Flavonoids
Medchemexpress LLC 5-Hydroxyflavone | 491-78-1 | 99.8% | 238.24 | 100 MG
5-Hydroxyflavone | 491-78-1 | 99.8% | 238.24 | 100 MG
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mg
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
Apexbio Technology LLC Chrysin 480-40-0 10mM (in 1mL DMSO)
Chrysin a naturally occurring flavonoid compound exhibits antioxidant activity and has been extensively studied in biomedical research contexts Primarily recognized for its capacity to modulate inflammatory signaling pathways and tumor-related cellular processes chrysin specifically acts through the inhibition of hypoxia-inducible factor-1 alpha (HIF-1 ) a critical regulator in cellular response to hypoxia Additionally chrysin promotes cell apoptosis indicating its potential role in antitumor protocols In experimental settings it serves as a biological tool to explore mechanisms underlying inflammation cancer progression and oxidative stress-mediated pathologies
Apexbio Technology LLC (-)-epicatechin 490-46-0 5mg
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations
TARGETMOL CHEMICALS INC PINOCEMBRIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pinocembrin (57-Dihydroxyflavanone) is a flavanone a type of flavonoid. It is an antioxidant found in damiana honey fingerroot and propolis. purity: 98%
Medchemexpress LLC (±)-Catechin | 7295-85-4 | 99.5% | 100 MG
(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. It has two forms, (+)-Catechin and its enantiomer (-)-Catechin, each with distinct biological activities. The racemate exhibits anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects.
- Racemate of green tea polyphenol Catechin.
- Has anticancer activity and induces apoptosis.
- (+)-Catechin form inhibits cyclooxygenase-1 (COX-1).
- (-)-Catechin form promotes hBM-MSC adipocyte differentiation.
- Possesses anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective, and neuroprotective effects.
- Appearance: Solid, White to off-white.
- Solubility: In Vitro: DMSO : 100 mg/mL.
Apexbio Technology LLC (-)-Epigallocatechin gallate (EGCG) 989-51-5 500mg
(-)-Epigallocatechin gallate (EGCG CAS 989-51-5) is a major catechin component derived from green tea comprising approximately 59% of total catechins EGCG exhibits antioxidant antiangiogenic antitumor and antiviral properties by modulating cellular signaling pathways involved in apoptosis induction cell cycle arrest and tumorigenesis inhibition It suppresses viral replication in pathogens including HCV HIV-1 HBV HSV-1/2 EBV adenovirus influenza virus and enterovirus and inhibits enzyme targets such as DNA methyltransferases (DNMTs) proteases and DHFR EGCG is utilized widely in biomedical research examining chemoprevention mechanisms and therapeutic potential in cancers such as hepatic gastric dermal pulmonary breast and colorectal malignancies
Apexbio Technology LLC Rutin 153-18-4 10mM (in 1mL DMSO)
Rutin (CAS 153-18-4) is a naturally occurring flavonoid glycoside that can be isolated from Sophora japonica L It exhibits antioxidant and anti-inflammatory activities primarily by scavenging reactive oxygen species modulating signaling pathways related to oxidative stress and inhibiting pro-inflammatory cytokine production Due to its pharmacological profile rutin is utilized extensively in biomedical research to investigate protective effects against cardiovascular dysfunction vascular permeability and inflammation-related conditions It is soluble in heated water methanol ethanol pyridine and alkaline environments and should be stored under cool dry and sealed conditions
Indofine Chemical Kaempferol, 99%, 100 Mg
KAEMPFEROL 100 MG, Flavone, 3,5,7,4'-Tetrahydroxyflavone; Robigenin, C15H10O6, MW: 286.24, 0.99, 520-18-3, MFCD00016938
AdipoGen Luteolin
Chemical. CAS 491-70-3. Formula C15H10O6. MW 286.2. Synthetic. Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase 15-LOX inhibitor. IL-6 production inhibitor. Fatty acid synthase FAS inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-gamma inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 PDE1-5. PKCepsilon and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator Phosphatidylinositol 3-kinase PI3K / Akt signaling inhibitor. p90 ribosomal S6 kinase RSK1/RSK2 kinase activity inhibitor.
Medchemexpress LLC (±)-Catechin | 7295-85-4 | 99.5% | 250 MG
(±)-Catechin | 7295-85-4 | 99.5% | 250 MG