Anthracyclines
Doxorubicin hydrochloride
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Doxorubicin hydrochloride, MP Biomedicals™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Daunorubicin hydrochloride
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Doxorubicin Hydrochloride 95.0+%, TCI America™
CAS: 25316-40-9 Molecular Formula: C27H30ClNO11 Molecular Weight (g/mol): 579.98 MDL Number: MFCD00077757,MFCD00077757,MFCD00941448 InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N Synonym: doxorubicin hydrochloride,adriamycin,doxorubicin hcl,adriacin,adriblastina,rubex,adriamycin hydrochloride,adriblastin,adriamycin pfs PubChem CID: 129626538 IUPAC Name: hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O
Daunorubicin Hydrochloride 98.0+%, TCI America™
CAS: 23541-50-6 Molecular Formula: C27H30ClNO10 Molecular Weight (g/mol): 563.984 MDL Number: MFCD04974507 InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N Synonym: daunorubicin hydrochloride,daunorubicin hcl,daunomycin hydrochloride,daunoblastina,rubidomycin hydrochloride,daunorubicinol hydrochloride,daunoblastin,rubomycin,ondena,daunomycin chlorohydrate PubChem CID: 62770 IUPAC Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
Apexbio Technology LLC BIIE 0246 246146-55-4 1mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior
Apexbio Technology LLC Doxorubicin 23214-92-8 100mg
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mM (in 1mL DMSO)
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC BIIE 0246 246146-55-4 10mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior
Medchemexpress LLC Biie-0246 (AR-H 053591) | 246146-55-4 | 99.1% | 896.05 | C49H57N11O6 | 25 MG
BIIE-0246 is a selective, non-peptide antagonist of the neuropeptide Y Y2 receptor used in pharmacological research. It exhibits potent activity (IC50 ≈ 15 nM) and modulates NPY-mediated signaling pathways, including effects on p-AKT S473 and p44/42 MAPK; it has been used in disease models such as ADR nephropathy.
- High potency at NPY Y2 receptor (IC50 ≈ 15 nM).
- High purity suitable for research applications (99.1%).
- Available as solid and as DMSO solution for flexible dosing.
- Molecular formula C49H57N11O6 and molecular weight 896.05.
- Applicable for in vitro and in vivo studies of NPY signaling and renal pathology.
Medchemexpress LLC BIIE-0246 | 246146-55-4 | 99.1% | 896.05 g/mol | C49H57N11O6 | 10 MG
BIIE-0246 is a non-peptide neuropeptide Y (NPY) Y2 receptor antagonist supplied for laboratory research use. The compound is provided as a high-purity research chemical (CAS 246146-55-4) for in vitro and in vivo pharmacological studies of NPY signaling and receptor pharmacology.
- Potent and selective NPY Y2 receptor antagonist suitable for receptor pharmacology studies.
- High purity (99.10%) appropriate for biochemical and cellular assays.
- Molecular weight 896.05 g/mol, convenient for mass-based preparations.
- Available in small research pack sizes to support pilot and exploratory studies.
- Intended for research use only; not for human or clinical applications.
