Quinolines and derivatives
Medchemexpress LLC Recombinant rat B7-H2 (ICOS ligand) protein, His tag | 100 UG
Recombinant rat B7-H2 (ICOS ligand) protein expressed in HEK293 cells with a C-terminal His tag. Supplied as a purified recombinant protein for research use, it is suitable for biochemical assays, receptor binding studies, and assay development involving the ICOS pathway. Refer to the supplier datasheet for formulation, purity, and storage instructions.
- Suitable for biochemical assays, ELISA, and receptor binding studies.
- Expressed in mammalian cells to preserve native folding and glycosylation.
- C-terminal His tag facilitates purification and detection.
- Provided as purified protein; check the datasheet for formulation and endotoxin level.
- Intended for research use only, not for clinical or diagnostic applications.
Apexbio Technology LLC Lonafarnib 193275-84-2 200mg
Lonafarnib (CAS 193275-84-2) also known as SCH66336 or Sarasar is a tricyclic orally bioavailable inhibitor of farnesyltransferase (FTase) functioning without peptide or sulfhydryl groups FTase mediates post-translational farnesylation of Ras proteins a modification required for their membrane localization and activation of downstream signaling pathways involved in cellular growth proliferation and survival By inhibiting this enzymatic activity Lonafarnib disrupts Ras translocation to the plasma membrane limiting Ras-mediated signaling Currently Lonafarnib is widely evaluated in preclinical and clinical investigations particularly in oncology contexts
![Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243212.png-250.jpg)
Medchemexpress LLC N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide | 303162-79-0 | MFCD17012805 | 99.8% | 399.51 g/mol | C24H21N3OS | 200 MG
TAK-715 is an orally active, potent p38 MAPK inhibitor used in research to probe p38α signaling and related pathways; it also inhibits casein kinase I (CK1δ/ε) and has demonstrated efficacy in preclinical inflammation models.
- Potent p38α inhibition (IC50 7.1 nM) with reduced activity against p38β (IC50 200 nM).
- Reported inhibition of CK1δ/ε and modulation of Wnt/β-catenin signaling.
- Chemical formula C24H21N3OS; molecular weight 399.51 g/mol.
- High reported purity (99.76%).
- Soluble in DMSO (≈50 mg/mL) with suggested protocols for in vivo formulation.
- Powder stable at -20°C for extended storage; solvent stocks stable at -80°C.
Medchemexpress LLC L-azidonorleucine (hydrochloride) | 1454334-76-9 | 98.0% | 200 MG
L-Azidonorleucine hydrochloride is an unnatural amino acid that serves as a methionine surrogate. It is used to label mammalian cell proteins and identify various methionyl-tRNA synthetase (MetRS) mutants. This compound functions as a click chemistry reagent due to its azide group, which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Unnatural amino acid and methionine surrogate
- Labels mammalian cell proteins
- Identifies methionyl-tRNA synthetase (MetRS) mutants
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Panobinostat | 404950-80-7 | MFCD09833242 | 99.4% | 349.43 | C21H23N3O2 | 200 MG
Panobinostat is a potent, orally active, non-selective histone deacetylase (HDAC) inhibitor supplied as a research-grade powder for laboratory use. It exhibits antineoplastic activity and is commonly used in epigenetic and cancer research, and in studies of apoptosis and autophagy. Not for human or veterinary use.
- Potent non-selective HDAC inhibitor with antineoplastic activity.
- High purity (99.4% by LCMS).
- Powder form, soluble in DMSO ≥ 100 mg/mL.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (1 year).
- Used in studies of apoptosis, autophagy, and cancer cell proliferation.
- Intended for research use only; not for human or veterinary use.
Medchemexpress LLC Sulfo-Cy5.5 azide | 1955527-41-9 | MFCD28334525 | ≥95.0% | 999.16 | C44H50N6O13S4 | 10 MG
Sulfo-Cy5.5 Azide is a water-soluble, far-red fluorescent click-chemistry reagent containing an azide functional group for covalent labeling of peptides, proteins, and oligonucleotides. It is suitable for imaging applications and reacts via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC); excitation is ~673 nm with emission ~707 nm.
- Water-soluble fluorescent dye suitable for aqueous labeling reactions.
- Azide functional group enables CuAAC and SPAAC click chemistries.
- Far-red emission for reduced background and deep-tissue imaging.
- High purity (≥95.0%) for reliable labeling results.
- Soluble in DMSO at 50 mg/mL with gentle warming and sonication.
- Store protected from light; in solvent store at -80°C for long term.
