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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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Phenylhydroquinone is a small-molecule research reagent reported to induce thymic atrophy and to up-regulate apoptosis through activation of p53. It is used in biochemical and cell-based studies to probe MDM2/p53, ERK, and p38 MAPK signaling pathways.
Induces thymic atrophy and modulates apoptosis pathways.
Reported activity against MDM2/p53, ERK, and p38 MAPK.
High reported purity suitable for research use.
Available in multiple package sizes, including 100 g.
Molecular formula C12H10O2 and molecular weight 186.21.
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Phenylhydroquinone (2-phenylhydroquinone; CAS 1079-21-6) is a small-molecule research reagent that induces thymic atrophy and up-regulates apoptosis via p53 activation. It is supplied as a high-purity solid for use in in vitro and in vivo studies of apoptosis, thymic function, and related signaling pathways.
Orally active thymic atrophy inducer.
Modulates apoptosis through p53 activation.
High purity suitable for biological research.
Available in small-scale quantities for laboratory studies.
Chemically characterized: C12H10O2; MW 186.21.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Phenylhydroquinone (PHQ) is a small-molecule research reagent reported to induce thymic atrophy and to up-regulate apoptosis through activation of p53. In cellular studies PHQ activates p53 via phosphorylation of Erk1/2 and p38 (example: 10 μM, 3 h in mouse thymocytes). It is supplied as a high-purity chemical for laboratory research.
Induces thymic atrophy and promotes apoptosis via p53 activation.
Activates p53 through phosphorylation of Erk1/2 and p38 in vitro.
High purity (99.21%) suitable for research applications.
Molecular weight 186.21 g/mol; formula C12H10O2.
Available in multiple laboratory pack sizes for experimental use.
Supplied with a certificate of analysis documenting purity.
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Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM for ovine COX-1 and 52.2 μM for human recombinant COX-2. It has potential DNA damaging effects by inhibiting COX-1 to reduce prostaglandin synthesis and induce anti-inflammatory activity, and by inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions.
Orally active COX inhibitor
IC50s of 480.7 μM for ovine COX-1 and 52.2 μM for human recombinant COX-2
Potential DNA damaging effects, including inducing DNA single-strand breaks
Exerts effects by competitively binding to active sites of COX-1 and non-covalent interactions
Induces DNA single-strand breaks and increases ornithine deoxycholate (ODC) activity and repetitive DNA synthesis (RDS) in rat gastric pyloric mucosa
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Phenylhydroquinone (2-Phenylhydroquinone) is a small-molecule research reagent reported to induce thymic atrophy and to up-regulate apoptosis via p53 activation. It is used in studies of apoptosis-related signaling and thymic atrophy mechanisms, with reported activity involving MDM2/p53, ERK, and p38 MAPK pathways.
Orally active thymic atrophy inducer suitable for in vivo and in vitro research.
Up-regulates apoptosis through activation of p53.
Engages MDM2/p53, ERK, and p38 MAPK pathways relevant to apoptosis studies.
High purity (99.21%) appropriate for experimental applications.
Chemical formula C12H10O2; molecular weight 186.21 g·mol⁻¹; CAS 1079-21-6.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More