Benzenesulfonamides
Medchemexpress LLC Glimepiride-d5 | 1028809-90-6 | C24H29D5N4O5S | 1 MG
Glimepiride-d5 is the deuterium labeled Glimepiride, a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg. It is intended for research use only. This compound can be utilized as a tracer and as an internal standard for quantitative analysis. Deuterium labeling has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotopes incorporated into drug molecules
- Potential to affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC HY-U00443 5mg Medchemexpress, SB 258719 CAS:195199-95-2 Purity:>98%
Medchemexpress, HY-U00443 5mg SB 258719 CAS:195199-95-2 SB 258719 is a selective 5-HT 7 receptor antagonist with a pK i of 7.5. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Bosentan (hydrate) | 157212-55-0 | 99.9% | C27H31N5O7S | 200 MG
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors, with Ki values of 4.7 nM and 95 nM in human SMC, respectively. This product is for research use only.
- Competitive and dual antagonist of endothelin-1 (ET)
- Targets ETA and ETB receptors
- Ki values of 4.7 nM for ETA receptor and 95 nM for ETB receptor in human smooth muscle cells
- Appears as an off-white to light yellow solid
Apexbio Technology LLC N-Desmethyl Sildenafil 139755-82-1 25mg
N-Desmethyl Sildenafil (CAS 139755-82-1) is a pharmacologically active metabolite of sildenafil It acts as a selective inhibitor of phosphodiesterase type 5 (PDE5) modulating intracellular signaling pathways by preventing the degradation of cyclic guanosine monophosphate (cGMP) Experimental studies have demonstrated its inhibitory activity toward PDE5 implicating a role in the modulation of vascular and smooth muscle functions N-Desmethyl Sildenafil is utilized in biomedical research to study PDE5-related cellular processes and to explore potential therapeutic strategies targeting this enzyme
Medchemexpress LLC Yap/taz inhibitor-2 | 2762617-31-0 | 99.8% | C19H14F4N4O | 10MG
YAP/TAZ inhibitor-2 is a small-molecule TEAD-YAP/TAZ inhibitor with potent nanomolar activity that disrupts TEAD-YAP/TAZ signaling, shows antiproliferative effects in cancer cell lines, and demonstrates oral activity in vivo. The compound is supplied as a light yellow solid with documented solubility, storage, and purity information.
- Potent TEAD-YAP/TAZ inhibition (EC50 = 3 nM).
- Antiproliferative activity in NCI-H226 cells (IC50 = 5.33 nM).
- High chemical purity (99.81%).
- Soluble in DMSO (100 mg/mL).
- Stable as powder at -20°C for long-term storage.
- Light yellow to yellow solid appearance.
Medchemexpress LLC L-Aspartic acid, N-[2-[5-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihy | 871266-63-6 | 99.1% | 596.57 | 50 MG
L-Aspartic acid, N-[2-[5-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihy | 871266-63-6 | 99.1% | 596.57 | 50 MG
eMolecules 20759-40-4 | 3-HYDROXYBENZENESULFONAMIDE | MFCD16999679 | 1g
AstaTech | 4-METHYL-2-PYRIDIN-3-YL-THIAZOLE-5-CARBOXYLIC ACID | 5g | 112528156 | 64017 | 97.000 | 39091-01-5 | MFCD00171753 | 220.250 | C10H8N2O2S
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Medchemexpress LLC HY-108324 5mg Medchemexpress, (Z)-Thiothixene CAS:3313-26-6 Purity:>98%
Medchemexpress, HY-108324 5mg (Z)-Thiothixene CAS:3313-26-6 (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-103695 1mg Medchemexpress, CD73-IN-1 CAS:2132396-40-6 Purity:>98%
Medchemexpress, HY-103695 1mg CD73-IN-1 CAS:2132396-40-6 CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Dicyclohexylammonium 3-hydroxy-1-methylpropylmercapturic acid | 33164-70-4 | >95.0% | 416.62 g/mol | C21H40N2O4S | 1 MG
Dicyclohexylammonium 3-hydroxy-1-methylpropylmercapturic acid is a drug metabolite provided as an analytical reference standard for laboratory and analytical research. It is intended for method development, chromatographic assay validation, and metabolite identification workflows.
- Provided as a high-purity analytical standard (>95% by HPLC).
- Suitable for method development and metabolite identification.
- Supplied in small milligram sizes for trace-level analysis.
- Molecular weight 416.62 g/mol and formula C21H40N2O4S for reference.
- Certificate of analysis available with storage and assay details.
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC HY-15734 5mg Medchemexpress, AGI-6780 CAS:1432660-47-3 Purity:>98%
Medchemexpress, HY-15734 5mg AGI-6780 CAS:1432660-47-3 AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2R140Q with IC50 of 23±1.7 nM. AGI-6780 is less potent against IDH2WT with IC50 of 190±8.1 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-15039 5mg Medchemexpress, SSR240612 CAS:464930-42-5 Purity:>98%
Medchemexpress, HY-15039 5mg SSR240612 CAS:464930-42-5 SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC SB 258719 | 195199-95-2 | 338.51 | 50 MG
SB 258719 is a selective 5-HT7 receptor antagonist with a high affinity (pKi=7.5) for the receptor. It can be used for research in cancer and neurological diseases.
- Selective 5-HT7 receptor antagonist
- High affinity for the receptor (pKi=7.5)
- Suitable for research in cancer
- Suitable for research in neurological diseases
Apexbio Technology LLC Glimepiride 93479-97-1 1g
Glimepiride (CAS 93479-97-1) is a sulfonylurea compound widely used in research on type 2 diabetes It primarily acts by enhancing glucose uptake both in the presence and absence of insulin In cultured cells glimepiride (10 M) increases 2-deoxyglucose uptake to 186% of control and upregulates GLUT1 and GLUT4 expression to 164% and 148% of control respectively indicating insulin-independent mechanisms for stimulating cardiac glucose uptake In rodent models glimepiride administration reduced diabetes incidence by 23% in BB rats and decreased blood glucose HbA1c and plasma insulin levels in KK-Ay mice highlighting its utility for investigating glucose metabolism and diabetes pathophysiology
Medchemexpress LLC Glimepiride | 93479-97-1 | 99.9% | C24H34N4O5S | 50 MG
Glimepiride | 93479-97-1 | 99.9% | C24H34N4O5S | 50 MG