Azoles
Medchemexpress LLC CA-5f | 1370032-19-1 | 99.1% | 388.46 | 1 MG
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor that works by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker for monitoring autophagy) and SQSTM1 protein levels, and also leads to increased ROS production. The compound has demonstrated anti-tumor activity.
- Potent late-stage macroautophagy/autophagy inhibitor.
- Inhibits autophagosome-lysosome fusion.
- Increases LC3B-II and SQSTM1 protein levels.
- Increases ROS production.
- Exhibits anti-tumor activity.
- Inhibits growth of A549 cells and is less cytotoxic to normal HUVECs in vitro.
- Well tolerated and potently inhibits tumor growth in nude mice bearing A549 lung cancer cells in vivo.
- Suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
Cayman Chemical Phytanic Acid methyl ester, Purity: ≥95%, CAS: 1118-77-0, 50 mg
A long-chain fatty acid methyl ester
Medchemexpress LLC CA-5f | 1370032-19-1 | 99.1% | 388.46 | 1 ML
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor, working by inhibiting autophagosome-lysosome fusion. It increases LC3B-II and SQSTM1 protein levels and also increases ROS production, demonstrating anti-tumor activity.
- Potent late-stage macroautophagy/autophagy inhibitor
- Inhibits autophagosome-lysosome fusion
- Increases LC3B-II protein and SQSTM1 protein
- Increases ROS production
- Exhibits anti-tumor activity
- Inhibits the growth of A549 cells, and is less cytotoxic to normal HUVECs in vitro
- Does not impair the hydrolytic function or quantity of lysosomes in vitro
- Well tolerated and potently inhibits tumor growth in nude mice bearing A549 lung cancer cells in vivo
- Suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells in vivo
Medchemexpress LLC HY-18620 5mg Medchemexpress, DZ2002 CAS:33231-14-0 Purity:>98%
Medchemexpress, HY-18620 5mg DZ2002 CAS:33231-14-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Delamanid-5mg
Delamanid (OPC-67683) is a new anti-tuberculosis drug with an excellent intracellular bactericidal activity and a high accumulation rate.
Chemscene ChemScene | N6-Methyladenosine | 5G | CS-3285 | 0.98 | 1867-73-8| MFCD00005739 | 281.27
ChemScene | N6-Methyladenosine | 5G | CS-3285 | 0.98 | 1867-73-8| MFCD00005739 | 281.27
![Accela Chembio Inc 3-bromoimidazo[1 | 2-b]pyridazine | 5g | 18087-73-5 | MFCD09757672 | 97+% | Shelf Life: 1260 Days | Light Sensitive](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00116475-SY007258-5G.PNG-250.jpg)
Accela Chembio Inc 3-bromoimidazo[1 | 2-b]pyridazine | 5g | 18087-73-5 | MFCD09757672 | 97+% | Shelf Life: 1260 Days | Light Sensitive
3-bromoimidazo[1 | 2-b]pyridazine | 5g | 18087-73-5 | MFCD09757672 | 97+% | Shelf Life: 1260 Days | Light Sensitive
Accela Chembio Inc 1-hexyl-3-methylimidazolium Tetrafluoroborate | 5g | 244193-50-8 | MFCD03095459 | 97+% | D: 1.149 | Shelf Life: 1440 Days | Moisture Sensitive/n2
1-hexyl-3-methylimidazolium Tetrafluoroborate | 5g | 244193-50-8 | MFCD03095459 | 97+% | D: 1.149 | Shelf Life: 1440 Days | Moisture Sensitive/n2
Selleck Chemical LLC Orteronel S1195-5mg
Orteronel(TAK-700) is a potent and highly selective human 17 20-lyase inhibitor with IC50 of 38 nM exhibits 1000-fold selectivity over other CYPs (e g 11-hydroxylase and CYP3A4) TAK-700 (Orteronel) is an androgen biosynthesis inhibitor Phase 3
Selleck Chemical LLC RAF265 (CHIR-265) S2161-5mg
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays RAF265 (CHIR-265) induces cell cycle arrest and apoptosis Phase 2
![Accela Chembio Inc 6-chloroimidazo[1 | 2-b]pyridazine | 5g | 6775-78-6 | MFCD07778345 | 98% | Shelf Life: 1080 Days | Light Sensitive/n2/+4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00116475-SY004897-5G.PNG-250.jpg)
Accela Chembio Inc 6-chloroimidazo[1 | 2-b]pyridazine | 5g | 6775-78-6 | MFCD07778345 | 98% | Shelf Life: 1080 Days | Light Sensitive/n2/+4
6-chloroimidazo[1 | 2-b]pyridazine | 5g | 6775-78-6 | MFCD07778345 | 98% | Shelf Life: 1080 Days | Light Sensitive/n2/+4
Medchemexpress LLC Tenofovir-d6 (racemic) | 1020719-94-1 | MFCD07369651 | 99.8% | 293.25 g/mol | C9H8D6N5O4P | 5 MG
(Rac)-Tenofovir-d6 is a deuterium-labeled, racemic form of tenofovir used as a stable isotope reference and analytical standard. It is intended for pharmacokinetic, metabolism, and quantitative bioanalysis studies of tenofovir and related nucleotide reverse transcriptase inhibitors.
- Deuterium-labeled (d6) racemic tenofovir.
- High purity and isotopic enrichment for accurate quantitation.
- Suitable as an internal standard for LC-MS/MS assays.
- Ideal for pharmacokinetic and metabolic tracing studies.
- Supplied in milligram-scale quantities for analytical use.
- Store at -20 °C and protect from light.
Medchemexpress LLC HY-18299 5mg Medchemexpress, Purvalanol B CAS:212844-54-7 Purity:>98%
Medchemexpress, HY-18299 5mg Purvalanol B CAS:212844-54-7 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC CycloRGDyK-5mg
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.