Thioureas
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
eMolecules 62-56-6 | Thiourea | Chem-Impex | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5kg | 386903164
Thiourea | Chem-Impex | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5kg | 386903164
eMolecules 36822-11-4 | 6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one | MFCD00465574 | 1g
Medchem Express | MEDICA16 | 5mg | 716994246 | HY-P1123 | 87272-20-6 | MFCD00797684 | 342.520 | C20H38O4
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
eMolecules 62-56-6 | Thiourea | Combi-Blocks | MFCD00008067 | 76.120 | CH4N2S | 98.000 | NC(N)=S | 1kg | 335351079
Thiourea | Combi-Blocks | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 98.000 | NC(N)=S | 1kg | 335351079
eMolecules 62-56-6 | Thiourea | Chem-Impex | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 1kg | 112439616
Thiourea | Chem-Impex | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 1kg | 112439616
AdipoGen Vandetanib
Chemical. CAS 443913-73-3. Formula C22H24BrFN4O2. MW 475.4. Vandetanib is an orally available, ATP mimetic small molecule tyrosine kinases inhibitor that targets vascular endothelial growth factor receptor-2 VEGFR-2, VEGFR-3 and epidermal growth factor receptor EGFR, REarranged during Transfection RET and slightly VEGFR-1. Inhibition of these tyrosine kinases blocks multiple intracellular signaling pathways involved in tumor growth, proliferation, progression and angiogenesis. It inhibits RET, VEGFR2, VEGFR3, VEGFR1, EGFR, PDGFRbeta, Tie-2, and FGFR1 in cell-free assays IC50s = 34, 40, 110, 1,600, 500, 1,100, 2,500, and 3,600 nM, respectively. It also binds to 142 additional kinases in a panel of 442 kinases Kds = 4.6-7,900 nM. Vandetanib 1 and 2.5 µM induces apoptosis, autophagy, ROS and cell cycle arrest at the G0/G1 phase and has anti-proliferative properties in several cancer cell lines and in in vivo cancer models.
=S | 500mg | 601600936](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502175443.JPG-250.jpg)
eMolecules 113899-66-4 | Thiourea-13C | Toronto Research Chemicals | MFCD00084092 | 77.110 | CH4N2SN[13C](N)=S | 500mg | 601600936
Thiourea-13C | Toronto Research Chemicals | 113899-66-4 | MFCD00084092 | 77.110 | CH4N2SN[13C](N)=S | 500mg | 601600936
eMolecules 62-56-6 | Thiourea | Oakwood Chemicals | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 1kg | 480131782
Thiourea | Oakwood Chemicals | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 1kg | 480131782
AdipoGen Caroverin
Chemical. CAS 23465-76-1. Formula C22H27N3O2. MW 365.47. Synthetic. Quinoxaline compound, originally developed as a spasmolytic drug. Acts as an N-type calcium channel blocker, competitive AMPA receptor antagonist, and non-competitive NMDA receptor antagonist. Antioxidant agent through partial prevention of the formation and the highly active scavenging of hydroxyl radicals. Used to treat inner ear diseases such as tinnitus. Shown to inhibit tumor-promoting factors and potentially useful as a chemotherapeutic agent.
eMolecules 175205-18-2 | (4-Propylphenyl)thiourea | Oakwood Chemical | MFCD00052484 | 194.300 | C10H14N2S | 95.000 | CCCc1ccc(NC(N)=S)cc1 | 100mg | 537710295
(4-Propylphenyl)thiourea | Oakwood Chemical | 175205-18-2 | MFCD00052484 | 194.300 | C10H14N2S | 95.000 | CCCc1ccc(NC(N)=S)cc1 | 100mg | 537710295
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.
AdipoGen CTPB
Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
AdipoGen Alsterpaullone
Chemical. CAS 237430-03-4. Formula C16H11N3O3. MW 293.3. Potent CDK1/cyclin B IC50 = 35 nM inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E IC50 = 200 nM, CDK5/p25 IC50 = 40 nM, CDK5/p35 IC50 = 40 nM. GSK-3beta glycogen synthase kinase-3beta inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.
AdipoGen Z-Val-Leu-Arg-AMC
Chemical. Formula C35H47N7O7 . C2HF3O2. MW 677.8 . 114.0. Proteasome subunit alpha type-1 Macropain substrate used for assaying the trypsin-like activity of the 20S proteasome. Cysteine proteinase falcipain-2 and falcipain-3 malarial hemoglobinases substrate. Cathepsin S substrate. Hydrolysis of this fluorogenic peptide substrate is monitored by observing fluorescence at an Excitation of 345nm and Emission at 445nm.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.