Alcohols and polyols
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- (13)
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- (1)
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- (1)
- (26)
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- (1)
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- (1)
- (462)
- (9)
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- (11)
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- (1)
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- (145)
- (114)
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- (1)
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- (1)
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- (2)
- (2)
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- (1)
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- (7)
- (3)
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- (1)
- (36)
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- (2)
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- (33)
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- (7)
- (2)
- (1)
- (26)
- (1)
- (1)
- (1)
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- (1)
- (3)
- (4)
- (3)
- (1)
- (15)
- (12)
- (1)
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- (2)
- (7)
- (12)
- (1)
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- (24)
- (1)
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- (1)
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- (1)
- (17)
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- (1)
- (1)
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- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Alectinib (Hydrochloride) | 1256589-74-8 | 99.9% | 100 MG
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Alectinib Hydrochloride is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner). It effectively inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively, and demonstrates effective central nervous system (CNS) penetration.
- Potent, selective, and orally available ALK inhibitor
- Effective central nervous system (CNS) penetration
- Molecular formula: C30H35ClN4O2
- Molecular weight: 519.08
- Appearance: White to off-white solid
- Recommended storage at 4°C, sealed and away from moisture
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Midodrine hydrochloride | 43218-56-0 | 99.9% | 10 MG
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Midodrine hydrochloride is a selective and orally active adrenergic α1-receptor agonist. It strengthens vascular contraction and is utilized in research concerning cardiovascular diseases, such as orthostatic hypotension.
- Selective and orally active adrenergic α1-receptor agonist
- Strengthens vascular contraction
- Utilized in research for cardiovascular diseases like orthostatic hypotension
- Increases p-AMPK and PPARδ expression
- Increases Ca2+ in C2C12, HL1 and HepG2 cells
- Increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells
- Reduces cellular lipid content in 3T3-L1 cells
- Reduces platelet-activating factor-induced death in mice
- Shows anti-hypotensive effects in orthostatic hypotension rat models
- Relieves hypertension in spontaneously hypertensive rat models
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC CHK1-IN-4 hydrochlo | 1MG
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CHK1-IN-4 hydrochlo | 1MG
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Medchemexpress LLC Vimirogant hydrochloride | 1802678-42-7 | 98.4% | 552.65 g/mol | C27H35F3N4O3S·xHCl | 1 MG
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- Selective RORγt inhibition: Ki = 3.5 nM and IC50 = 17 nM.
- Reduces IL-17A secretion in multiple cell assays (reported IC50 values).
- High purity suitable for research applications (98.39%).
- Solid, light yellow appearance for ease of handling and storage.
- Storage stability: keep at 4°C, sealed and away from moisture; solvent stability specified for -80°C and -20°C.
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Medchemexpress LLC SGK1-IN-3 hydrochloride | 00-00-0 | 96.7% | 567.88 g/mol | C23H21Cl3N6O3S | 5 MG
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SGK1-IN-3 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1). It has reported potent activity (IC50 <1 μM) and is supplied as a solid research reagent for biochemical and cellular studies, including exploratory research in osteoarthritis.
- Potent SGK1 inhibition (IC50 <1 μM).
- Supplied as a solid suitable for biochemical and cellular assays.
- High reported purity for reliable experimental results.
- Available in small research pack sizes for screening and optimization.
- Useful for exploratory studies of SGK1-related pathways and disease models.
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Medchemexpress LLC Leonurine hydrochloride | 24735-18-0 | 99.4% | 347.79 | C14H22ClN3O5 | 10 MG
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Leonurine hydrochloride is the hydrochloride salt of leonurine, an alkaloid isolated from Leonurus artemisia. Supplied as a research-grade analytical standard, it is used in biochemical and pharmacological studies exploring antioxidant and anti-inflammatory activity.
- High purity suitable for analytical and research applications.
- Available in small quantities for assay development and validation.
- Stable as a sealed powder when stored at 4°C, away from moisture.
- Molecular weight 347.79 g/mol and formula C14H22ClN3O5.
- CAS number 24735-18-0; also known as SCM-198 hydrochloride.
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Medchemexpress LLC DC-BPi-11 hydrochloride | 00-00-0 | 97.0% | 433.95 g·mol⁻¹ | C20H24ClN5O2S | 5 MG
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DC-BPi-11 hydrochloride is a small-molecule BPTF inhibitor supplied as a hydrochloride salt in powder form for research use. It has demonstrated inhibition of leukemia cell proliferation and a reported IC50 of approximately 698 nM, with handling and storage guidance provided for both solid and solution states.
- Inhibitor of bromodomain PHD finger transcription factor (BPTF).
- Reported IC50 ≈ 698 nM.
- Powder hydrochloride salt form.
- Molecular formula C20H24ClN5O2S.
- Molecular weight 433.95 g·mol⁻¹.
- Purity 97.0%.
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Available as a 5 mg sample pack.
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Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 100.0% | 362.30 | 50 MG
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Clemizole hydrochloride is an H1 histamine receptor antagonist that has been shown to substantially inhibit HCV replication. It also acts as an inhibitor of the TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, while its EC50 for viral replication is 8 μM.
- Inhibits HCV RNA replication in cell culture.
- Suppresses NS4B's RNA binding.
- Offers minimal host cell toxicity.
- Functions as a novel inhibitor of TRPC5 channels.
- Efficiently blocks TRPC5 currents and Ca2+ entry in the low micromolar range.
