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4-Thiouridine 5′-triphosphate tetralithium (4-Thio-UTP) is a UTP analog and a potent P2Y2 and P2Y4 receptor agonist, with EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. This compound is a light yellow to yellow solid suitable for various research applications.
UTP analog
Potent P2Y2 and P2Y4 receptor agonist
Suitable for cross-linking experiments
Suitable for transcriptional complex labeling studies
Ships at room temperature in the continental US
Store at 4°C, sealed, away from moisture and light
For research use only
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4-Thiouridine 5'-triphosphate tetralithium (4-Thio-UTP tetralithium) is a UTP analog and a potent P2Y2 and P2Y4 agonist, with EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4. This laboratory chemical is suitable for cross-linking experiments and transcriptional complex labeling studies. It is for research use only and has not been fully validated for medical applications.
Potent P2Y2 and P2Y4 agonist
EC50 values of 35 nM for hP2Y2 and 350 nM for hP2Y4
Suitable for cross-linking experiments
Useful in transcriptional complex labeling studies
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2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. It antagonizes BH4-induced nNOS dimerization and has been observed to stimulate the growth of pea and corn root segments. Additionally, it functions as an antithyroid compound and a highly specific melanoma detector.
Functions as a selective neuronal nitric oxide synthase (nNOS) inhibitor
Antagonizes BH4-induced nNOS dimerization
Acts as an antithyroid compound
Serves as a highly specific melanoma detector
Stimulates growth of pea and corn root segments
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2-Thiouracil (CAS 141-90-2) is a sulfur-containing derivative of uracil that functions as an inhibitor of thyroid hormone synthesis It exerts its antihyperthyroid effects by interfering with the enzymatic iodination of tyrosine residues within thyroglobulin thereby suppressing the production of triiodothyronine (T3) and thyroxine (T4) Due to its capacity to modulate thyroid function 2-Thiouracil is utilized in biomedical research to study thyroid hormone regulation and associated disorders as well as to model hypothyroid states in experimental settings
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4-Thiouridine is a ribonucleoside analog widely used in RNA analysis and (m)RNA labeling. It inhibits rRNA synthesis and causes a nucleolar stress response.
Ribonucleoside analog
Used in RNA analysis and (m)RNA labeling
Inhibits rRNA synthesis
Causes a nucleolar stress response
At 0-10 μM, it labels and purifies nascent rRNA without significantly affecting rRNA synthesis
At ≥50 μM, it strongly inhibits production and processing of rRNA
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