Anthracyclines
Daunorubicin Hydrochloride 98.0+%, TCI America™
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Daunorubicin hydrochloride
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Doxorubicin Hydrochloride 95.0+%, TCI America™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Doxorubicin hydrochloride, MP Biomedicals™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Doxorubicin hydrochloride
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 50mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Medchemexpress LLC Daunorubicin (hydrochloride) | 23541-50-6 | 99.7% | 25 MG
Daunorubicin hydrochloride is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic inhibits both DNA and RNA synthesis, functioning as a cytotoxin that reduces cancer cell viability and induces apoptosis and necrosis. It is utilized in research for various infections and cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor. The compound is a pink to red solid, stable under recommended storage conditions, with a melting point of 190°C.
- Target: topoisomerase, DNA/RNA synthesis, ADC payload, bacterial, autophagy, apoptosis, antibiotic
- Research areas: infection, neurological disease, cancer
- CAS number: 23541-50-6
- Molecular formula: C27H30ClNO10
- Molecular weight: 563.98
- Appearance: pink to red solid
- Purity (LCMS): 99.7%
- Melting point: 190°C
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 200 MG
Daunorubicin hydrochloride is a potent topoisomerase II inhibitor and anthracycline antibiotic with significant anti-tumor activity. It inhibits DNA and RNA synthesis, acting as a cytotoxin that reduces cancer cell viability and induces apoptosis and necrosis. It is used in research for various cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor, as well as infection studies.
- Inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.
- Exhibits chemosensitivity in Molt-4 and L3.6 cells.
- Induces apoptosis and necrosis in L3.6 cells.
- Triggers ROS generation in L3.6 cells.
- Induces autophagy in K562 cells.
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 500 MG
Daunorubicin hydrochloride, also known as Daunomycin, is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic functions by inhibiting DNA and RNA synthesis, leading to the suppression of cancer cell viability. It is recognized for its ability to induce apoptosis and necrosis in target cells.
- Potent anti-tumor agent
- Inhibits DNA and RNA synthesis
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Useful in research for various cancers, including leukemia and lymphomas
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mM (in 1mL DMSO)
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Sigma Aldrich Fine Chemicals Biosciences Daunorubicin hydrochloride >=90% (HPLC) | 23541-50-6 | MFCD04974507 | 5MG
Daunorubicin hydrochloride >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 563.98 | 23541-50-6 | MFCD04974507 | 5MG
Medchemexpress LLC Daunorubicin Hydrochloride | 23541-50-6 | 99.7% | 10 MM * 1 ML
Daunorubicin hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. It inhibits DNA and RNA synthesis, acts as a cytotoxin inhibiting cancer cell viability and inducing apoptosis and necrosis. It is also classified as an anthracycline antibiotic. It is utilized in research for infection and various cancers.
- Inhibits DNA and RNA synthesis
- Acts as a cytotoxin to inhibit cancer cell viability
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Used in research for infection and various cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | MFCD04974507 | 99.7% | 563.98 g/mol | C27H30ClNO10 | 5 MG
Daunorubicin hydrochloride is an anthracycline antibiotic and potent cytotoxic research compound that intercalates DNA and inhibits topoisomerase II. Provided as the hydrochloride salt for research use, it is commonly used in oncology and biochemical studies where controlled, small-quantity reagent handling and high-purity material are required.
- Anthracycline antibiotic with cytotoxic activity.
- Potent topoisomerase II inhibitor causing DNA intercalation.
- Hydrochloride salt form for enhanced solubility and handling.
- High purity suitable for analytical and biological assays.
- Molecular weight 563.98 g/mol; formula C27H30ClNO10.
- Supplied in small measured quantities for research workflows.
Medchemexpress LLC Doxorubicin-SMCC 10mM 1mL | 400647-59-8 | 1 ML
Doxorubicin-SMCC is a payload-linker conjugate that links the DNA topoisomerase II inhibitor doxorubicin to a non-cleavable SMCC linker for antibody-drug conjugate research. It is supplied as a 10 mM solution in DMSO.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Non-cleavable SMCC linker for stable maleimide-thiol conjugation.
- Doxorubicin payload (topoisomerase II inhibitor) for potent cytotoxicity.
- High purity (98.8%) for reproducible conjugation and bioassays.
- Molecular weight 762.76 g·mol-1; formula C39H42N2O14.
- Storage: in solvent -80°C (6 months) or -20°C (1 month).
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