N-(p-Coumaroyl) Serotonin is a selective inhibitor of PDGFRβ, ERK1/2, and caspase-8, exhibiting antioxidant, anti-atherosclerotic, and anti-inflammatory properties. It inhibits glioblastoma cells and demonstrates anti-inflammatory activity in RAW264.7 cells. The compound works by inhibiting PDGF signaling, blocking Ca2+ influx, and inducing apoptosis, making it suitable for glioblastoma and atherosclerosis research.
- Selective inhibitor of PDGFRβ, ERK1/2, and caspase-8
- Possesses antioxidant, anti-atherosclerotic, and anti-inflammatory properties
- Inhibits glioblastoma cells
- Reduces PDGF signaling and blocks Ca2+ influx
- Induces apoptosis through caspase-8 activation
- Improves atherosclerosis and aortic wall enlargement