Anthracyclines
Doxorubicin hydrochloride
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Doxorubicin hydrochloride, MP Biomedicals™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Daunorubicin hydrochloride
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Doxorubicin Hydrochloride 95.0+%, TCI America™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Daunorubicin Hydrochloride 98.0+%, TCI America™
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Sigma Aldrich Fine Chemicals Biosciences Daunorubicin hydrochloride >=90% (HPLC) | 23541-50-6 | MFCD04974507 | 5MG
Daunorubicin hydrochloride >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 563.98 | 23541-50-6 | MFCD04974507 | 5MG
Selleck Chemical LLC Doxorubicin (DOX) HCl S1208-1g
Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase I and topoisomerase II with IC50s of 0 8 M and 2 67 M respectively Doxorubicin reduces basal phosphorylation of AMPK Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation This product may precipitate when dissolved in PBS solution It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution Doxorubicin (Adriamycin) HCl can be used to induce animal models of kidney disease
Sigma Aldrich Fine Chemicals Biosciences Apoatropine hydrochloride10MG
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity water residual solvents inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH Co. KG
Apexbio Technology LLC Doxorubicin 23214-92-8 25mg
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Medchemexpress LLC Daunorubicin (hydrochloride) | 23541-50-6 | 99.7% | 25 MG
Daunorubicin hydrochloride is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic inhibits both DNA and RNA synthesis, functioning as a cytotoxin that reduces cancer cell viability and induces apoptosis and necrosis. It is utilized in research for various infections and cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor. The compound is a pink to red solid, stable under recommended storage conditions, with a melting point of 190°C.
- Target: topoisomerase, DNA/RNA synthesis, ADC payload, bacterial, autophagy, apoptosis, antibiotic
- Research areas: infection, neurological disease, cancer
- CAS number: 23541-50-6
- Molecular formula: C27H30ClNO10
- Molecular weight: 563.98
- Appearance: pink to red solid
- Purity (LCMS): 99.7%
- Melting point: 190°C
Alkali Scientific Doxorubicin Hydrochloride, Powder, 10 Mg
Doxorubicin Hydrochloride (powder form, 10 mg) is a chemotherapy drug used in the treatment of various cancers such as leukemia, breast cancer, and sarcomas. As a potent anthracycline antibiotic, it interferes with DNA replication and transcription by inserting itself between DNA base pairs, effectively halting cell division. This powder form allows for precise reconstitution, offering flexibility in clinical and research applications. Doxorubicin is crucial in cancer treatment protocols, often used in combination with other drugs to enhance therapeutic outcomes. Its cytotoxic action on cancer cells makes it one of the most widely utilized chemotherapeutic agents in oncological care.
Alkali Scientific Doxorubicin Hydrochloride, Powder, 50 Mg
Doxorubicin Hydrochloride (powder form, 50 mg) is a chemotherapy drug used for the treatment of a wide range of cancers, including breast cancer, leukemia, and lymphomas. The compound works by inhibiting DNA and RNA synthesis, effectively inducing apoptosis in rapidly dividing cells. In powder form, this drug is easy to reconstitute for precise dosing and flexible usage in both clinical and research environments. Doxorubicin is one of the most effective anticancer agents, often used in combination with other chemotherapies to maximize treatment efficacy. It is a key component in various chemotherapy regimens aimed at targeting aggressive and resistant cancer types.