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Flavonoids

Polyphenolic organic compounds that have 15 carbons with the general structure of two phenyl rings and a heterocyclic ring, or a ring with two or more atoms. Flavonoids are a class of polyphenolic plant and fungus secondary metabolites.

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1

Selleck Chemical LLC Luteolin S2320-10mM/1mL

Luteolin (Luteoline Luteolol Digitoflavone) is a flavonoid found in Terminalia chebula which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15 0 M 6 4 M 13 9 M 11 1 M and 9 5 M respectively

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2

Selleck Chemical LLC Luteolin S2320-1g

Luteolin (Luteoline Luteolol Digitoflavone) is a flavonoid found in Terminalia chebula which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15 0 M 6 4 M 13 9 M 11 1 M and 9 5 M respectively

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3

TARGETMOL CHEMICALS INC APIGENIN-7-GLUCURONIDE 5MG
SDP

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s 12.87 22.39 17.52 0.27 uM for MMP-3 MMP-8 MMP-9 MMP-13 respectively). purity: 99%

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4

Medchemexpress LLC Apigenin 7-O-glucuronide | 29741-09-1 | MFCD23699539 | >95.0% | 10 MG
SDP

Apigenin 7-O-glucuronide is a flavonoid glucuronide supplied as an analytical standard for research and analytical applications. It has reported inhibitory activity against matrix metalloproteinases, with IC50s of 12.87 μM (MMP-3), 22.39 μM (MMP-8), 17.52 μM (MMP-9), and 0.27 μM (MMP-13). CAS: 29741-09-1; molecular weight: 446.36 g/mol.

  • Provided as a 10 mg analytical standard for research use only.
  • Reported inhibitory activity against multiple MMP enzymes with published IC50 values.
  • Chemical formula C21H18O11 and molecular weight 446.36 g/mol.
  • Commonly used in biochemical and analytical assays to characterize apigenin metabolites.

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5

Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 1 ML
SDP

Luteolin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, and 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It is intended for research use only.

  • Inhibits NO production and mRNA expression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.
  • Inhibits NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages.
  • Improves depression-like and stress coping behaviors in mouse sleep deprivation models.
  • Reduces increased immobility time and plasma corticosterone levels.
  • Reduces TNF-α and IL-1β levels and increases BDNF mRNA expression in the hippocampus of sleep-deprived mice.

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6

Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 1 MG
SDP

Luteolin 7-O-glucuronide inhibits Matrix Metalloproteinases (MMP) activities, with IC50s of 17.63, 7.99, 11.42, 12.85, and 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13, respectively. It also inhibits NO production and mRNA expression of inflammatory mediators (COX-2, IL-6, IL-1β, and TNF-α) as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In a mouse sleep deprivation model, this compound improved depression-like and stress coping behaviors.

  • Inhibits matrix metalloproteinases (MMPs) activities.
  • Reduces NO production and inflammatory mediators.
  • Inhibits NF-κB, p38, and JNK activation.
  • Improves depression-like and stress coping behaviors.
  • Suitable for in vitro and in vivo studies.

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7

Medchemexpress LLC Luteolin 7-O-glucuronide | 29741-10-4 | 462.36 | 5 MG
SDP

Luteolin 7-O-glucuronide is a compound that inhibits Matrix Metalloproteinases (MMP) activities, with specific IC50 values for MMP-1, MMP-3, MMP-8, MMP-9, and MMP-13. It also demonstrates biological activity by inhibiting NO production and the mRNA expression of various inflammatory mediators, as well as NF-κB, p38, and JNK activation in LPS-stimulated RAW 264.7 macrophages. In vivo studies suggest it can improve depression-like and stress coping behaviors in sleep-deprived mice models.

  • Inhibits matrix metalloproteinases (MMPs) activities
  • Inhibits NO production in LPS-stimulated RAW 264.7 macrophages
  • Reduces mRNA expression of inflammatory mediators
  • Suppresses NF-κB, p38, and JNK activation
  • Improves depression-like and stress coping behaviors in sleep deprivation models
  • Decreases immobility time and plasma corticosterone levels
  • Enhances BDNF mRNA expression in the hippocampus

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