Benzenesulfonamides
Medchemexpress LLC Desmorpholinyl navitoclax-NH-Me | 2365172-82-1 | 98.6% | C44H51ClF3N5O5S3 | 10MG
Desmorpholinyl Navitoclax-NH-Me is a research-grade derivative of navitoclax that functions as a Bcl-xL inhibitor. It is provided as a high-purity small-molecule reagent for biochemical and cellular studies, with available analytical characterization and safety documentation.
- High purity suitable for research applications.
- Characterized by certificate of analysis, LCMS, and H NMR data.
- Available in multiple small pack sizes for laboratory use.
- Supplied with safety data sheet and handling instructions.
- Applicable for Bcl-xL inhibition studies in biochemical and cellular assays.
Electron Microscopy Sciences SEM Scintillator YAP 12.4x3.2 mm
YAP (Yttrium Aluminum Perovskite activated by Ce3+) shares the same advantages as YAG but is more efficient in terms of light output than YAG crystals. As well, the emission spectrum peaks at about 378nm, and this corresponds closely to the maximum sensitivity of the S11 photocathode which in general is used in most scanning electron microscopes. (There would be more improvement in signal by using a YAP crystal rather than YAG in these microscopes). The decay time of YAP (40ns) is faster than YAG (80ns) so its overall performance is superior to YAG.
YAP crystals should be coated with 50nm of aluminum prior to use. Note: P-47 is usually in-stock. YAG and YAP delivery time is 6-8 weeks. Use with Cameca scanning electron microscopes.
Chemscene ChemScene | 2,4-Difluorobenzenesulfonamide | 25G | CS-W010691 | 0.98 | 13656-60-5| MFCD01320743 | 193.17
ChemScene | 2,4-Difluorobenzenesulfonamide | 25G | CS-W010691 | 0.98 | 13656-60-5| MFCD01320743 | 193.17
Medchemexpress LLC Sulfasalazine | 599-79-1 | >99.6% | 398.39 | 10 G
Sulfasalazine is an anti-rheumatic agent investigated for conditions like rheumatoid arthritis and ulcerative colitis. Its mechanism involves suppressing NF-κB activity and acting as a type 1 ferroptosis inducer.
- Anti-rheumatic properties.
- Suppresses NF-κB activity.
- Induces type 1 ferroptosis.
- Under investigation for primary brain tumors and other conditions.
Medchemexpress LLC YAP/TAZ inhibitor-2 | 2762617-31-0 | 99.8% | 390.33 | 5 MG
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM. It demonstrates significant anti-proliferative and anti-tumor activities in both in vitro and in vivo studies.
- Potent and orally active TEAD-YAP/TAZ inhibitor
- Displays anti-proliferative activity with an IC50 of 5.33 nM in NCI-H226 cells
- Demonstrates anti-tumor activity in BALB/c nude mice xenograft models
- EC50 value of 3 nM
Medchemexpress LLC Sildenafil-d3 | 1126745-90-1 | C22H27D3N6O4S | 5 MG
Sildenafil-d3 is a deuterium-labeled version of Sildenafil, a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. This compound is suitable for various analytical applications.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Appearance: solid.
- Color: white to off-white.
- Purity: 99.87%.
- Target: PDE5.
- Molecular weight: 477.59.
Medchemexpress LLC Sildenafil | 139755-83-2 | C22H30N6O4S | 1 G
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.
- Potent PDE5 inhibitor
- IC50 of 5.22 nM against PDE5
- Potentiates ERK1/ERK2 phosphorylation
- Increases cell proliferation
- Increases intracavernosal pressure and ICP/blood pressure ratio in dog models
- Decreases the number of TL+-cells
- Reduces microglia/macrophages in pMCAo models
- Decreases flap necrosis in preclinical animal models
Medchemexpress LLC Glimepiride | 1131981-29-7 | 99.4% | C24H30D4N4O5S | 1 MG
Glimepiride-d4-1 is a deuterium-labeled version of Glimepiride, a medium-to-long acting sulfonylurea anti-diabetic compound. This labeled compound can be used for quantitative analysis and tracing in various scientific applications.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration may influence pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC 7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene | 84030-20-6 | 99.19% | C8H15N3 | 10 G
7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene is a drug intermediate, primarily used for the synthesis of various active compounds. It is supplied as a colorless to light yellow liquid. This product is intended for research use only.
- Drug intermediate for synthesis of various active compounds
- Colorless to light yellow liquid appearance
- Molecular weight of 153.23
- Chemical formula C8H15N3
Medchemexpress LLC AZD2098 | 566203-88-1 | 334.18 | 100 MG
AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0, and 7.6 for human, rat, mouse, and dog, respectively. It is used for asthma research.
- Potent and selective CCR4 inhibitor
- Used for asthma research
- Exhibits efficacy against antigen-induced inflammatory response
- Purity of 99.91%
Medchemexpress LLC N-Benzyl-N-Cbz-glycine | 76315-01-0 | MFCD02094473 | 265.31 | 5 G
2-(Benzyl(tert-butoxycarbonyl)amino)acetic acid, also known as N-Benzyl-N-Cbz-glycine, is a derivative of Glycine. It is intended for research use only and is not sold to patients. Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
- Amino acid derivative
- Purity: 98.0%
- Physical appearance: solid, ranging from white to off-white
- Molecular weight: 265.31
- Formula: C14H19NO4
- Cas no.: 76315-01-0
- Storage conditions:
- Powder: -20°c for 3 years, 4°c for 2 years
- In solvent: -80°c for 6 months, -20°c for 1 month
Enzo Life Sciences NBQX . disodium salt (25mg). CAS: 118876-58-7 (non-salt)
Water soluble, potent and selective AMPA/kainate receptor antagonist. For literature references, see NBQX (ALX-550-044). Alternative name: 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo(f)-quinoxaline . 2Na, 6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2,3-dione . 2Na. Purity: ≥98% (HPLC). Solubility: Soluble in water (5mg/ml) or DMSO. Long Term Storage: -20°C.
Medchemexpress LLC XMU-MP-3 | 2031152-08-4 | 95.8% | 536.55 | 50 MG
XMU-MP-3 is a potent non-covalent BTK inhibitor with IC50s of 10.7 nM for BTK WT and 17.0 nM for BTK C481S mutation in the presence of 10 μM ATP. It also induces apoptosis and inhibits the auto- and trans-phosphorylation of BTK at Y223 and Y551.
- Potent non-covalent BTK inhibitor
- Induces apoptosis
- Inhibits BTK-transformed Ba/F3 cell proliferation
- Maintains inhibitory potency against BTK(C481S)-Ba/F3 cells
- Substantially suppresses tumor growth in mouse xenograft models
Medchemexpress LLC HY-10799 5mg Medchemexpress, EG00229 CAS:1210945-69-9 Purity:>98%
Medchemexpress, HY-10799 5mg EG00229 CAS:1210945-69-9 EG00229 is a neuropilin 1 (NRP1) receptor antagonist. EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.