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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Also available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Fenclozine Maleate (S 1429) is a potential histamine H1 receptor antagonist , which can be used to study fever, inflammation and pain. Purity 98.47%
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ER-27319 (maleate), an acridone derivative, is a potent and selective SYK inhibitor. It inhibits the tyrosine phosphorylation of SYK and its activity, and can be used for study in allergic diseases. It also inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM.
Potent and selective SYK inhibitor
Inhibits tyrosine phosphorylation of SYK
Inhibits release of antigen-induced allergic mediators
Suitable for study in allergic diseases
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Zamifenacin fumarate is the fumarate salt of zamifenacin (UK-76654), a gut-selective muscarinic M3 receptor antagonist used in research to study gastrointestinal motility. It is provided as a high-purity solid for use in in vitro and in vivo pharmacology studies targeting colonic motility.
Potent gut-selective muscarinic M3 receptor antagonist that reduces colonic motility.
High purity suitable for research applications (99.0%).
Solid, white to off-white form for convenient handling and dosing.
Molecular weight 531.60 g/mol, molecular formula C31H33NO7.
Recommended storage at 4°C; in solution, -80°C for long-term stability.
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U-99194 maleate is a selective, potent dopamine D3 receptor antagonist with a Kᵢ of 160 nM. It inhibits the activation of the D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. This compound can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
Selective, potent dopamine D3 receptor antagonist
Inhibits activation of D3 receptor
Abrogates the IPSC-suppressive effect of D3 agonists
Significantly suppresses Nicotine-induced tremor in mice
Useful for studying dopamine D3 receptor-mediated motor disorders
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Potent, selective and non-competitive NMDA receptor antagonist (Ki = 30.5 nM); acts at the NMDA receptor-operated ion channel as an open channel blocker, preventing Ca2+ flux
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(S)-Timolol maleate is a non-cardioselective hydrophilic β-adrenoceptor blocker, widely used as a standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. It also finds application in hypertension, angina pectoris, and myocardial infarction. This product is suitable for research and analytical applications.