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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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ER-27319 (maleate), an acridone derivative, is a potent and selective SYK inhibitor. It inhibits the tyrosine phosphorylation of SYK and its activity, and can be used for study in allergic diseases. It also inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM.
Potent and selective SYK inhibitor
Inhibits tyrosine phosphorylation of SYK
Inhibits release of antigen-induced allergic mediators
Suitable for study in allergic diseases
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Zamifenacin fumarate is the fumarate salt of zamifenacin (UK-76654), a gut-selective muscarinic M3 receptor antagonist used in research to study gastrointestinal motility. It is provided as a high-purity solid for use in in vitro and in vivo pharmacology studies targeting colonic motility.
Potent gut-selective muscarinic M3 receptor antagonist that reduces colonic motility.
High purity suitable for research applications (99.0%).
Solid, white to off-white form for convenient handling and dosing.
Molecular weight 531.60 g/mol, molecular formula C31H33NO7.
Recommended storage at 4°C; in solution, -80°C for long-term stability.
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Tegaserod maleate is an orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist and a 5-HT2B receptor antagonist. This compound induces tumor cell apoptosis, attenuates PI3K/Akt/mTOR signaling, and reduces S6 phosphorylation. It demonstrates anti-tumor activity and is being investigated for its potential in irritable bowel syndrome (IBS) research.
Orally active serotonin receptor 4 (HTR4; 5-HT4R) agonist
5-HT2B receptor antagonist
Induces tumor cell apoptosis
Attenuates PI3K/Akt/mTOR signaling
Reduces S6 phosphorylation
Demonstrates anti-tumor activity
Potential for irritable bowel syndrome (IBS) research
For research use only
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Edonerpic maleate is a novel neurotrophic agent that inhibits amyloid-β peptides (Aβ). It has been shown to preserve cortical neurons in the presence of Aβ(1-42) and prevent oxidative stress-induced neuronal death.
Prevents oxidative stress-induced neuronal death.
Almost completely prevents GSH reduction.
Significantly increases neurite length in hippocampal slices.
Ameliorates deficits in adult neurogenesis and spatial memory in rats.
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Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
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(S)-Timolol maleate is a non-cardioselective hydrophilic β-adrenoceptor blocker, widely used as a standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. It also finds application in hypertension, angina pectoris, and myocardial infarction. This product is suitable for research and analytical applications.
Rosiglitazone maleate (CAS 155141-29-0) is the maleate salt formulation of rosiglitazone a thiazolidinedione compound targeting the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR ) By selective activation of PPAR rosiglitazone increases insulin sensitivity of peripheral tissues facilitating glucose uptake and reduction of blood glucose levels Due to its insulin-sensitizing activity rosiglitazone maleate serves as an important research tool in diabetes and metabolic syndrome investigations However recent clinical studies also report associations with adverse cardiovascular events fluid retention and anemia underscoring considerations for risk-benefit evaluation in ongoing research
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Chemical. CAS 596-09-8. Formula C24H16O7. MW 416.38. Synthetic. FDA is a non-fluorescent hydrophobic fluorescein derivative that can pass through the cell membrane whereupon intracellular esterases hydrolyze the diacetate group producing the highly fluorescent product fluorescein. The fluorescein molecules accumulate in cells that possess intact membranes so the green fluorescence can be used as a marker of cell viability. Cells that do not possess an intact cell membrane or an active metabolism may not accumulate the fluorescent product and therefore do not exhibit green fluorescence. FDA may be used in combination with PI staining as the non-viable cells take up the PI and stain dead cells red whereas viable cells do not take up the PI and should only stain green. This 2-color separation of non-viable and viable cells may provide a more accurate quantitation of cell viability than single color analysis.
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