Flavonoids
Medchemexpress LLC 7,8-Dihydroxyflavone | 38183-03-8 | 254.24 | 25 MG
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). It displays therapeutic efficacy toward various neurological diseases.
- Protects primary cortical neurons and locus coeruleus neurons from Aβ-induced toxicity
- Promotes dendritic growth and synaptogenesis
- Prevents synaptic loss and memory deficits in an Alzheimer's Disease model
- Activates TrkB in the brain
- Inhibits kainic acid-induced toxicity
- Decreases infarct volumes in stroke
- Neuroprotective in a Parkinson disease model
Medchemexpress LLC HY-N2609 50mg Medchemexpress, 7,4'-Dihydroxyflavone CAS:2196-14-7 Purity:>98%
Medchemexpress, HY-N2609 50mg 7,4'-Dihydroxyflavone CAS:2196-14-7 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 50mg
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 10mg
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies
Medchemexpress LLC 3,6-Dihydroxyflavone | 108238-41-1 | 25 MG
3,6-Dihydroxyflavone is an anti-cancer agent that decreases cell viability and induces apoptosis. It works by activating the caspase cascade and cleaving poly (ADP-ribose) polymerase (PARP). Additionally, it increases intracellular oxidative stress and lipid peroxidation.
- Decreases cell viability and induces apoptosis
- Activates caspase cascade
- Cleaves poly (ADP-ribose) polymerase (PARP)
- Increases intracellular oxidative stress
- Increases lipid peroxidation
- Appears as a light yellow to light brown solid
- Has a molecular weight of 254.24
- Chemical formula is C15H10O4
- Purity is 98.06%
- Soluble in DMSO at 66.67 mg/mL
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 10mM (in 1mL DMSO)
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies
Medchemexpress LLC 3,6-Dihydroxyflavone | 108238-41-1 | 10 MG
3,6-Dihydroxyflavone is an anti-cancer agent that dose- and time-dependently decreases cell viability and induces apoptosis by activating the caspase cascade and cleaving poly (ADP-ribose) polymerase (PARP). It also increases intracellular oxidative stress and lipid peroxidation.
- Anti-cancer agent
- Decreases cell viability
- Induces apoptosis by activating caspase cascade
- Cleaves poly (ADP-ribose) polymerase (PARP)
- Increases intracellular oxidative stress
- Increases lipid peroxidation
eMolecules 2196-14-7 | 7,4'-Dihydroxyflavone | MFCD00017694 | 1g
Ambeed | Naphthalen-1-ylmethanol | 25g | 525096950 | A179694 | 4780-79-4 | MFCD00004044 | 158.200 | C11H10O
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Medchemexpress LLC Apigenin 7-O-malonylglucoside | 86546-87-4 | 5 MG
Apigenin 7-O-malonylglucoside is a compound found in chrysanthemum flowers. This product is intended for research use only and is not for human use or medical applications.
- White to off-white solid appearance
- Purity of 97.29%
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light
- Soluble in DMSO at 50 mg/mL (96.45 mM) with ultrasonic required
Cayman Chemical LuteolIn 7-O-GlucuronIde 1mg
A flavonoid with antioxidant, enzyme inhibitory, and anti-inflammatory properties; scavenges DPPH radicals in a cell-free assay (IC50 = 80.6 μM); inhibits porcine α-amylase and yeast α-glucosidase in vitro (IC50s = 61.5 and 14.7 μM, respectively); inhibits rat aldose reductase in vitro (IC50 = 0.7 μM) and sorbitol accumulation in isolated rat lens at 5 μg/ml; inhibits LPS-induced cytokine release from RAW 264.7 macrophages in a dose-dependent manner
Medchemexpress LLC Luteolin 5-O-glucoside | 20344-46-1 | 448.38 | 1 MG
Luteolin 5-O-glucoside is a major flavonoid extracted from *Cirsium maackii*. It exhibits anti-inflammatory properties by inhibiting LPS-induced NO production and t-BHP-induced ROS generation. This compound also suppresses the expression of iNOS and COX-2 in macrophages, making it suitable for various research applications focusing on inflammation pathways.
- Inhibits LPS-induced NO production.
- Suppresses t-BHP-induced ROS generation.
- Reduces expression of iNOS and COX-2 in macrophages.
- Derived from natural plant sources.