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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
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ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor. It inhibits human NAAA with an IC50 of 230 nM and has demonstrated analgesic (pain-relief) effects in animal models. Supplied as a white to off-white solid for preclinical research.
Selective, orally active reversible NAAA inhibitor.
Human NAAA IC50: 230 nM.
Brain-penetrant compound suitable for in vivo studies.
High purity (99.8%) and white to off-white appearance.
Molecular formula C21H22FN3O3S2; molecular weight 447.55.
Recommended storage: powder at -20°C for long term or 4°C for short term.
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Tris(2,4-di-tert-butylphenyl)phosphate is an active compound derived from the leaves of Vitex negundo L. It demonstrates anti-inflammatory activity by inhibiting secretory Phospholipase A2 (sPLA2) through molecular docking. In vivo studies show that at doses of 50 mg/kg and 70 mg/kg, it significantly reduces paw edema volume in a carrageenan-induced paw edema model.
Active compound from Vitex negundo L.
Demonstrates anti-inflammatory activity
Inhibits secretory Phospholipase A2 (sPLA2)
Effective in reducing paw edema volume in vivo
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Aganepag is a potent Prostanoid EP2 receptor agonist with an EC50 of 0.19 nM, showing no activity at the EP4 receptor. It is used in the research of wound healing, scar reduction, scar prevention, and wrinkle treatment and prevention.
Potent Prostanoid EP2 receptor agonist with an EC50 of 0.19 nM.
No activity at EP4 receptor.
Can be used in wound healing research.
Applicable for scar reduction and prevention studies.
Useful for wrinkle treatment and prevention research.
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This small-molecule Hsp90 inhibitor is supplied for biochemical and cellular research applications. It exhibits potent binding to human and Plasmodium Hsp90 and is provided as a high-purity reagent for in vitro studies.
High purity of 99.1% supports reproducible results.
Soluble in DMSO for straightforward preparation of stock solutions.
Molecular formula C22H26FN3O3 and molecular weight 399.46 g/mol aid in calculations and dosing.
Available in small research-friendly quantities for screening and assay development.
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ML604086 is a small-molecule CCR8 antagonist used in research to block CCL1-CCR8 interactions. It inhibits CCL1 binding to CCR8 on circulating T cells, reduces CCL1-mediated chemotaxis, and has been characterized in cell-based assays and preclinical in vivo studies, including non-human primate models.
Selective CCR8 antagonist that inhibits CCL1 binding to CCR8.
Inhibits CCL1-mediated chemotaxis and modulates intracellular Ca2+ responses.
Characterized in vitro and in vivo, including primate pharmacology studies.
Supplied as a solid for laboratory research use.
Molecular weight 508.63 g·mol-1; formula C27H32N4O4S; CAS 850330-18-6.
Typical research-grade purity >98% with low-temperature storage recommended.
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