Linear 1 3-diarylpropanoids
Medchemexpress LLC Brepocitinib (P-tosylate) | 2140301-96-6 | 100.0% | 561.60 | 1 ML
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor. It inhibits JAK1 with an IC50 of 17 nM and TYK2 with an IC50 of 23 nM. It also inhibits JAK2 with an IC50 of 77 nM and JAK3 with an IC50 of 6.49 μM. This compound demonstrates in vitro efficacy in inhibiting various STAT pathways and in vivo efficacy by reducing paw volume in an arthritis model.
- Potent dual inhibitor of JAK1 and TYK2
- Specific inhibition of JAK2 and JAK3 at higher concentrations
- In vitro efficacy in inhibiting STAT pathways
- In vivo efficacy in an animal model of arthritis
- Solid, white to off-white color
- Intended for research purposes only
Medchemexpress LLC Isodecyl diphenyl phosphate | 29761-21-5 | MFCD00072254 | 390.45 | C22H31O4P | 5mg
Isodecyl diphenyl phosphate (IDPP) is a flame retardant IDPP has an ability to induce DNA damage and exertes S phase cell ratio-reducing effects in A549 cells[1]
Selleck Chemical LLC Naringenin S2394-25mg
Naringenin (NSC 34875 S-Dihydrogenistein NSC 11855 Salipurol) is a natural predominant flavanone derived from plant food which is considered to have a bioactive effect on human health as antioxidant free radical scavenger anti-inflammatory carbohydrate metabolism promoter and immune system modulator
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 5 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent. It also possesses antioxidant and anti-inflammatory activities, and can improve adipocyte functions. It inhibits histamine release from rat peritoneal mast cells.
- Anti-allergic agent: Inhibits histamine release from mast cells and reduces ear-swelling in allergic mice.
- Antioxidant activity: Demonstrated antioxidant properties.
- Anti-inflammatory activity: Inhibits production of TNF-alpha, MCP-1, and nitric oxide by LPS-stimulated macrophages.
- Adipocyte function improvement: Enhances adiponectin production and stimulates PPARγ activity.
- High purity: 98.87%.
- Appearance: Solid, light yellow to yellow.
- Molecular weight: 272.26.
- Chemical formula: C15H12O5.
- Initial source: Plants (Solanaceae, *Solanum lycopersicum L.*).
Medchemexpress LLC 2-propen-1-one, 1,3-diphenyl- | 94-41-7 | 100.0% | 1 ML
Chalcone (2-Propen-1-one, 1,3-diphenyl-) is an α,β-unsaturated ketone used as a synthetic building block and research reagent. It is supplied as a solid or as a prepared 10 mM solution in DMSO, 1 ML, for screening and synthesis applications.
- Offered as solid and as 10 mM solution in DMSO, 1 ML.
- High purity (99.98% by HPLC) suitable for research use.
- Commonly used for synthesis of chalcone derivatives and biological screening.
- Provided with certificate of analysis documenting identity and purity.
Medchemexpress LLC (E)-Naringenin chalcone | 25515-46-2 | 25 MG
(E)-Naringenin chalcone is an orally active anti-allergic agent that exhibits antioxidant and anti-inflammatory properties. It can enhance adipocyte functions and inhibits the release of histamine from rat peritoneal mast cells.
- Anti-allergic agent: orally active and inhibits histamine release from rat peritoneal mast cells.
- Antioxidant activity: possesses antioxidant properties.
- Anti-inflammatory activity: demonstrates anti-inflammatory effects.
- Adipocyte function improvement: can improve the functions of adipocytes.
- PPARγ stimulation: stimulates the activity of PPARγ in NIH-3T3 cells.
- Inhibition of inflammatory mediators: inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages.
- Suppresses allergic asthma: inhibits the type-2 function of CD4 T cells in allergic airway inflammatory mice.
Medchemexpress LLC Naringenin trimethyl ether | 38302-15-7 | 1 MG
Naringenin trimethyl ether is a constituent of twigs and leaves of Aglaia duperreana. It is known for its significant molluscicidal activity, demonstrating an LC50 of 3.9 μg/mL for P. canaliculata. This compound is intended for research use only.
- Constituent of twigs and leaves of Aglaia duperreana
- Exhibits significant molluscicidal activity
- LC50 of 3.9 μg/mL for P. canaliculata
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.64% | C23H23N5O4S | 1 ML
PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor with IC50 values of 6.99 μM for PI3Kγ, 4.01 μM for PI3Kδ, and 3.36 μM for AKT. It exhibits anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3 dependent apoptosis.
- Effective dual inhibitor of PI3K/AKT
- Exhibits anticancer activity
- Inhibits PI3K/AKT axis
- Induces caspase 3 dependent apoptosis
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 100 G
This product, 4'-Methoxychalcone, regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.
- Regulates adipocyte differentiation
- Activates PPARγ
- Modulates adipokine expression related to insulin sensitivity
- Stable under recommended storage conditions
- White to light yellow solid appearance
- High purity of 99.8%