Flavonoids
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 g/mol | C15H12O3 | 1 G
3'-Hydroxyflavanone is a cyclized flavanone (C15H12O3) reported to induce apoptosis in HeLa cells and to possess antitumor activity in cellular studies. It is employed in biochemical and pharmacological research to probe apoptosis pathways and to study flavonoid bioactivity.
- Cyclized flavanone scaffold with a 3'-hydroxy substitution.
- Reported to induce apoptosis in HeLa cells.
- Demonstrated antitumor activity in preclinical cellular studies.
- Useful as a biochemical probe for apoptosis-related pathways.
- Supplied as a solid with defined molecular formula and molecular weight.
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 10 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis* with anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity via the ERK/Nrf2/HO-1 pathway. This compound inhibits PKM2 with an IC50 of 2.12 μM and also inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL, respectively. 7-Hydroxyflavone is orally active.
- Isolated from *Clerodendrum phlomidis*.
- Exhibits anti-inflammatory activity.
- Protects renal cells from nicotine-associated cytotoxicity.
- Inhibits PKM2, COX-2, and 5-LOX.
- Orally active.
- Inhibits EV71 3C protease and viral replication.
- Antioxidant properties: decreases MDA and ROS, increases SOD and GSH.
- Ameliorates ischemia/reperfusion injury and neuropathic pain.
- Improves hepatic steatosis and regulates blood glucose metabolism in NAFLD models.
Medchemexpress LLC 4'-hydroxyflavone | 4143-63-9 | MFCD00017687 | 97.0% | 238.24 g/mol | C15H10O3 | 5 MG
4'-Hydroxyflavone is a small-molecule flavone provided for research use. It has the chemical formula C15H10O3, a molecular weight of 238.24 g/mol, and is reported to inhibit aldose reductase (IC50 = 12 μM). The material is intended as a reference reagent for biochemical, pharmacological, and enzymology studies.
- High purity (97.0%) suitable for analytical and biological assays.
- Reported aldose reductase inhibitor (IC50 = 12 μM) for target validation studies.
- Well-characterized chemical identity and molecular properties.
- Available in small pack sizes appropriate for research applications.
- Suitable for biochemical assays, enzymology, and screening workflows.
Medchemexpress LLC 3'-hydroxyflavanone | 92496-65-6 | MFCD00017738 | >98.0% | 240.25 | C15H12O3 | 100 MG
3′-Hydroxyflavanone is a cyclized flavanone research compound reported to induce apoptosis in HeLa cells and to possess antitumor activity. It is intended for in vitro biochemical and cellular studies and is supplied with an accompanying datasheet for characterization and safety information.
- Cyclized flavanone structure suitable for flavonoid research.
- Reported to induce apoptosis in HeLa cells.
- Reported antitumor activity in literature.
- Available in multiple pack sizes from milligram to gram quantities.
- Supplied in high-purity grades with supporting datasheet.
Medchemexpress LLC Catechin 7-O-β-d-glucopyranoside | 65597-47-9 | 99.5% | 452.41 g/mol | C21H24O11 | 10 MG
Catechin 7-O-β-D-glucopyranoside is a flavonoid glycoside used in research for its antioxidant and anti-inflammatory properties. Supplied as a white to off-white solid with high reported purity, it is suitable for in vitro and in vivo studies and has documented uses at 10 μg/mL (in vitro) and 10 mg/kg (in vivo).
- Appearance: White to off-white solid.
- Purity: 99.5% (reported).
- Molecular weight: 452.41 g/mol.
- Solubility: DMSO 125 mg/mL (requires ultrasonic).
- Storage: 4°C, protect from light; in solution -80°C (6 months) or -20°C (1 month).
- Typical uses: Antioxidant and anti-inflammatory assays in cells and animal models.
Medchemexpress LLC Catechin-13C3 | 154-23-4 | MFCD15144883 | 293.25 | 1 MG
Catechin-13C3 is a 13C-labeled version of Catechin, a natural antioxidant found in various plants. This compound inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. This stable isotope-labeled compound is valuable for research applications.
- Labeled stable isotope
- Useful for metabolic studies
- Ideal for quantitative analysis
- Suitable for tracking biochemical pathways
TARGETMOL CHEMICALS INC TYPHANEOSIDE 25MG
Also available in 5 mg 10 mg 50 mg and bulk. Please contact Fisher for quotes. Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction. purity: 99%
Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 1 MG
Luteolin 7-O-glucuronide inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, and 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It also inhibits NO production and mRNA expression of inflammatory mediators (COX-2, IL-6, IL-1β, and TNF-α) as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In a mouse sleep deprivation model, this compound improved depression-like and stress coping behaviors.
- Inhibits matrix metalloproteinases (MMPs) activities.
- Reduces NO production and inflammatory mediators.
- Inhibits NF-κB, p38, and JNK activation.
- Improves depression-like and stress coping behaviors.
- Suitable for in vitro and in vivo studies.
Indofine Chemical Fisetin, 98%, 500 Mg
Molecular Formula: C15H10O6, Purity: 98%, Molecular Weight: 286.25, Appearance: Light yellow powder, Solubility: Soluble in DMSO, Storage conditions: Store in a cool, dry place, Also known as 3,7,3',4'-Tetrahydroxyflavone
Apexbio Technology LLC AMG 487 473719-41-4 50mg
AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research
Apexbio Technology LLC (-)-epicatechin 490-46-0 10mg
(-)-Epicatechin (CAS 490-46-0) is a flavonoid compound known for inducing pancreatic -cell regeneration and modulating nitric oxide (NO) metabolism It inhibits nitric oxide-related nitrite formation induced by interferon- and lipopolysaccharide in mouse macrophages and reduces peroxynitrite-mediated tyrosine nitration in HL-60 human leukemia cells Additionally in human endothelial cells (HUVECs) it enhances NO production displaying vasodilatory properties In diabetic rat models (alloxan-induced) (-)-epicatechin administration promotes -cell recovery reduces hyperglycemia and prevents -cell necrosis This profile underscores its research relevance for diabetes and vascular biology investigations