Phenols
Apexbio Technology LLC CPI-455 HCl 2095432-28-1 5mg
CPI-455 HCl (CAS 2095432-28-1) is a potent inhibitor of the KDM5 family of histone demethylases which regulate demethylation of histone H3 lysine 4 (H3K4) CPI-455 exhibits an IC50 of 10 nM for KDM5A in enzymatic assays and displays comparable inhibitory activity against KDM5B and KDM5C but markedly reduced potency for KDM4C and KDM7B and negligible activity towards other KDM family members In vitro CPI-455 treatment leads to a dose-dependent increase in global H3K4me3 levels in HeLa cells with rapid reversal upon compound removal This compound is used in research to probe the role of KDM5-mediated histone modifications and the survival mechanisms of drug-tolerant cancer cell populations
Medchemexpress LLC Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate | 64987-85-5 | MFCD00009634 | 99.6% | 334.32 g/mol | C16H18N2O6 | 100 G
Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is a heterobifunctional, non-cleavable crosslinker that couples primary amines to sulfhydryl groups via NHS-ester and maleimide chemistry. It is used to prepare stable protein-protein and protein-small molecule conjugates for applications such as antibody-drug conjugates and antigen conjugates for immunization.
- Heterobifunctional, non-cleavable crosslinker
- Reacts with primary amines (NHS ester) and sulfhydryls (maleimide)
- Used for protein conjugation and antibody-drug conjugate synthesis
- High purity suitable for research applications
- Store sealed, protect from moisture and light; recommended cold storage
Medchemexpress LLC 2(1H)-pyrimidinone, tetrahydro-1,3-dimethyl- | 7226-23-5 | MFCD00006550 | 99.9% | 128.17 g/mol | C6H12N2O | 100g
N N -Dimethyltrimethyleneurea is an intermediate N N -Dimethyltrimethyleneurea can be used in the preparation of naphthalocyanine compounds (near-infrared absorbing dyes)[1]
Apexbio Technology LLC 10058-F4 403811-55-2 10mM (in 1mL DMSO)
10058-F4 (CAS 403811-55-2) is a small molecule inhibitor targeting the transcription factor c-Myc It disrupts the dimerization of c-Myc with Max thereby preventing the c-Myc/Max complex from binding to DNA This disruption impairs c-Myc-dependent transcriptional activity leading to inhibited proliferation and induction of apoptosis in leukemia cells as evidenced by Bcl-2 downregulation Bax upregulation and cytochrome c release 10058-F4 has also been shown to suppress growth factor-induced expression of PGC-1 implicating c-Myc in related transcriptional events Additionally in lymphoma cells it reduces c-Myc mRNA levels The compound is widely used in research to investigate c-Myc function in oncogenesis and cellular metabolism
Medchemexpress LLC Oxanilide (N,N'-diphenyloxalamide) | 620-81-5 | MFCD00041758 | 240.26 g/mol | C14H12N2O2 | 100 G
Oxanilide (N,N'-diphenyloxalamide) is a small-molecule chemical intermediate used in organic synthesis and medicinal chemistry research, notably for constructing quinoline and disulfide derivatives. It is supplied as a solid and is intended for laboratory research applications; consult product documentation for handling and purity details.
- Chemical intermediate for quinoline and disulfide derivative synthesis.
- Solid form suitable for storage and handling in research laboratories.
- Molecular weight 240.26 g/mol and chemical formula C14H12N2O2.
- Available in multiple pack sizes, including 100 g, for scalability of experiments.
- Intended for research use only and not for human use.
eMolecules AA Blocks LLC 2-Amino-3-bromophenol 100mg 524647784 AA000CF4 0 000 116435-77-9 MFCD08445676 188 024 C6H6BrNO
AA Blocks LLC 2-Amino-3-bromophenol 100mg 524647784 AA000CF4 0 000 116435-77-9 MFCD08445676 188 024 C6H6BrNO
Medchemexpress LLC TNF RII/TNFRSF1B Mo 1mg
Recombinant extracellular domain of mouse tumor necrosis factor receptor 2 (TNFRSF1B), expressed in HEK293 cells and supplied with a C-terminal His tag. The protein is purified and quality-controlled for use in biochemical binding studies, functional assays, and reagent development; typical reported purity is ~97.9%.
- Purified extracellular domain suitable for binding studies and assays.
- Expressed in HEK293 cells to preserve mammalian post-translational modifications.
- C-terminal His tag enables straightforward purification and detection.
- Available in multiple sizes to accommodate small-scale and larger experiments.
- High reported purity supports reliable biochemical and functional results.
- Provided with QC data such as purity and SDS-PAGE for lot verification.
