Flavonoids
Apexbio Technology LLC (-)-epicatechin gallate 1257-08-5 20mg
(-)-Epicatechin gallate (ECG) is a catechin compound abundant in green tea displaying bioactivity to modulate cell proliferation apoptosis and gene expression pathways In colon HCT-116 cells ECG induces apoptosis through activating transcription factor 3 (ATF3) regulated via activation of early growth response protein 1 (EGR-1) In these cancer cells ECG upregulates apoptotic factor NAG-1 and increases caspase-3 activity at concentrations around 150 M ECG s cytotoxic potency differs among cell types with an NR50 (midpoint cytotoxic concentration) of approximately 67 M in HSC-2 oral cancer cells while normal human fibroblast HGF-2 cells show greater resistance with an NR50 near 100 M ECG metabolites identified in rat urine include various O-methylated derivatives useful as biomarkers for metabolism studies ECG serves as a research tool for oncology mechanisms and apoptosis signaling pathways
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
Medchemexpress LLC Fustin | 20725-03-5 | 1 MG
Fustin ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. It increases acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). It also decreases acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustin increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. It can be used for Alzheimer's disease research.
- Potent amyloid β (Aβ) inhibitor.
- Increases acetylcholine (ACh) levels and choline acetyltransferase (ChAT) activity.
- Decreases acetylcholinesterase (AChE) activity.
- Enhances muscarinic M1 receptor expression and binding.
- Suitable for Alzheimer's disease research.
Medchemexpress LLC Luteolin-7-rutinoside | 20633-84-5 | 1 MG
Luteolin-7-rutinoside is a flavonoid glycoside exhibiting both anti-arthritic and antifungal activities. It can be used as a combination therapy for the treatment of fungal arthritis due to C. albicans infection. Its suppressive activity is dose-dependent, and it shifts the Th1-Th2 balance away from Th1- towards Th2-type responses, while also inhibiting nitric oxide (NO) production from macrophages.
- Anti-arthritic activity
- Antifungal activity
- Can be used for treatment of fungal arthritis due to C. albicans infection
- Suppressive activity on T cell proliferation is dose-dependent
- Shifts Th1-Th2 balance away from Th1- towards Th2-type responses
- Inhibits nitric oxide (NO) production from macrophages
Apexbio Technology LLC Luteolin 491-70-3 10mM (in 1mL DMSO)
Luteolin (CAS 491-70-3) is a naturally occurring flavonoid characterized by anti-inflammatory antioxidant and chemopreventive properties Mechanistically it suppresses lipopolysaccharide (LPS)-mediated inflammation by inhibiting production of pro-inflammatory cytokines such as TNF- and IL-6 reducing inducible nitric oxide synthesis and blocking NF- B and AP-1 signaling pathways Additionally luteolin impedes TNF- -induced cyclooxygenase-2 (COX-2) expression In preclinical in vivo studies it exhibits antiproliferative activity against tumor cell proliferation exemplified by growth inhibition in Lewis lung carcinoma models Consequently luteolin is widely investigated in biomedical research targeting inflammation oxidative stress and cancer biology
Medchemexpress LLC Luteolin-3-O-beta-D-glucuronide | 53527-42-7 | 25 MG
Luteolin-3-O-beta-D-glucuronide is a flavonoid compound and a metabolite of Luteolin. It is present in Rosmarinus officinalis L. and is for research use only.
- High purity: 99.02%
- Appears as a light yellow to yellow solid
- Classified as a flavonoid compound and metabolite
- Derived from Rosmarinus officinalis L.
Medchemexpress LLC (-)-Epicatechin gallate (Standard) | 1257-08-5 | 97.7% | 442.37 | 50 MG
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. It is also a GLUT1 and GLUT5 inhibitor, and decreases cell growth of GLUT5-expressing hxt0 yeast cells.
- Analytical standard for (-)-Epicatechin gallate.
- Intended for research and analytical applications.
- Inhibits cyclooxygenase-1 (COX-1).
- Acts as a GLUT1 and GLUT5 inhibitor.
- Decreases cell growth of GLUT5-expressing hxt0 yeast cells.
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Cayman Chemical Apigenin Inhibitors
Inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM; potent inhibitor of NO and PGE2 biosynthesis by reducing iNOS and COX-2 expression
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 98.7% | 462.36 | C21H18O12 | 10 MG
Luteolin 7-O-glucuronide is a flavone glycoside used as a research reagent to study matrix metalloproteinase (MMP) inhibition and inflammation-related pathways. It is supplied as a light-yellow solid and as a DMSO solution, and is provided at high purity for biochemical assays and analytical standards.
- Cas number: 29741-10-4.
- Molecular weight: 462.36.
- Typical purity: 98.7% (batch level).
- Physical forms: solid and 10 mM solution in DMSO.
- Typical package sizes include 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
- Common applications: enzymatic inhibition assays and analytical standardization.
Medchemexpress LLC Apigenin (4',5,7-Trihydroxyflavone) | 520-36-5 | 99.2% | 50 MG
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor and inhibits cell proliferation. It suppresses the clone formation of SGC-7901 cells in a dose- and time-dependent manner.
- Competitive CYP2C9 inhibitor
- Inhibits cell proliferation
- Suppresses SGC-7901 cell clone formation
Medchemexpress LLC Apigenin-7-O-(2G-rhamnosyl)gentiobioside | 174284-20-9 | 1 MG
Apigenin-7-O-(2G-rhamnosyl)gentiobioside is a flavone glycoside found in *Lonicera gracilipes* var. *glandulosa*. It has a molecular weight of 740.66 and a molecular formula of C33H40O19. This product is intended for research use only.
- Solid appearance
- Store at 4°C, protected from light
- Soluble in DMSO at 50 mg/mL
Cayman Chemical EpIcatechIn Galate 25mg
A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus
Sigma Aldrich Fine Chemicals Biosciences (−)-Epicatechin | 490-46-0 | MFCD00075648 | 1mg
(−)-Epicatechin | Purity: 98% | MW: 290.27 | 490-46-0 | MFCD00075648 | 1mg
Sigma Aldrich Fine Chemicals Biosciences (−)-Epicatechin | 490-46-0 | MFCD00075648 | 5mg
(−)-Epicatechin | Purity: ≥98% | Mol Wt: 290.27 | 490-46-0 | MFCD00075648 | 5mg