Guanidines
Sigma Aldrich 3-Methyl-5-(phenoxymethyl)-2-furoic acid
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Chlorhexidine dihydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 4-bromo-1-(pyridin-3-ylmethyl)-1H-pyrazole
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 1,1-Dimethylbiguanide hydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC Metformin hydrochloride | 1115-70-4 | MFCD00012582 | 100.0% | 165.62 | C4H12ClN5 | 10 MG
Metformin hydrochloride is the hydrochloride salt of metformin supplied as an analytical reference standard for use in analytical chemistry, method development, and research. It is identified by CAS 1115-70-4, has formula C4H12ClN5, and a molecular weight of 165.62.
- High purity suitable for analytical assays (reported 99.97%).
- Provided as a 10 MG package for calibration and method development.
- Highly soluble in water and PBS (≥100 mg/mL); limited solubility in DMSO.
- Storage: keep sealed at 4°C; follow solvent storage guidelines for long-term stability.
- Intended for use as an analytical reference in validation, quality control, and research workflows.
Medchemexpress LLC Metformin | 657-24-9 | 100 MG
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, which makes it useful for the study of type 2 diabetes. It also exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons, and inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. Additionally, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway.
- Inhibits mitochondrial respiratory chain
- Enhances insulin sensitivity
- Reduces liver oxidative and nitrosative stress
- Regulates autophagy-related proteins
- Inhibits tumor cell autophagy and growth of renal cell carcinoma
Selleck Chemical LLC Metformin
Metformin (1 1-Dimethylbiguanide) a widely used drug for treatment of type 2 diabetes activates AMP-activated protein kinase (AMPK) in hepatocytes Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
Selleck Chemical LLC Metformin
Metformin (1 1-Dimethylbiguanide) a widely used drug for treatment of type 2 diabetes activates AMP-activated protein kinase (AMPK) in hepatocytes Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
Selleck Chemical LLC Metformin
Metformin (1 1-Dimethylbiguanide) a widely used drug for treatment of type 2 diabetes activates AMP-activated protein kinase (AMPK) in hepatocytes Metformin promotes mitophagy in mononuclear cells Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
TARGETMOL CHEMICALS INC BIOE-1115 5MG
Also available in 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2(alpha) (IC50 = 10 uM). purity: 97%
Medchemexpress LLC Metformin hydrochloride | 1115-70-4 | 99.9% | 165.62 | 25 MG
Metformin hydrochloride (Standard) is an analytical standard intended for research and analytical applications. It inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. It also exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Additionally, it inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. It regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
- Analytical standard
- Used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS
- Appearance: Solid
- Color: White to off-white
FUJIFILM BIOSCIENCES INC Metformin hydrochloride
Metformin Hydrochloride is is one of the biguanides It suppresses glyconeogenesis in the liver facilitates peripheral use of glucose and inhibits glucose absorption from the intestinal tract via activation of AMPK AMP-activated protein kinase resulting in hypoglycemic effects It has been widely used as a drug to treat type 2 diabetes mellitus in clinical practices as showing hypoglycemic effects independent of insulin secretion in the pancreatic b-cell
Apexbio Technology LLC Metformin HCl 1115-70-4 10g
Metformin hydrochloride (Metformin HCl CAS 1115-70-4) is a widely studied small molecule employed in biomedical research primarily for investigating glucose metabolism and type 2 diabetes mechanisms It acts through selective inhibition of hepatic gluconeogenesis without directly increasing insulin secretion The molecular targets include activation of AMP-activated protein kinase (AMPK) subsequently suppressing acetyl-CoA carboxylase (ACC) activity attenuating lipid biosynthesis and promoting fatty acid oxidation Additionally metformin inhibits mitochondrial glycerophosphate dehydrogenase (mGPD) changing cellular redox status and reducing lactate-driven gluconeogenesis pathways Key research applications of Metformin HCl include studies on glucose homeostasis metabolic disorders and AMPK signaling cascades
Medchemexpress LLC Metformin hydrochloride (standard) | 1115-70-4 | 99.97% | 165.62 | 5 MG
Metformin hydrochloride (Standard) is an analytical standard for research and analytical applications. It inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, useful for type 2 diabetes studies. It also inhibits liver oxidative stress and inflammation, and regulates autophagy to inhibit renal cell carcinoma growth.
- Analytical standard for research and analytical applications.
- Inhibits mitochondrial respiratory chain in the liver.
- Activates AMPK and enhances insulin sensitivity.
- Used in type 2 diabetes research.
- Inhibits liver oxidative stress and inflammation.
- Regulates autophagy-related proteins.
- Inhibits mTOR signaling pathway.
- Induces tumor cell autophagy and inhibits renal cell carcinoma growth.
- Suitable for HPLC, GC, and MS research.
Medchemexpress LLC Metformin (hydrochloride) | 1115-70-4 | 100.0% | 165.62 | 100 MG
Metformin hydrochloride is a compound that inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, useful in type 2 diabetes research. It also lowers glucose by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons and reduces liver oxidative stress, inflammation, and apoptosis. Additionally, it regulates autophagy and inhibits renal cell carcinoma growth by activating AMPK and inhibiting the mTOR pathway.
- Inhibits mitochondrial respiratory chain
- Activates AMPK and enhances insulin sensitivity
- Used for type 2 diabetes research
- Lowers glucose by inhibiting Rap1
- Reduces liver oxidative stress, inflammation, and apoptosis
- Regulates autophagy by activating AMPK
- Inhibits mTOR signaling pathway
- Induces tumor cell autophagy
- Inhibits renal cell carcinoma growth in vitro and in vivo