Aminobenzoic acids and derivatives
AdipoGen Salinosporamide A
Chemical. CAS 437742-34-2. Formula C15H20ClNO4. MW 313.8. Isolated from Salinospora tropica. Potent, irreversible inhibitor of all the 3 proteolytic activities of the mammalian 20S proteasome. beta5 subunit chymotrypsin-like EC50 = 3.5nM beta2 subunit trypsin-like EC50 = 28nM beta1 subunit caspase-like or peptidyl-glutamyl peptide-hydrolyzing PGPH EC50 = 430nM Potent anticancer compound. Triggers apoptosis, with distinct proteasome activity and mechanism of action compared to bortezomib Velcade Prod. No. AG-CR1-3602. Most potent suppressor of NF-kappaB activation, compared with bortezomib, MG-132 Prod. No. AG-CP3-0011, N-acetyl-leucyl-leucyl-norleucinal ALLN and lactacystin Prod. No. AG-CN2-0104. Inhibitor of TNF-alpha, IL-1, IL-6, ICAM-1 and VEGF synthesis. Displays a longer inhibition duration than bortezomib. Potent antileukemic activity against bortezomib-resistant leukemia cells.
AdipoGen Salinosporamide A
Chemical. CAS 437742-34-2. Formula C15H20ClNO4. MW 313.8. Isolated from Salinospora tropica. Potent, irreversible inhibitor of all the 3 proteolytic activities of the mammalian 20S proteasome. beta5 subunit chymotrypsin-like EC50 = 3.5nM beta2 subunit trypsin-like EC50 = 28nM beta1 subunit caspase-like or peptidyl-glutamyl peptide-hydrolyzing PGPH EC50 = 430nM Potent anticancer compound. Triggers apoptosis, with distinct proteasome activity and mechanism of action compared to bortezomib Velcade Prod. No. AG-CR1-3602. Most potent suppressor of NF-kappaB activation, compared with bortezomib, MG-132 Prod. No. AG-CP3-0011, N-acetyl-leucyl-leucyl-norleucinal ALLN and lactacystin Prod. No. AG-CN2-0104. Inhibitor of TNF-alpha, IL-1, IL-6, ICAM-1 and VEGF synthesis. Displays a longer inhibition duration than bortezomib. Potent antileukemic activity against bortezomib-resistant leukemia cells.
Medchemexpress LLC Octadecanoic acid, 10-hydroxy- | 638-26-6 | MFCD08693364 | 99.8% | 300.48 g/mol | C18H36O3 | 25 MG
10-Hydroxystearic acid (10-HSA) is a hydroxylated stearic acid provided as a research reagent. It functions as a PPARα agonist and has been reported to stimulate collagen synthesis and exhibit anti-aging effects such as reducing the appearance of pores and hyperpigmentation. Supplied at high purity for in vitro and formulation studies.
Medchemexpress LLC Pyropheophorbide-a | 24533-72-0 | 98.0% | 1 ML
Pyropheophorbide-a (Ppa) is a potent photosensitizer primarily used in photodynamic therapy (PDT) for the treatment of various tumors. This compound demonstrates significant phototoxic effects on tumor cells, such as cervical cancer cells, and also exhibits anti-lipogenesis activity. Its potential applications extend to research in cancer and age-related macular degeneration (AMD), with derivatives also showing inhibitory activity against tumor cells.
- Photosensitizer for photodynamic therapy
- Exhibits phototoxic effects on tumor cells
- Demonstrates anti-lipogenesis activity
- Potential for research in cancer and age-related macular degeneration (AMD)
- Derivatives show inhibitory activity against tumor cells
Medchemexpress LLC Kushenol A | 99217-63-7 | 1 ML
Kushenol A (Leachianone E) is a flavonoid antioxidant isolated from the root of Sophora flavescent. This compound acts as a non-competitive tyrosinase inhibitor, blocking the conversion of L-tyrosine to L-DOPA. It also shows inhibitory effects on alpha-glucosidase and β-amylase, making it a potential candidate for cosmetic applications in skin whitening and anti-aging.
