Flavonoids

Cayman Chemical ApIgenIn 7OGlucuronIdehyd 10mg

An FPR2 agonist induces calcium flux in CHO cells expressing human FPR2 and Ga16 (EC50 a16 alone or in combination with FPR1 (EC50s 10000 nM for both) induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner increases production of IL-1B and IL-6 in isolated human monocytes at 10 UM

Apexbio Technology LLC AMG 487 473719-41-4 50mg

AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research

Apexbio Technology LLC AMG 487 473719-41-4 100mg

AMG 487 (CAS 473719-41-4) is a selective small molecule antagonist targeting chemokine receptor CXCR3 a G protein-coupled receptor involved in immune cell migration It competitively inhibits CXCR3 binding to its cognate chemokines including IP-10 and ITAC with IC50 values reported at approximately 8 nM and 8 2 nM respectively Cell-based assays indicate AMG 487 can effectively impede IP-10 ITAC and MIG-mediated chemotaxis and ITAC-induced calcium mobilization AMG 487 is metabolized via CYP3A4 and CYP3A5 to metabolites one of which (M2) inhibits CYP3A Given these characteristics AMG 487 provides a valuable pharmacological tool for investigating CXCR3 functions in inflammatory and immunological research