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Medchemexpress LLC 5-(N,N-Hexamethylene)-amiloride | 1428-95-1 | 99.1% | 50 MG
5-(N,N-Hexamethylene)-amiloride is a derivative of amiloride and acts as a potent inhibitor of the Na+/H+ exchanger. This inhibition leads to a decrease in intracellular pH (pHi) and triggers apoptosis in leukemic cells. Additionally, it functions as an inhibitor of the HIV-1 Vpu virus ion channel. It has been shown to inhibit the replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV229E) in cultured L929 cells, with EC50 values of 3.91 μM and 1.34 μM, respectively.
- Potent Na+/H+ exchanger inhibitor.
- Decreases intracellular pH (pHi).
- Induces apoptosis in leukemic cells.
- Inhibits HIV-1 Vpu virus ion channel.
- Inhibits mouse hepatitis virus (MHV) replication.
- Inhibits human coronavirus 229E (HCoV229E) replication.
- Available in solid form, light yellow to yellow in color.
- Purity of 99.1%.
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