Flavonoids
Apexbio Technology LLC Chrysin 480-40-0 10mM (in 1mL DMSO)
Chrysin a naturally occurring flavonoid compound exhibits antioxidant activity and has been extensively studied in biomedical research contexts Primarily recognized for its capacity to modulate inflammatory signaling pathways and tumor-related cellular processes chrysin specifically acts through the inhibition of hypoxia-inducible factor-1 alpha (HIF-1 ) a critical regulator in cellular response to hypoxia Additionally chrysin promotes cell apoptosis indicating its potential role in antitumor protocols In experimental settings it serves as a biological tool to explore mechanisms underlying inflammation cancer progression and oxidative stress-mediated pathologies
Sigma Aldrich Fine Chemicals Biosciences Epicatechin 90 HPLC5G
Epicatechin is a flavanol. Cacao products are rich in epicatechin.
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Apexbio Technology LLC Rutin 153-18-4 10mM (in 1mL DMSO)
Rutin (CAS 153-18-4) is a naturally occurring flavonoid glycoside that can be isolated from Sophora japonica L It exhibits antioxidant and anti-inflammatory activities primarily by scavenging reactive oxygen species modulating signaling pathways related to oxidative stress and inhibiting pro-inflammatory cytokine production Due to its pharmacological profile rutin is utilized extensively in biomedical research to investigate protective effects against cardiovascular dysfunction vascular permeability and inflammation-related conditions It is soluble in heated water methanol ethanol pyridine and alkaline environments and should be stored under cool dry and sealed conditions
Selleck Chemical LLC Tangeretin 50mg 481-53-8 Tangeritin
Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Luteolin 491-70-3 10mM (in 1mL DMSO)
Luteolin (CAS 491-70-3) is a naturally occurring flavonoid characterized by anti-inflammatory antioxidant and chemopreventive properties Mechanistically it suppresses lipopolysaccharide (LPS)-mediated inflammation by inhibiting production of pro-inflammatory cytokines such as TNF- and IL-6 reducing inducible nitric oxide synthesis and blocking NF- B and AP-1 signaling pathways Additionally luteolin impedes TNF- -induced cyclooxygenase-2 (COX-2) expression In preclinical in vivo studies it exhibits antiproliferative activity against tumor cell proliferation exemplified by growth inhibition in Lewis lung carcinoma models Consequently luteolin is widely investigated in biomedical research targeting inflammation oxidative stress and cancer biology
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC AMG 487 473719-41-4 100mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Cayman Chemical Hesperetin Natural Products Ex
A flavonoid with diverse biological activities; reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells from 10-200 µM; inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml); inhibits LPS-induced NO production and reduces levels of iNOS, IL-6, and IL-1β in BV-2 microglial cells; inhibits passive cutaneous anaphylaxis in mice at 5 mg/kg; reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis; reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation
Cayman Chemical Hesperetin Natural Products Ex
A flavonoid with diverse biological activities; reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells from 10-200 µM; inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml); inhibits LPS-induced NO production and reduces levels of iNOS, IL-6, and IL-1β in BV-2 microglial cells; inhibits passive cutaneous anaphylaxis in mice at 5 mg/kg; reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis; reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation
eMolecules Medchem Express / Kaempferol 374-trimethyl ether / 1mg / 533803594 / HY-N3434 / / 15486-34-7 / MFCD00017439 / 328.320 / C18H16O6
Medchem Express / Kaempferol 374-trimethyl ether / 1mg / 533803594 / HY-N3434 / / 15486-34-7 / MFCD00017439 / 328.320 / C18H16O6
Apexbio Technology LLC (±)-AMG 487 50mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies
Medchemexpress LLC Acacetin-7-O-β-D-galactopyranoside | 80443-15-8 | 98.6% | 446.40 | C22H22O10 | 5mg
Acacetin-7-O- -D-galactopyranoside is a flavonoid that can be isolated from flower heads of Chrysanthemum morifolium Acacetin-7-O- -D-galactopyranoside inhibits AChE activity and can be used for research of Alzheimer s disease[1]
Selleck Chemical LLC Nobiletin S2333-10mM/1mL
Nobiletin a citrus flavonoid isolated from citrus peels like in tangerine which has anti-inflammatory and anti-tumor activities