Medchemexpress LLC Tk-129 | 3031476-73-7 | C15H23N5O2 | 1 ML
TK-129 is an orally active, low-toxicity, and potent KDM5B inhibitor with a high affinity (IC50=44 nM). It demonstrates cardioprotective effects by inhibiting KDM5B and interfering with the KDM5B-associated Wnt pathway. In vitro studies, TK-129 reduces ang II-induced activation of cardiac fibroblasts. In vivo, it has been shown to reduce isoprenaline-induced myocardial remodelling and fibrosis. This compound is suitable for use in studies related to cardiovascular disease.
- Orally active
- Low-toxicity
- Potent KDM5B inhibitor
- High affinity (IC50=44 nM)
- Cardioprotective effects
- Inhibits KDM5B and blocks the KDM5B-associated Wnt pathway
- Reduces ang ii-induced activation of cardiac fibroblasts in vitro
- Reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo
- Suitable for cardiovascular disease studies
Medchemexpress LLC Epoprostenol sodium | 61849-14-7 | 98.03% | C20H31NaO5 | 1 MG
Epoprostenol sodium (Prostaglandin I2) sodium salt is the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2). It is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH) and is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation.
- Registered worldwide for the treatment of pulmonary arterial hypertension (PAH).
- Used in pulmonary hypertension and transplantation.
- Potent inhibitor of platelet aggregation.
- Induces apoptosis in PAH-PASMCs by upregulating the expression of IP receptor and Fas ligand (FasL).
- Storage at -20°C, sealed, away from moisture.
- Compound is unstable in solutions; freshly prepared solutions are recommended.
Cambridge Isotope Laboratories 2 2 3 3 4 5 5 6 6-NonaBDE (BDE-208) (13C12 99%) 50 ug/mL in nonane 1 2 mL
2 2 3 3 4 5 5 6 6-NonaBDE (BDE-208) (13C12 99%) 50 ug/mL in nonane 1 2 mL
Medchemexpress LLC SE-7552 | 2243575-79-1 | 99.5% | 335.28 | 1 ML
SE-7552, a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM. It demonstrates greater than 850-fold selectivity versus all other known HDAC isozymes. This compound is capable of blocking multiple myeloma growth in vivo and acts as an anti-obesity agent in diet-induced obese mice.
- High selectivity for HDAC6
- Oral activity
- Non-hydroxamate nature
- Shown efficacy in blocking multiple myeloma growth in vivo
- Acts as an anti-obesity agent
Medchemexpress LLC Polyethylene glycol 20000 | 25322-68-3 | 20000.00 Da | H(OCH2CH2)nOH | 250g
PEG20000 (Polyethylene glycol 20000) can be used as a solubilizer PEG20000 is a kind of biological materials or organic compounds that are widely used in life science research can be degraded by bacteria[1][2]
Medchemexpress LLC Benzaldehyde, 2,4,5-trimethoxy- | 4460-86-0 | MFCD00003312 | 99.8% | 196.20 g/mol | C10H12O4 | 500 G
Asaraldehyde (2,4,5-trimethoxybenzaldehyde) is a naturally occurring aromatic aldehyde used as a research reagent and reported COX-2 inhibitor. It is supplied as a high-purity solid for analytical and biochemical studies and has documented activity against cyclooxygenase-2 at 100 μg/mL.
- Reported COX-2 inhibitor, IC50 = 100 μg/mL.
- Chemical formula C10H12O4.
- Molecular weight 196.20 g/mol.
- High purity (99.8%).
- Provided as a solid suitable for analytical and assay use.
- Available in large pack sizes for bulk laboratory applications.
- Intended for research use only; not for human consumption.
Medchemexpress LLC DFRF4539A RG-7598 1mg | 1mg
DFRF4539A (RG-7598) is a human-derived antibody expressed in CHO that targets FcRH5/IRTA2/CD307e DFRF4539A (RG-7598) carries a huIgG1 heavy chain and a hu light chain with a predicted molecular weight (MW) of 150 kDa The isotype control for DFRF4539A (RG-7598) can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC 2-Bromo-5-fluoropyridine | 41404-58-4 | 99.5% | 175.99 | 100 G
2-Bromo-5-fluoropyridine is an intermediate used in organic synthesis. It can undergo Suzuki coupling reactions with boronic acid and is utilized in the synthesis of GSK1292263A, a GPR119 receptor agonist. This compound appears as a solid below 30°C and a liquid above 31°C, with a colorless to off-white appearance. It is soluble in DMSO and various in vivo protocols, offering flexibility for different research applications.
- Intermediate for organic synthesis
- Undergoes Suzuki coupling reactions
- Used in synthesis of GPR119 receptor agonist
- Solid below 30°C, liquid above 31°C
- Colorless to off-white appearance
- Soluble in DMSO and various in vivo protocols