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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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Hydroquinone diacetate is an acetylated derivative of hydroquinone used as an intermediate in organic and medicinal chemistry. It is supplied as a solid powder for research applications and may be provided as a solution in DMSO for screening or formulation work.
White to off-white solid powder.
Molecular weight 194.19 g/mol.
Purity about 98.3% by GC.
Recommended storage: powder at -20°C or 4°C depending on shelf life.
Common uses include organic synthesis intermediates and skin-lightening research.
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JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) is the hydrochloride salt of a small-molecule kinase inhibitor selective for MELK and active against FLT3. It is used as a research reagent to probe MELK biology and to evaluate antiproliferative effects in cellular assays.
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p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). It participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reactions. It also promotes the shedding of betacellulin precursor (pro-BTC) and influences the binding of agonists and antagonists to the opiate receptor.
Organomercurial activator of matrix metalloproteinases (MMP)
Activates MMP-2 and MMP-9 at 0.5 mM for 30 minutes
Decreases the apparent number of dihydromorphine binding sites and increases the sensitivity of agonist binding to the inhibitory effects of sodium in rat brain homogenate at 0-30 μM for 20 minutes
Promotes the shedding of betacellulin precursor (pro-BTC)
Influences the binding of agonists and antagonists to the opiate receptor
Participates in the activation and inhibition of MMP-8
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Acridone is an organic compound based on the acridine skeleton. It possesses antibacterial, antimalarial, antiviral, and antineoplastic activities.
Exhibits antibacterial, antimalarial, antiviral, and antineoplastic activities.
Inhibits the proliferation of MDA-MB-231 cancer cells (0.1-1 μM, 48 h) and blocks the mRNA and protein expression of ATP binding cassette subfamily G member 2 (ABCG2).
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Cefotaxime sodium is a β-lactamase stable, third-generation cephalosporin antibiotic. It demonstrates broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
Exhibits MIC of 0.0625 mg/L for V. vulnificus CMCP6
More effective in clearing V. vulnificus in vivo when combined with ciprofloxacin
Lowers viable bacterial counts in liver when combined with ciprofloxacin
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Tolazoline hydrochloride (CAS 59-97-2) is a small molecule that functions as a competitive antagonist at -adrenergic receptors exhibiting non-selective affinity for both 1- and 2-adrenoceptor subtypes By inhibiting endogenous catecholamine binding tolazoline modulates vasomotor tone and vascular smooth muscle contraction This pharmacological profile enables researchers to investigate adrenergic signaling pathways and the physiological roles of -adrenergic receptors Tolazoline HCl is widely utilized in studies of vascular function receptor pharmacology and the characterization of sympathetic nervous system mechanisms
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V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5), but not ASCT1. It inhibits ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells.
Inhibits ASCT2-mediated glutamine uptake in human cells.
Shows improved potency over gamma-L-glutamyl-p-nitroanilide.
Attenuates cancer cell growth and proliferation.
Increases cell death and oxidative stress.
Prevents tumor growth in xenograft models.
Elicits strong growth inhibition in xenograft models when combined with CB-839.
Reduces tumor growth.
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