Oximes
Apexbio Technology LLC Indirubin-3'-oxime 160807-49-8 5mg
Indirubin-3 -oxime (CAS 160807-49-8) is a derivative of indirubin investigated primarily as an inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 22 nM This compound also inhibits CDK5/p25 and CDK1/cyclin B with IC50 values of around 100 nM and 180 nM respectively while demonstrating weaker inhibitory activity against 5-lipoxygenase (IC50 7 8 10 M) Due to its modulation of multiple kinases involved in cell signaling Indirubin-3 -oxime is widely utilized in research on cellular signaling pathways and the molecular mechanisms underlying disease
TARGETMOL CHEMICALS INC Indirubin-3-monoxime 25MG
Also available in 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3beta (IC50 22 nM) and also inhibits CDKs ( (IC50s 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). Purity 99.65%
eMolecules Key Organics/BIONET Benzaldoxime 1mg 564164950 PS-5120 95 000 932-90-1 MFCD00002119 121 139 C7H7NO
Key Organics/BIONET Benzaldoxime 1mg 564164950 PS-5120 95 000 932-90-1 MFCD00002119 121 139 C7H7NO
Medchemexpress LLC Taraxerol | 127-22-0 | 5 MG
Taraxerol is an anti-inflammatory and anti-cancer agent isolated from Taraxacum mongolicum. It attenuates acute inflammation by inhibiting the NF-κB signaling pathway and also induces cell apoptosis.
- Isolated from Taraxacum mongolicum
- Attenuates acute inflammation by inhibiting the NF-κB signaling pathway
- Induces cell apoptosis
- Appears as a solid, white to yellow color
- Soluble in THF (10 mg/mL with ultrasonic), insoluble or slightly soluble in DMSO, and insoluble in H2O
- Purity is 98.0%
Medchemexpress LLC Cymoxanil | 57966-95-7 | 99.6% | 500 MG
Cymoxanil is a fungicidal cyanooxime that targets plant diseases caused by fungi belonging to the Perenosporales. It affects growth, DNA, and RNA synthesis in Phytophthora.
- Targets fungal plant diseases belonging to Perenosporales
- Impacts growth, DNA, and RNA synthesis in Phytophthora
- Highly sensitive against colony growth and germ tube emergence of Phytophthora infestans sporangia and encysted zoospores (ED50: 0.5-1.5 μg/mL)
- Insignificant histopathological changes in treated rats at low doses
- Exhibits adverse signs and symptoms of toxicity at medium and high doses
- Hepatotoxicity and nephrotoxicity observed in rats at higher doses
Medchemexpress LLC Cymoxanil | 57966-95-7 | 100 MG
Cymoxanil is a fungicidal cyanooxime that targets plant diseases caused by fungi belonging to the Perenosporales. It affects the growth, DNA, and RNA synthesis in Phytophthora. Colony growth and germ tube emergence of sporangia and encysted zoospores of Phytophthora infestans are highly sensitive to Cymoxanil (ED50: 0.5-1.5 μg/mL).
Medchemexpress LLC 2,3-butanedione monoxime | 57-71-6 | MFCD00002116 | 98.0% | 101.10 g/mol | C4H7NO2 | 1mL
Biacetyl monoxime (Diacetyl monoxime) a myosin ATPase inhibitor is a skeletal and cardiac muscle contraction inhibitor Biacetyl monoxime is also a well-characterized non-competitive inhibitor of chemical and motile activity of skeletal muscle myosin-II Biacetyl monoxime induces sarcoplasmic reticulum Ca2 release[1][2][3]
Medchemexpress LLC Propan-2-one oxime | 127-06-0 | 99.9% | 73.09 | 1 KG
Propan-2-one oxime is a biological material or organic compound widely used in life science research.
- For research use only.
- Appearance: Solid
- Color: White to off-white
- Store powder at -20°C for 3 years, 4°C for 2 years.
- Store in solvent at -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Cymoxanil | 57966-95-7 | 99.6% | 5 G
Cymoxanil is a fungicidal cyanooxime that targets plant diseases caused by fungi belonging to the Perenosporales. It works by affecting the growth, DNA, and RNA synthesis in Phytophthora.
- Fungicidal cyanooxime.
- Targets plant diseases caused by fungi belonging to the Perenosporales.
- Affects growth, DNA, and RNA synthesis in Phytophthora.
eMolecules 859160-67-1 | (E)-(2-((hydroxyimino)methyl)phenyl)boronic acid | MFCD22192227 | 1g
WuXi ChemSupply | (E)-(2-((hydroxyimino)methyl)phenyl)boronic acid | 1g | 599170700 | LN03271158 | 95.000 | 859160-67-1 | MFCD22192227 | 164.960 | C7H8BNO3
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Chemscene ChemScene | Ethyl (E)-2-cyano-2-(hydroxyimino)acetate | 10G | CS-0019125 | 0.97 | 56503-39-0| MFCD00002112 | 142.11
ChemScene | Ethyl (E)-2-cyano-2-(hydroxyimino)acetate | 10G | CS-0019125 | 0.97 | 56503-39-0| MFCD00002112 | 142.11
Medchemexpress LLC Glucosylceramide synthase-IN-2 | 2597958-02-4 | 98.62% | C22H20F3N3O4 | 1 ML
Glucosylceramide synthase-IN-2 is a potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS). It demonstrates IC50 values of 15 nM for human GCS and 190 nM for mouse GCS, exhibiting noncompetitive inhibition with C8-ceramide and UDP-glucose. This compound is applicable for research related to Gaucher's disease, showing no significant inhibitory activity against SERT or GCase in vitro. In vivo studies confirm good oral and brain exposure in mice, reducing GlcCer concentrations in plasma and cerebral cortex.
- Potent GCS inhibitor
- Brain-penetrant
- Orally active
- Noncompetitive inhibition type with C8-ceramide and UDP-glucose
- Useful for Gaucher's disease research
- Does not significantly inhibit SERT or GCase activity in vitro
- Shows good oral and brain exposure in vivo
BIOHIPPO Syn-JGCamP7b-Puro LV
Syn-JGCamP7b-Puro is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
