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Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1

Medchemexpress LLC U0126-EtOH | 1173097-76-1 | 98.9% | 200MG
SDP

U0126-EtOH | 1173097-76-1 | 98.9% | 200MG

ENCOMPASS_PREFERRED
2

Medchemexpress LLC SCH772984 | 942183-80-4 | 99.8% | C33H33N9O2 | 200 MG
SDP

SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 nM for ERK1 and 1 nM for ERK2. It exhibits antitumor activity in both MAPK inhibitor-naive and MAPK inhibitor-resistant cells that contain BRAF or RAS mutations.

  • Highly selective and ATP-competitive ERK inhibitor
  • Exhibits antitumor activity in MAPK inhibitor-naive and resistant cells
  • Induces G1 arrest and apoptosis in sensitive melanoma cells
  • Inhibits ERK and RSK phosphorylation
  • Shows EC50 values less than 500 nM in BRAF-mutant and RAS-mutant tumor lines
  • Leads to significant tumor regression in animal models
  • Well tolerated in vivo

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3

Apexbio Technology LLC SCH772984 TFA 942183-80-4 (free base) 200mg
SDP

SCH772984 TFA is a small-molecule inhibitor targeting extracellular signal-regulated kinase 1/2 (ERK1/2) It is designed to inhibit ERK catalytic activity thereby blocking phosphorylation of downstream substrates and regulating the RAS-RAF-MEK-ERK signaling pathway SCH772984 TFA exerts its biological activity primarily through direct interaction with ERK1/2 acting as an ATP-competitive inhibitor Based on these pharmacological properties SCH772984 TFA holds research potential in studies examining ERK signaling s role in oncogenic pathway activation tumor cell growth survival mechanisms and resistance phenomena in various cancer models

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4

Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | >90.0% | C37H48N6O10S3 | 10MG
SDP

Sulfo-Cy5 azide is a water-soluble, azide-functionalized fluorescent dye intended for bioconjugation via click chemistry. It absorbs at 647 nm and emits at 663 nm, and is supplied as a blue powder with a molecular weight of approximately 833.01 g/mol and reported purity ≥90% (HPLC). The reagent is designed for labeling biomolecules in aqueous conditions and should be stored at -20 °C.

  • Water-soluble for efficient labeling in aqueous buffers.
  • Provides far-red fluorescence (λabs 647 nm, λem 663 nm) for imaging and detection.
  • Azide functionality enables copper-catalyzed and strain-promoted click chemistry conjugation.
  • High purity (>90.0%) suitable for sensitive applications.
  • Blue powder form for easy aliquoting and storage.
  • Stable when stored at -20 °C with a typical shelf life of 12 months.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 98.97% | C37H48N6O10S3 | 50 MG
SDP

Sulfo-Cy5 azide | 1782950-80-4 | 98.97% | C37H48N6O10S3 | 50 MG

ENCOMPASS_PREFERRED
6

Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 99.0% | C37H48N6O10S3 | 25 MG
SDP

Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. It is used for fluorescence imaging, enabling visualization of PD-L1 in tumors, site-specific modification of anti-PD-L1 antibodies, and RNA labeling. The probe can also be conjugated for imaging in atherosclerosis and breast cancer models.

  • Exhibits favorable click chemistry reactivity
  • Used for fluorescence imaging of PD-L1 in tumors
  • Facilitates site-specific modification of anti-PD-L1 antibodies
  • Applied in RNA labeling and imaging
  • Can be conjugated for imaging in atherosclerosis and breast cancer models
  • Detects ADP-ribosylation events via click chemistry
  • Conjugates to alkyne-functionalized TMV coat proteins (CuAAC)

ENCOMPASS_PREFERRED
7

Medchemexpress LLC Sulfo-Cy5 azide | 1782950-80-4 | 98.97% | C37H48N6O10S3 | 100 MG
SDP

Sulfo-Cy5 azide is a near-infrared fluorescent probe that exhibits favorable click chemistry reactivity. It is used for fluorescence imaging, tissue and cellular visualization, and site-specific modification of antibodies. It can also be applied for RNA labeling and imaging and conjugated to targeting agents for fluorescence imaging in models of atherosclerosis and breast cancer.

  • Near-infrared fluorescent probe
  • Favorable click chemistry reactivity
  • Enables fluorescence imaging
  • Used for tissue and cellular visualization of PD-L1 in tumors
  • Allows site-specific modification of anti-PD-L1 antibodies
  • Applicable for RNA labeling and imaging
  • Can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models

ENCOMPASS_PREFERRED
8

Medchemexpress LLC 2(1H)-Quinolinone, 8-hydroxy- | 15450-76-7 | 99.9% | 161.16 | 1 G
SDP

2,8-Quinolinediol, also known as 8-Hydroxy-2(1H)-quinolinone, is a biochemical reagent. It serves as a biological material or organic compound, primarily intended for various life science-related research applications. This product is for research use only and not for medical or patient use.

