Anthracyclines
Doxorubicin hydrochloride, MP Biomedicals™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Daunorubicin hydrochloride
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Doxorubicin hydrochloride
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride | 25316-40-9 | MFCD00077757 | 1 mg
Doxorubicin hydrochloride | Purity: 98.0-102.0% | Mol Wt: 579.98 | 25316-40-9 | MFCD00077757 | 1 mg
Medchemexpress LLC Doxorubicin-SMCC 10mM 1mL | 400647-59-8 | 1 ML
Doxorubicin-SMCC is a payload-linker conjugate that links the DNA topoisomerase II inhibitor doxorubicin to a non-cleavable SMCC linker for antibody-drug conjugate research. It is supplied as a 10 mM solution in DMSO.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Non-cleavable SMCC linker for stable maleimide-thiol conjugation.
- Doxorubicin payload (topoisomerase II inhibitor) for potent cytotoxicity.
- High purity (98.8%) for reproducible conjugation and bioassays.
- Molecular weight 762.76 g·mol-1; formula C39H42N2O14.
- Storage: in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Daunorubicin Hydrochloride | 23541-50-6 | 99.7% | 10 MM * 1 ML
Daunorubicin hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. It inhibits DNA and RNA synthesis, acts as a cytotoxin inhibiting cancer cell viability and inducing apoptosis and necrosis. It is also classified as an anthracycline antibiotic. It is utilized in research for infection and various cancers.
- Inhibits DNA and RNA synthesis
- Acts as a cytotoxin to inhibit cancer cell viability
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Used in research for infection and various cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor
Medchemexpress LLC BIIE-0246 | 246146-55-4 | 99.1% | 896.05 g·mol⁻¹ | C49H57N11O6 | 1 ML
BIIE-0246 is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor (NPY2R) used in preclinical neuroscience research. It has an IC50 of approximately 15 nM (rat [125I]PYY3-36) and modulates downstream signaling pathways including p-AKT and p44/42 MAPK. The compound is supplied as a 10 mM solution in DMSO with reported high purity for research use only.
- Potent NPY Y2 receptor antagonist (IC50 ~15 nM).
- Ready-to-use 10 mM solution in DMSO for in vitro assays.
- High reported purity (99.1%).
- Molecular weight 896.05 g·mol⁻¹ and formula C49H57N11O6.
- Suitable for studies of NPY2R signaling and related pathways.
TARGETMOL CHEMICALS INC Doxorubicin hydrochloride
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 uM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy. Purity 99.57%
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mM (in 1mL DMSO)
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 50mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
TARGETMOL CHEMICALS INC DAUNORUBICIN HYDROCHLORI 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Daunorubicin hydrochloride (Rubidomycin hydrochloride) an anthracycline aminoglycoside antineoplastic inhibits DNA replication and repair and RNA and protein synthesis. purity: 99%
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mM (in 1mL DMSO)
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mg
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC Daunorubicin 20830-81-3 50mg
Daunorubicin (20830-81-3) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit this target thereby disrupting nucleic acid synthesis within tumor cells Daunorubicin exerts its biological activity primarily through stabilizing the topoisomerase II-DNA cleavage complex interfering with DNA replication and transcription In in vitro studies daunorubicin demonstrates inhibition of metabolic incorporation of nucleoside precursors into DNA and RNA with reported IC50 values for inhibition of leukemia cell growth ranging from 0 02 1 M depending on cellular context and assay conditions Based on these pharmacological properties daunorubicin holds research potential in oncology studies related to chemotherapy-induced genotoxicity and nucleic acid metabolism
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