- Isolated from the root of Sophora flavescent
- Non-competitive tyrosinase inhibitor
- Blocks conversion of L-tyrosine to L-DOPA
- Flavonoid antioxidant
- Inhibits alpha-glucosidase and β-amylase
- Potential for skin whitening and anti-aging applications
- Highly potent inhibitory activity on ABTS•+ radical scavenging
- Exhibits cytotoxic effects against NSCLC cells
AdipoGen Cyclosporin A
Chemical. CAS 59865-13-3. Formula C62H111N11O12. MW 1202.6. Isolated from Tolypocladium inflatum. Potent immunosuppressant same as FK-506 Prod. No. AG-CN2-0047 and rapamycin Prod. No. AG-CN2-0025. Forms a complex with cyclophilin. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B PP2B calcineurin. Prevents the dephosphorylation of nuclear factor of activated T cells NFAT transcription factor, leading to disruption of T cell activation. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 IL-2. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases e.g. atopic dermatitis and with potential anti-rheumatic activity rheumatoid arthritis. Antibacterial. Antifungal. Antiparasitic. Apoptosis inhibitor.
TARGETMOL CHEMICALS INC PD146176 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 uM. PD146176 reverses cognitive impairment brain amyloidosis and tau pathology by stimulating autophagy in aged triple transgenic mice. purity: 99%
Medchemexpress LLC Guanidinosuccinic acid | 6133-30-8 | 98.0% | 175.14 | 1 ML
Guanidinosuccinic acid is a nitrogenous metabolite that is elevated in the urine and serum of azotemic patients. It is a guanidino compound that has been shown to induce long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner in adult mice when administered intraperitoneally. In young mice, an age-dependent decrease in Guanidinosuccinic acid-induced convulsions and brain concentration was observed. The product is for research use only and not intended for sale to patients.
- Endogenous metabolite
- Elevated in azotemic patients
- Exhibits epileptogenic and toxic properties in mice
Apexbio Technology LLC Ibutamoren Mesylate 159752-10-0 5mg
Ibutamoren mesylate (CAS 159752-10-0) also known as MK-0677 is an orally bioavailable nonpeptide growth hormone (GH) secretagogue It acts by stimulating GH release via activation of ghrelin receptors located in the pituitary and hypothalamus distinct from the classical GH-releasing hormone receptor Administration of ibutamoren mesylate results in elevated plasma concentrations of growth hormone and insulin-like growth factor 1 (IGF-1) without significantly affecting cortisol levels This compound is under investigation for its ability to enhance muscle mass and bone mineral density and is being studied as a potential therapy for conditions involving GH deficiency or age-related frailty
Apexbio Technology LLC Ibutamoren Mesylate 159752-10-0 10mg
Ibutamoren mesylate (CAS 159752-10-0) also known as MK-0677 is an orally bioavailable nonpeptide growth hormone (GH) secretagogue It acts by stimulating GH release via activation of ghrelin receptors located in the pituitary and hypothalamus distinct from the classical GH-releasing hormone receptor Administration of ibutamoren mesylate results in elevated plasma concentrations of growth hormone and insulin-like growth factor 1 (IGF-1) without significantly affecting cortisol levels This compound is under investigation for its ability to enhance muscle mass and bone mineral density and is being studied as a potential therapy for conditions involving GH deficiency or age-related frailty
Apexbio Technology LLC Ibutamoren Mesylate 159752-10-0 50mg
Ibutamoren mesylate (CAS 159752-10-0) also known as MK-0677 is an orally bioavailable nonpeptide growth hormone (GH) secretagogue It acts by stimulating GH release via activation of ghrelin receptors located in the pituitary and hypothalamus distinct from the classical GH-releasing hormone receptor Administration of ibutamoren mesylate results in elevated plasma concentrations of growth hormone and insulin-like growth factor 1 (IGF-1) without significantly affecting cortisol levels This compound is under investigation for its ability to enhance muscle mass and bone mineral density and is being studied as a potential therapy for conditions involving GH deficiency or age-related frailty
