Thioureas
Medchemexpress LLC 2-Imidazolidinethione | 96-45-7 | ≥98.0% | 102.16 | 250 G
Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. It is recognized as tumorigenic and teratogenic, and is orally active.
- Degradation product of ethylenebisthiocarbamate fungicides.
- Tumorigenic and teratogenic agent.
- Orally active.
- Stable at elevated temperatures over a wide pH range.
- For research use only.
eMolecules 36822-11-4 | 6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one | MFCD00465574 | 1g
Medchem Express | MEDICA16 | 5mg | 716994246 | HY-P1123 | 87272-20-6 | MFCD00797684 | 342.520 | C20H38O4
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eMolecules 28456-54-4 | 5,6-Dimethyl-2-thiouracil | MFCD00278872 | 25g
Ambeed | 9-Propyl-9H-purin-6-amine | 250mg | 592283558 | A121142 | 707-98-2 | MFCD18801082 | 177.211 | C8H11N5
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Biomatik Corporation Puromycin, Dihydrochloride. Grade Biotechnology. Storage -20C. CAS 58-58-2
Puromycin, Dihydrochloride. Grade Biotechnology. Storage -20C. CAS 58-58-2
![eMolecules 36822-11-4 | 2-Mercapto-6-phenylpyrimidin-4(3h)-one | Combi-Blocks, Inc. | MFCD00847526 | 204.250 | C10H8N2OS | 95.000 | Sc1nc(cc(=O)[nH]1)-c1ccccc1 | 1g | 569293205](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502189899.JPG-250.jpg)
eMolecules 36822-11-4 | 2-Mercapto-6-phenylpyrimidin-4(3h)-one | Combi-Blocks, Inc. | MFCD00847526 | 204.250 | C10H8N2OS | 95.000 | Sc1nc(cc(=O)[nH]1)-c1ccccc1 | 1g | 569293205
2-Mercapto-6-phenylpyrimidin-4(3h)-one | Combi-Blocks, Inc. | 36822-11-4 | MFCD00847526 | 204.250 | C10H8N2OS | 95.000 | Sc1nc(cc(=O)[nH]1)-c1ccccc1 | 1g | 569293205
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
eMolecules 62-56-6 | Thiourea ACS Reagent Grade | Oakwood Chemicals | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 500g | 532150535
Thiourea ACS Reagent Grade | Oakwood Chemicals | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 500g | 532150535
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
AdipoGen 1-Azakenpaullone
Chemical. CAS 676596-65-9. Formula C15H10BrN3O. MW 328.2. Potent and ATP-competitive GSK-3beta glycogen synthase kinase-3beta inhibitor IC50 = 18 nM.
AdipoGen Z-Phe-Arg-AFC
Chemical. CAS 93753-73-2 free base. Formula C33H33F3N6O6 . C2HF3O2. MW 666.7 . 114.0. Synthetic. Fluorogenic substrate, specifically used to determine the enzyme activity of Cathepsin L. Useful for the study of cathepsin activity and for screening small molecule inhibitors for drug discovery and HTS applications. Likely to be cleaved by cathepsins B, F, K, S and L, cathepsins L-like proteases and proteases such as papain, cruzipain, plasma kallikrein, soybean trypsin-like enzyme and the falcipains-1 and -2 malaria hemoglobinases. Hydrolysis of this substrate is monitored by observing fluorescence at an Excitation of 400nm and Emission at 505nm.
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
AdipoGen SB202190
Chemical. CAS 152121-30-7. Formula C20H14FN3O. MW 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer
AdipoGen Z-Val-Leu-Arg-AMC
Chemical. Formula C35H47N7O7 . C2HF3O2. MW 677.8 . 114.0. Proteasome subunit alpha type-1 Macropain substrate used for assaying the trypsin-like activity of the 20S proteasome. Cysteine proteinase falcipain-2 and falcipain-3 malarial hemoglobinases substrate. Cathepsin S substrate. Hydrolysis of this fluorogenic peptide substrate is monitored by observing fluorescence at an Excitation of 345nm and Emission at 445nm.
AdipoGen MS-275
Chemical. CAS 209783-80-2. Formula C21H20N4O3. MW 376.4. HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.
AdipoGen 1-Azakenpaullone
Chemical. CAS 676596-65-9. Formula C15H10BrN3O. MW 328.2. Potent and ATP-competitive GSK-3beta glycogen synthase kinase-3beta inhibitor IC50 = 18 nM.