19-31) (CAS 136795-05-6) is an oligopeptide derived from the pseudosubstrate regulatory domain (amino acids 19-31) of Protein Kinase C alpha (PKC ) modified by substitution of alanine with serine at residue 25 Its sequence is Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val with a molecular weight of 1559 82 and molecular formula C67H118N26O17 It acts as a PKC substrate peptide enabling in vitro measurement of kinase enzymatic activity via serine phosphorylation PKC enzymes participate in diverse cellular processes including adhesion transformation cell cycle control and calcium signaling making this peptide an important tool for kinase activity studies and intracellular signaling research
![Apexbio Technology LLC [Ser25] Protein Kinase C (19-31) 136795-05-6 25mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000063685.png-250.jpg)
Apexbio Technology LLC [Ser25] Protein Kinase C (19-31) 136795-05-6 25mg
[Ser25] Protein Kinase C (19-31) (CAS 136795-05-6) is an oligopeptide derived from the pseudosubstrate regulatory domain (amino acids 19-31) of Protein Kinase C alpha (PKC ) modified by substitution of alanine with serine at residue 25 Its sequence is Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val with a molecular weight of 1559 82 and molecular formula C67H118N26O17 It acts as a PKC substrate peptide enabling in vitro measurement of kinase enzymatic activity via serine phosphorylation PKC enzymes participate in diverse cellular processes including adhesion transformation cell cycle control and calcium signaling making this peptide an important tool for kinase activity studies and intracellular signaling research
Apexbio Technology LLC AMG-900 945595-80-2 200mg
AMG-900 (CAS 945595-80-2) is a small-molecule inhibitor targeting Aurora kinases a group of serine/threonine kinases crucial for mitosis regulation It exhibits potent ATP-competitive inhibitory activity against all three Aurora kinase isoforms resulting in suppression of Aurora-A and Aurora-B autophosphorylation events AMG-900 induces disruption of cellular mitotic processes leading to cell cycle arrest and subsequent apoptotic cell death Preclinically AMG-900 demonstrates activity across multiple tumor cell lines including multidrug-resistant and taxane-resistant variants and inhibits tumor growth in mouse xenograft models suggesting utility for cancer research
Apexbio Technology LLC Bindarit 130641-38-2 200mg
Bindarit (CAS 130641-38-2) also known as AF-2838 is a synthetic small-molecule inhibitor targeting the CC chemokines MCP-1 (CCL2) MCP-2 (CCL8) and MCP-3 (CCL7) By suppressing the transcription and production of MCP proteins Bindarit reduces monocyte chemoattraction and inflammation In vitro data indicate that Bindarit inhibits LPS-induced MCP-1 synthesis in monocytes with an IC50 around 172 M and selectively decreases MCP expression without impacting unrelated cytokines such as IL-6 or IL-8 Animal studies demonstrate its potential to reduce inflammatory cell infiltration vascular smooth muscle cell proliferation and neointimal hyperplasia in rodent injury models highlighting its value for inflammation and cardiovascular disease research