Quinolines and derivatives
TARGETMOL CHEMICALS INC AL 8697 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AL 8697 is a selective p38(alpha) MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38(beta) (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity. purity: 99%
Medchemexpress LLC Al-611 | 2481279-61-0 | 99.9% | C25H33F2N6O8P | 10MG
AL-611 is a research-grade small-molecule inhibitor described by the manufacturer as an HCV protease inhibitor intended for laboratory research use. It is supplied as a white to off-white solid and is characterized by a high reported purity and defined molecular properties.
- Potent HCV protease inhibitor for laboratory research.
- High purity (99.93%).
- White to off-white solid, suitable for analytical and biological assays.
- Molecular weight 614.54 Da; molecular formula C25H33F2N6O8P.
- Datasheet, certificate of analysis, and safety data sheet available.
- Intended for research use only, not for human or veterinary use.
Medchemexpress LLC AL-611 | 2481279-61-0 | 99.9% | C25H33F2N6O8P | 1 MG
AL-611 is an HCV NS5B polymerase inhibitor with an EC50 of 5 nM. It targets HCV Protease and is involved in anti-infection and metabolic enzyme/protease pathways.
- HCV NS5B polymerase inhibitor (EC50 = 5 nM)
- Targets HCV Protease
- Involved in anti-infection and metabolic enzyme/protease pathways
- Molecular weight: 614.54
- Soluble in DMSO at 125 mg/mL (requires ultrasonication)
- Appears as a white to off-white solid
- Used in research for chronic Hepatitis C treatment
Medchemexpress LLC AL-611 | 2481279-61-0 | 99.9% | C25H33F2N6O8P | 1 ML
AL-611 is an HCV NS5B polymerase inhibitor with an EC50 of 5 nM, intended for research use only.
- Molecular weight of 614.54.
- Purity of 99.93%.
- Appears as a solid, white to off-white.
- Soluble in DMSO (125 mg/mL).
- Store powder at -20°C for up to 3 years.
- Store in solvent at -80°C for 6 months, or -20°C for 1 month.
- Exhibits CC50 > 100 μM and EC50 0.005 μM in Huh-7 cells.
- Involved in a Phase 1 clinical trial for Hepatitis C (NCT03253471).
Medchemexpress LLC Z-Leu-Leu-Leu-al | 133407-82-6 | MFCD00674886 | 99.9% | 475.6 | 200 MG
MG-132 is a potent and reversible proteasome inhibitor with an IC50 of 100 nM. It also acts as a calpain inhibitor with an IC50 of 1.2 μM. It effectively blocks the proteolytic activity of the 26S proteasome complex, acts as an autophagy activator, and induces apoptosis.
- Potent and reversible proteasome inhibitor
- Blocks proteolytic activity of the 26S proteasome complex
- Acts as an autophagy activator
- Induces apoptosis
- Calpain inhibitor
Medchemexpress LLC Sugar-modified guanosine analogue | 2481279-61-0 | 99.9% | 614.54 | C25H33F2N6O8P | 5 MG
AL-611 is a research-use small-molecule HCV NS5B polymerase inhibitor described as a sugar-modified guanosine analogue with potent antiviral activity (EC50 = 5 nM). It is supplied as a high-purity solid and is intended for laboratory research only, not for human or clinical use.
- Potent HCV NS5B polymerase inhibition (EC50 = 5 nM).
- Sugar-modified guanosine analogue class of compound.
- Molecular weight 614.54 g·mol-1.
- Chemical formula C25H33F2N6O8P.
- High purity, reported as 99.9% by HPLC.
- Available in small-milligram sizes, with a 10 mM in 1 mL DMSO solution option.
- For research use only; not for human or clinical use.
Medchemexpress LLC Rivastigmine (tartrate) | 129101-54-8 | MFCD03700731 | 99.03% | 400.42 | 50 MG
Rivastigmine tartrate is an orally active and potent cholinesterase (ChE) inhibitor. It inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). This compound can pass the blood-brain barrier (BBB) and is used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
- Orally active and potent cholinesterase (ChE) inhibitor
- Inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)
- Can pass the blood-brain barrier (BBB)
- Used for research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease
- Reduces LPS-induced TNF-α and IL-6 in vitro
- Improved behavioral impairments caused by Aluminum in male Wistar albino rats
- Reduced IL-6 concentration in BALB/c OlaHsd male mice with acute colitis