Apexbio Technology LLC Ibutamoren Mesylate 159752-10-0 100mg
Ibutamoren mesylate (CAS 159752-10-0) also known as MK-0677 is an orally bioavailable nonpeptide growth hormone (GH) secretagogue It acts by stimulating GH release via activation of ghrelin receptors located in the pituitary and hypothalamus distinct from the classical GH-releasing hormone receptor Administration of ibutamoren mesylate results in elevated plasma concentrations of growth hormone and insulin-like growth factor 1 (IGF-1) without significantly affecting cortisol levels This compound is under investigation for its ability to enhance muscle mass and bone mineral density and is being studied as a potential therapy for conditions involving GH deficiency or age-related frailty
ILEX LIFE SCIENCES LLC ACTIVE GHRELIN ELISA 2 X 96W
Yanaihara Institute Active Ghrelin Human/Rat/Mouse ELISA Kit (2 x 96 wells). DESCRIPTION: Active Ghrelin Human/Rat/Mouse ELISA kit, developed and manufactured in Japan by Yanaihara Institute Inc., is used for quantitative measurement of the active form of Ghrelin in plasma samples. This multispecies assay can detect not only octanoylated human Ghrelin but also octanoylated rat/mouse Ghrelin (1-28). The kit uses the highly specific antibody pairs generated by Dr. Kangawa and by following his protocol. QUANTITY: With one 96-well plate, 40 samples can be measured in duplicate. The plate consists of 8-well strips that can be used separately. NOTE: This assay uses the same antibody as the discontinued LSI Medicine Active Ghrelin ELISA (cat. no. 97751). ASSAY RANGE: 2.9 - 184 fmol/mL. OTHER NAMES: Acylated ghrelin (AG), Acyl-ghrelin, octanoyl ghrelin, Appetite-regulating hormone, GH secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46, GHRL, MTLRP.
ILEX LIFE SCIENCES LLC ACTIVE GHRELIN ELISA 3 X 96W
Yanaihara Institute Active Ghrelin Human/Rat/Mouse ELISA Kit (3 x 96 wells). DESCRIPTION: Active Ghrelin Human/Rat/Mouse ELISA kit, developed and manufactured in Japan by Yanaihara Institute Inc., is used for quantitative measurement of the active form of Ghrelin in plasma samples. This multispecies assay can detect not only octanoylated human Ghrelin but also octanoylated rat/mouse Ghrelin (1-28). The kit uses the highly specific antibody pairs generated by Dr. Kangawa and by following his protocol. QUANTITY: With one 96-well plate, 40 samples can be measured in duplicate. The plate consists of 8-well strips that can be used separately. NOTE: This assay uses the same antibody as the discontinued LSI Medicine Active Ghrelin ELISA (cat. no. 97751). ASSAY RANGE: 2.9 - 184 fmol/mL. OTHER NAMES: Acylated ghrelin (AG), Acyl-ghrelin, octanoyl ghrelin, Appetite-regulating hormone, GH secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46, GHRL, MTLRP.
ILEX LIFE SCIENCES LLC ACTIVE GHRELIN ELISA 96 WELLS
Yanaihara Institute Active Ghrelin Human/Rat/Mouse ELISA Kit (96 wells). DESCRIPTION: Active Ghrelin Human/Rat/Mouse ELISA kit, developed and manufactured in Japan by Yanaihara Institute Inc., is used for quantitative measurement of the active form of Ghrelin in plasma samples. This multispecies assay can detect not only octanoylated human Ghrelin but also octanoylated rat/mouse Ghrelin (1-28). The kit uses the highly specific antibody pairs generated by Dr. Kangawa and by following his protocol. QUANTITY: With one 96-well plate, 40 samples can be measured in duplicate. The plate consists of 8-well strips that can be used separately. NOTE: This assay uses the same antibody as the discontinued LSI Medicine Active Ghrelin ELISA (cat. no. 97751). ASSAY RANGE: 2.9 - 184 fmol/mL. OTHER NAMES: Acylated ghrelin (AG), Acyl-ghrelin, octanoyl ghrelin, Appetite-regulating hormone, GH secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46, GHRL, MTLRP.