  • Biochemical reagent
  • Used as a biological material or organic compound
  • Intended for life science research
  • Not validated for medical applications

ENCOMPASS_PREFERRED
9

Medchemexpress LLC 4-[2-(4-nitro-1H-imidazol-1-yl)ethyl]morpholine | 6497-78-5 | MFCD02029312 | >98.0% | 226.24 | C9H14N4O3 | 5 MG
SDP

RGW-611 (4-[2-(4-nitro-1H-imidazol-1-yl)ethyl]morpholine) is a morpholine derivative used in laboratory research; it has been reported to enhance radiation-induced cell death in hypoxic cell models and to stimulate fatty acid synthesis. The compound is supplied in small quantities for in vitro studies and requires controlled storage to maintain stability.

  • Chemical name: 4-[2-(4-nitro-1H-imidazol-1-yl)ethyl]morpholine.
  • CAS number: 6497-78-5.
  • Molecular formula: C9H14N4O3.
  • Molecular weight: 226.24 g/mol.
  • Purity: >98.0% (HPLC).
  • Available sizes: 1 mg, 5 mg, 10 mg.
  • Storage: 4°C, protect from light; in solvent store at -80°C for long-term.

ENCOMPASS_PREFERRED
10

Medchemexpress LLC HCV-IN-31 | 1998705-62-6 | 99.7% | 312.30 | 25 MG
SDP

HCV-IN-31 (compound 4) is a potent inhibitor of the Hepatitis C Virus (HCV) replicon, demonstrating an EC50/EC95 of 15.7 μM. This compound is provided as a white to off-white solid, suitable for various research applications.

  • High purity of 99.7%
  • Molecular weight: 312.30
  • Molecular formula: C12H17FN6O3
  • CAS number: 1998705-62-6
  • Recommended storage: 4°C, protect from light
  • In solvent storage: -80°C for 6 months, -20°C for 1 month (protect from light)

ENCOMPASS_PREFERRED
11

Medchemexpress LLC 6-Bromoisoquinoline | 34784-05-9 | 98.2% | C9H6BrN | 25 G
SDP

6-Bromoisoquinoline is a biochemical reagent used as a biological material or organic compound for life science research. It serves as a synthetic intermediate for pharmaceutical synthesis.

  • Biochemical reagent for life science research
  • Synthetic intermediate for pharmaceutical synthesis
  • Store powder at -20°C for 3 years or 4°C for 2 years
  • Store in solvent at -80°C for 6 months or -20°C for 1 month

ENCOMPASS_PREFERRED
12

Medchemexpress LLC 5-amino-6-chloro-n-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-a]pyridine-8-carboxamide | 519148-48-2 | 98.3% | 377.91 g/mol | C19H28ClN5O | 200 MG
SDP

CJ033466 is a research-grade selective 5-HT4 receptor partial agonist with a reported EC50 of 9 nM and demonstrated gastroprokinetic activity. It is supplied as a purified solid intended for in vitro and in vivo pharmacology research.

  • Selective 5-HT4 receptor partial agonist (EC50 9 nM).
  • Reported gastroprokinetic activity in preclinical studies.
  • High purity (98.29%), suitable for pharmacology research.
  • Molecular formula C19H28ClN5O; molecular weight 377.91 g/mol.
  • Soluble in DMSO (50 mg/mL) with ultrasonic/warming up to 80°C.
  • Storage: solid at 4°C; in solvent -80°C (6 months), -20°C (1 month).
  • Available in research quantities including 200 mg.

ENCOMPASS_PREFERRED
13

Medchemexpress LLC 2-Aminobenzenesulfonamide | 3306-62-5 | 99.9% | 200 MG
SDP

2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor. It is for research use only.

  • Appearance: Solid
  • Color: White to light brown
  • Molecular weight: 172.20
  • Formula: C6H8N2O2S
  • Shipping: Room temperature in continental US; may vary elsewhere
  • Storage: Powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year

ENCOMPASS_PREFERRED
14

Medchemexpress LLC 1-tert-Butyl-3-ethoxybenzene | 133073-81-1 | 95.0% | C12H18O | 1 G
SDP

1-tert-Butyl-3-ethoxybenzene is a chemical compound that serves as a drug intermediate, crucial for the synthesis of various active pharmaceutical compounds.

  • Appearance: liquid, light yellow to light brown
  • Purity: 95.0%
  • Molecular weight: 178.28
  • Storage (pure form): -20°C for 3 years, 4°C for 2 years
  • Storage (in solvent): -80°C for 6 months, -20°C for 1 month

ENCOMPASS_PREFERRED
15

Medchemexpress LLC 4H-1-benzopyran-4-one, 7-methoxy-3-(4-methoxyphenyl)-d6 | 1 MG
SDP

4',7-Dimethoxyisoflavone-d6 is a deuterium-labeled flavonoid derived from Albizia julibrissin, known for its antifungal properties. This compound is intended for research use only, particularly in studies examining the impact of deuterium substitution on pharmacokinetics and metabolic profiles.

  • Isotope-labeled compound
  • Purity: 98.82%
  • Appearance: Light yellow to yellow solid
  • Storage for powder: -20°C for 3 years or 4°C for 2 years
  • Storage in solvent: -80°C for 6 months or -20°C for 1 month
  • Ships at room temperature
  • Soluble in DMSO; other solvents include H₂O, Ethanol, or DMF

ENCOMPASS_PREFERRED