Thiophenes
Medchemexpress LLC Thiophene-2 | 5MG
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 M and has potent anti-tuberculosis activity[1]
Medchemexpress LLC Puromycin dihydrochloride | 58-58-2 | MFCD00012691 | 99.9% | 500 MG
Puromycin dihydrochloride is an aminonucleoside antibiotic that inhibits protein synthesis. It blocks protein synthesis after aminoacyl-sRNA formation, leading to the accumulation of small peptides. It induces premature termination of translation by serving as an acceptor substrate and by competing with aminoacyl-tRNA for binding to the A' site. This allows for direct evaluation of translation activity in single cells using immunofluorescence microscopy and in heterogeneous cell populations via fluorescence-activated cell sorting.
- Aminonucleoside antibiotic
- Inhibits protein synthesis
- Blocks protein synthesis after aminoacyl-sRNA formation
- Leads to the accumulation of small peptides
- Causes premature termination of translation
- Allows direct evaluation of translation activity in single cells by immunofluorescence microscopy and in heterogeneous cell populations by fluorescence-activated cell sorting
Medchemexpress LLC DRB18 | 2863686-81-9 | 99.6% | C22H23ClN2O2 | 100 MG
DRB18 is a potent pan-class GLUT inhibitor that alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. It can lead to G1/S phase arrest, increase oxidative stress, and cause necrotic cell death, while also exhibiting anti-tumor activity.
- Potent pan-class GLUT inhibitor
- Alters energy-related metabolism in A549 cells
- Leads to G1/S phase arrest
- Increases oxidative stress
- Causes necrotic cell death
- Exhibits anti-tumor activity
- Reduces glucose uptake in GLUT1-4-expressed HEK293 cell lines
- Decreases expression of GLUT1-4 in xenografted tumors
- Reduces proliferative capacity within xenografted tumors
Medchemexpress LLC Thiophene-3-carboxylic acid | 88-13-1 | 128.15 | 25 G
Thiophene-3-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It has been used in the preparation of novel acetylene monomer, required for the synthesis of poly(2-methylbut-2-enyl thiophene-3-carboxylate) and oxazolines and oxazoles. It is also used as a leading compound for the development of a clinically useful D-amino acid inhibitor and has the potential to serve as active site probes to elucidate the structure-function relationships of D-amino acids.
- Used as a biochemical reagent for life science research.
- Can be used as a biological material or organic compound.
- Prepares novel acetylene monomer for various syntheses.
- Serves as a leading compound for D-amino acid inhibitor development.
- Potential for elucidating structure-function relationships of D-amino acids.
Medchemexpress LLC Puromycin dihydrochloride | 58-58-2 | 99.9% | 1 ML
Puromycin dihydrochloride is an aminonucleoside antibiotic that inhibits protein synthesis by blocking aminoacyl-sRNA formation, leading to the accumulation of small peptides. It causes premature termination of translation by linking non-specifically to growing polypeptide chains. When used in minimal amounts, puromycin incorporation in newly synthesized proteins directly reflects the rate of mRNA translation in vitro.
- Acts as an analog of the 3' end of aminoacyl-tRNA.
- Inhibits protein synthesis by interfering with translation.
- Can be used for direct evaluation of translation activity in single cells by immunofluorescence microscopy.
- Suitable for heterogeneous populations of cells by fluorescence-activated cell sorting.
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | ≥98% | 581.71 | 1 ML
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells, leading to mitochondrial apoptosis. It also exhibits broad-spectrum antifungal and antibiofilm activity against various fungal pathogens, including fluconazole-resistant strains and mature biofilms.
- Targets mitochondrial tyrosine phosphatase (PTPMT1).
- Induces mitochondrial apoptosis.
- Shows broad-spectrum antifungal activity against diverse fungal pathogens.
- Effective against fluconazole-resistant Candida isolates.
- Inhibits filamentation and proliferation of fungi.
- Decimates mature biofilms of Candida, Cryptococcus, and Aspergillus species at low concentrations.
- Inhibits lateral yeast formation and biofilm dispersal in C. albicans.
- Reduces fungal biofilm growth and viability by 67% in C. albicans murine models.