Coumarins and derivatives
Medchemexpress LLC 7-Ethoxy-4-methylcoumarin | 87-05-8 | 99.44% | 50 G
7-Ethoxy-4-methylcoumarin is a coumarin derivative that functions as a substrate probe for mammalian cytochromes P450 1A1, 2B4, and 2B6.
- Coumarin derivative
- Substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6
- Molecular weight: 204.22
- Formula: C12H12O3
- Appearance: Solid
- Color: White to off-white
- SMILES: O=C1C=C(C)C2=CC=C(OCC)C=C2O1
Medchemexpress LLC Daphnetin (7,8-dihydroxycoumarin) | 486-35-1 | 99.8% | 178.14 | 5 MG
Daphnetin (7,8-dihydroxycoumarin) is a coumarin derivative found in plants of the Genus Daphne. It is a potent, orally active protein kinase inhibitor.
- Has IC50s of 7.67 μM, 9.33 μM, and 25.01 μM for EGFR, PKA, and PKC in vitro, respectively.
- Triggers ROS-induced cell apoptosis.
- Induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway.
- Possesses anti-inflammatory activity, inhibiting TNF-α, IL-1β, ROS, and MDA production.
- Exhibits schizontocidal activity against malaria parasites.
- Can be utilized in research for rheumatoid arthritis, cancer, and anti-malarial purposes.
Apexbio Technology LLC Palomid 529 914913-88-5 5mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Selleck Chemical LLC Esculetin S4711-100mg
Esculetin (Cichorigenin Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema anti-inflammatory and anti-tumour effects It inhibits lipoxygenases (LOs)
Apexbio Technology LLC 6,7-Dihydroxycoumarin 305-01-1 10mM (in 1mL DMSO)
6 7-Dihydroxycoumarin (CAS 305-01-1) also known as esculetin is a naturally occurring coumarin derivative extracted from Aesculus hippocastanum Linn This compound exhibits notable antioxidant activity primarily by scavenging reactive oxygen species and inhibiting lipid peroxidation Additionally 6 7-dihydroxycoumarin has been studied for its modulatory effects on various cellular signaling pathways implicated in inflammation and apoptosis Its applications in biomedical research include investigations into oxidative stress inflammation and related disease models The compound is soluble in ethanol and dilute alkali and should be stored in a sealed cool and dry environment to preserve stability
Apexbio Technology LLC HX 531 188844-34-0 1mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Medchemexpress LLC Coumarin-C2-exo-BCN | 2488174-17-8 | 95.7% | 479.57 g·mol⁻¹ | C27H33N3O5 | 10 MG
Coumarin-C2-exo-BCN is a coumarin-derived fluorescent dye functionalized with an exo-BCN strained alkyne for bioorthogonal labeling via strain-promoted alkyne-azide cycloaddition (SPAAC). It is intended for catalyst-free conjugation to azide-containing biomolecules to generate fluorescent triazole-linked products.
- Fluorescent coumarin scaffold for sensitive detection.
- exo-BCN strained alkyne enables catalyst-free SPAAC with azides.
- Used to prepare fluorescent conjugates and label azide-containing biomolecules.
- Supplied as a solid with reported purity of ~95.7%.
Chemscene ChemScene | (2R,6S)-rel-tert-Butyl 2,6-diethyl-4-oxopiperidine-1-carboxylate | 5G | CS-W000629 | 0.95 | 1003843-30-8| MFCD12406890 | 255.35
ChemScene | (2R,6S)-rel-tert-Butyl 2,6-diethyl-4-oxopiperidine-1-carboxylate | 5G | CS-W000629 | 0.95 | 1003843-30-8| MFCD12406890 | 255.35
Medchemexpress LLC Coumarin-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 500 G
Coumarin-3-carboxylic acid is an aromatic coumarin derivative (C10H6O4, MW 190.15 g/mol) commonly used as a fluorescence probe for detection of hydroxyl radicals and as a synthetic intermediate in organic and medicinal chemistry. It is supplied in high purity suitable for research and is available in a range of laboratory pack sizes.
- Used as a fluorescence probe for hydroxyl radical detection
- Serves as a synthetic intermediate for coumarin derivatives
- High purity suitable for analytical and research use
- Available in multiple laboratory pack sizes, including bulk options
- Compatible with standard organic solvents for synthesis and analysis
AdipoGen 6 7-Diethoxy-4-CF3 coumarin
Chemical. CAS 351002-66-9. Formula C14H13F3O4. MW 302.25. Synthetic. Fluorescent labelling.
Accela Chembio Inc MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
Medchemexpress LLC Coumarin 6 | 38215-36-0 | 1 ML
Coumarin 6 is a fluorescent dye utilized as a fluorescent probe within microparticle drug delivery systems. It is employed to conduct in vivo tracking, cellular uptake studies, and investigations into the transport mechanisms of drug delivery systems. It has an excitation wavelength (λexc) of 450 nm and an emission wavelength (λem) of 505 nm. This product is intended for research use only and is not sold to patients.
- Used for in vivo tracking, cell uptake, and transport mechanism studies in drug delivery systems
- Optimal wavelengths: Excitation at 450 nm and emission at 505 nm
- Purity: 99.59%
Sigma Aldrich Fine Chemicals Biosciences 4-Methylumbelliferyl phosphate disodium salt | 22919-26-2 | MFCD00037614 | 250 mg
4-Methylumbelliferyl phosphate disodium salt | Mol Wt: 300.11 | 22919-26-2 | MFCD00037614 | 250 mg