- Exhibits six-fold selectivity for TRPC5 over TRPC4β.
- Displays almost 10-fold selectivity over TRPC3 and TRPC6.
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Medchemexpress LLC Terazosin hydrochloride dihydrate | 70024-40-7 | 99.9% | 50 MG
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Terazosin hydrochloride dihydrate is a quinazoline derivative, and it acts as a competitive and orally active α1-adrenoceptor antagonist. It functions by relaxing blood vessels and facilitating the opening of the bladder. This compound shows potential for treating benign prostatic hyperplasia (BPH) and high blood pressure. It is intended for research use only and is not sold to patients.
- Competitively blocks α1-adrenoceptors.
- Can be administered orally.
- Helps in relaxing blood vessels.
- Aids in the opening of the bladder.
- Has potential for the treatment of benign prostatic hyperplasia (BPH) and high blood pressure.
- Suitable for research applications.
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Medchemexpress LLC Leelamine hydrochloride | 16496-99-4 | 98.1% | 321.93 | 10 MG
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Leelamine hydrochloride is a tricyclic diterpene molecule extracted from the bark of pine trees. It acts as a cannabinoid receptor type 1 (CB1) agonist and an inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, functioning independently of androgen receptor status. It also suppresses the transcriptional activity of the androgen receptor, which regulates fatty acid synthesis.
- Cannabinoid receptor type 1 (CB1) agonist
- Inhibits SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells
- Suppresses transcriptional activity of androgen receptor
- Extracted from the bark of pine trees
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Medchemexpress LLC PhiKan 083 hydrochlo | 1050480-30-2 | 99.3% | 274.79 | 10 MG
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PhiKan 083 hydrochloride is a carbazole derivative that functions as a p53 Y220C stabilizer. It binds to the surface cavity of the Y220C (a p53 mutant) with a Kd of 167 μM and demonstrates a relative binding affinity (Kd) of 150 μM in Ln229 cells. This compound has been shown to slow down the thermal denaturation rate of p53 Y220C.
- Binds to the surface cavity of p53 Y220C mutant.
- Stabilizes p53 Y220C.
- Exhibits a Kd of 167 μM for p53 Y220C.
- Shows a relative binding affinity of 150 μM in Ln229 cells.
- Slows the thermal denaturation rate.
- Reduces cell viability of engineered Ln229 cell variants.
- Enhances pro-apoptotic activity in Ln229 cells when combined with NSC 123127.
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Medchemexpress LLC Leelamine hydrochloride | 16496-99-4 | 98.1% | 321.93 | 25 MG
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Leelamine hydrochloride is a tricyclic diterpene molecule extracted from the bark of pine trees. It acts as a cannabinoid receptor type 1 (CB1) agonist and an inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells. Its activity is not affected by androgen receptor status, and it suppresses the transcriptional activity of the androgen receptor.
- Tricyclic diterpene molecule
- Extracted from the bark of pine trees
- Cannabinoid receptor type 1 (CB1) agonist
- Inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells
- Suppresses transcriptional activity of androgen receptor
- Appearance: solid
- Color: white to off-white
- For research use only
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Medchemexpress LLC NNMT-IN-6 hydrochloride | 3031756-18-7 | 98.2% | C25H30ClN7O5 | 10MG
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NNMT-IN-6 hydrochloride is the hydrochloride salt of a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) intended for research use. It exhibits in vitro inhibitory activity (IC50 = 1.41 μM; Kd = 5.6 μM) and is supplied as a high-purity solid with documented solubility and storage recommendations for biochemical and cellular assays.
- High purity (98.2%).
- Confirmed NNMT inhibitory activity (IC50 = 1.41 μM; Kd = 5.6 μM).
- Hydrochloride salt form for improved solubility.
- Validated solubility in DMSO and water (250 mg/mL with sonication).
- Suitable for biochemical and cellular assays targeting NNMT.
- Recommended sealed storage away from moisture, with solvent stability guidelines.
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Medchemexpress LLC Pholedrine (hydrochloride) | 877-86-1 | 99.6% | 100 MG
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Pholedrine (hydrochloride) is an indirectly acting sympathomimetic amine supplied as a solid hydrochloride salt for laboratory research and substance manufacture. It has a reported molecular formula C10H16ClNO and a molecular weight of 201.69 g/mol.
- CAS 877-86-1
- Molecular formula C10H16ClNO
- Molecular weight 201.69 g/mol
- Appearance solid
- Recommended storage 4°C, sealed, away from moisture
- Purity 99.6% (LCMS)
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Medchemexpress LLC Viloxazine hydrochloride | 35604-67-2 | MFCD00661100 | 98.9% | 273.75 g/mol | C13H20ClNO3 | 50MG
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Viloxazine hydrochloride is a research-grade small molecule used as a selective norepinephrine transporter (NET) inhibitor and a modulator of serotonin (5-HT) receptors. Presented as the hydrochloride salt (CAS 35604-67-2) and supplied for preclinical laboratory use, it is commonly employed as a tool compound in studies of norepinephrine and serotonin signaling and in ADHD-related research.
- Research-grade hydrochloride salt with defined purity for laboratory use.
- Selective norepinephrine transporter inhibitor activity (IC50 = 0.26 μM).
- Modulates 5-HT receptors, including 5-HT2B antagonist and 5-HT2C agonist actions.
- Available in small pack sizes suitable for assays, including a 50 mg pack.
- Provided with molecular and analytical data to support traceability and reproducibility.
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