Medchemexpress LLC DOTMA | 104872-42-6 | 99.91% | 670.57 | 200 MG
DOTMA is a cationic lipid used as a non-viral vector for gene therapy. It is a component of liposomes for encapsulating siRNA, microRNA, and oligonucleotides, and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. It has demonstrated good gene transfection effects both in vitro and in vivo.
- Cationic lipid
- Non-viral vector for gene therapy
- Component of liposomes for encapsulating siRNA, microRNA, and oligonucleotides
- Used for in vitro gene transfection
- Promotes effective interaction between liposomes and cell membranes
- Induces positive charge on liposomes
- Good gene transfection effects both in vitro and in vivo
- High intravenous transfection activity in CD-1 mouse
Apexbio Technology LLC Tasquinimod 254964-60-8 200mg
Tasquinimod (CAS 254964-60-8) is an orally bioavailable quinoline-3-carboxamide compound with antiangiogenic and antitumor properties It modulates angiogenesis primarily through dual inhibition of S100A9/TLR4 signaling in myeloid-derived suppressor cells (MDSCs) and downregulation of HIF-1 and VEGF expression in tumor and endothelial cells It also enhances thrombospondin-1 (TSP-1) expression further suppressing neovascularization Preclinical studies in human prostate cancer xenograft models indicate significant antineoplastic activity particularly in combination with docetaxel radiation therapy or androgen-depletion strategies suggesting its therapeutic potential for castration-resistant prostate cancer (CRPC)
Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It is intended for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). For research use only; not for sale to patients.
- Potent and specific Menin-MLL inhibitor.
- Applicable for research in MLL-rearranged acute leukemias (ALL and AML).
- Shows in vivo plasma IC50 of 53 nM.
- Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo.
Apexbio Technology LLC ZM 241385 139180-30-6 200mg
ZM 241385 is a selective high-affinity antagonist targeting the adenosine A2A receptor (A2AR) It is designed to inhibit A2AR-mediated signaling thereby modulating receptor-specific downstream pathways ZM 241385 exerts its biological activity primarily through competitive inhibition of A2AR It demonstrates antagonistic activity with a Ki value of approximately 1 4 nM Based on these pharmacological properties ZM 241385 holds research potential in studies of neurodegenerative disorders cardiovascular conditions and A2AR-mediated neuronal signaling pathways
Medchemexpress LLC Vidarabine monohydrate | 24356-66-9 | 100 MG
Vidarabine monohydrate is an adenine arabinoside and an antiviral agent. It is active against herpes simplex viruses (HSV) and varicella zoster viruses. This product is for research use only and not sold to patients.
- Antiviral agent
- Active against herpes simplex viruses (HSV)
- Active against varicella zoster viruses
- Soluble in DMSO (250 mg/mL)
- For research use only
Apexbio Technology LLC LY2940680 1258861-20-9 200mg
LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations
Apexbio Technology LLC Rimantadine 13392-28-4 200mg
Rimantadine (13392-28-4) is a small-molecule inhibitor targeting the M2 ion channel protein of influenza A virus It is designed to specifically block the M2 channel thereby inhibiting the viral uncoating process and preventing subsequent viral entry into host cells Rimantadine exerts its biological activity primarily through inhibition of the M2 ion channel In in vitro studies rimantadine demonstrates antiviral activity with reported IC50 values typically ranging from approximately 0 1 to 1 M depending on virus strain and experimental context Based on these pharmacological properties rimantadine holds research potential in investigating influenza A viral replication resistance mutations infection pathways and in evaluating antiviral activity and establishing infection models in vitro
Medchemexpress LLC GSK547 200mg | 2226735-55-1 | 200 MG
GSK547 is a potent, selective small-molecule inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1) used in preclinical research to investigate necroptosis, inflammation, and macrophage-mediated immune tolerance. The compound has molecular formula C20H18F2N6O, molecular weight 396.39 g/mol, and vendor-reported purity of 99.92%. It is supplied in research quantities and as solution formulations for experimental use.
- Inhibits RIPK1 with high potency and selectivity.
- Molecular formula C20H18F2N6O; molecular weight 396.39 g/mol.
- Vendor-reported high purity (~99.9%).
- Available as a 200 mg solid and as DMSO solutions (10 mM).
- Suitable for in vitro and preclinical in vivo research applications.
TARGETMOL CHEMICALS INC ZINC12409120 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 uM.ZINC12409120 inhibits ERK activity by interfering with FGF23(alpha)-Klotho interaction. purity: 99%