Benzenesulfonamides
Apexbio Technology LLC Sildenafil mesylate 1308285-21-3 25mg
Sildenafil mesylate (CAS 1308285-21-3) is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) exhibiting an IC50 of 3 5 nM By inhibiting PDE5-mediated cGMP hydrolysis it enhances endogenous cGMP levels particularly within corpus cavernosum tissue In vitro sildenafil mesylate reversibly potentiates relaxation responses in precontracted corpus cavernosum strips following sodium nitroprusside exposure or electrical stimulation and increases intracellular cGMP in treated smooth muscle cells In vivo it augments erectile responses in anesthetized canine models This compound is widely used for studying PDE5-related signaling pathways and pharmacological modulation in erectile and vascular function research
eMolecules 3-HYDROXYBENZENESULFONAMIDE | 20759-40-4 | MFCD16999679 | 1g
AstaTech | 3-HYDROXYBENZENESULFONAMIDE | 1g | 449751921 | AB10153 | 95.000 | 20759-40-4 | MFCD16999679 | 173.190 | C6H7NO3S
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![eMolecules 3-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | 880769-95-9 | MFCD09839041 | 25g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502190348.JPG-250.jpg)
eMolecules 3-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | 880769-95-9 | MFCD09839041 | 25g
Combi-Blocks | 3-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | 25g | 482931900 | QA-2461 | 95.000 | 880769-95-9 | MFCD09839041 | 337.190 | C13H9BrN2O2S
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Medchemexpress LLC HY-15833 50mg , Chlorthalidone CAS:77-36-1 Purity:98%
Medchemexpress, HY-15833 50mg Chlorthalidone CAS:77-36-1 Formula:C14H11ClN2O4S Purity:98% Chlorthalidone is a thiazide-like diuretic used to treat hypertension. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-10410 5mg Medchemexpress, TG101209 CAS:936091-14-4 Purity:>98%
Medchemexpress, HY-10410 5mg TG101209 CAS:936091-14-4 TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-111108 5mg Medchemexpress, LDH-IN-1 CAS:1964515-43-2 Purity:>98%
Medchemexpress, HY-111108 5mg LDH-IN-1 CAS:1964515-43-2 LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Organic Chemistry 1,1-Bis(phenylsulfonyl)ethylene | 1G | 39082-53-6 | MFCD00043149
CAS #: 39082-53-6
MDL #: MFCD00043149
Purity: 98% (CH)
UNSPSC Code: 12352100
Molecular Weight: 308.37
Apexbio Technology LLC OSMI-1,5mg CAS# 1681056-61-0
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM, it is cell permeable[1]. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours[1]. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031 mg/mL (56 μM, 12 h) and 0.025 mg/mL (45 μM, 24 h) in zebrafish model[2]. References:[1]. Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol, 2015, 10(6): 1392-7.Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep, 2017, 7(1): 12334. Other sizes are also available. Please inqury us for quote.